Extracellular adenosine-induced Rac1 activation in pulmonary endothelium: Molecular mechanisms and barrier-protective role

Epac1 - a tonic stabilizer of the endothelial barrier

(2016) J. Waschke   Acta Physiologica

Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease

(2016) Frank Lezoualc’h et al.   CIRCULATION RESEARCH

The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages

(2016) José Pablo Vázquez-Medina et al.   FASEB JOURNAL

The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo

(2016) Anita Kovacs-Kasa et al.   Scientific Reports

Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury

(2014) Joyce N. Gonzales et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rap1b in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure

(2014) S. Lakshmikanthan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adenosine Regulates the Proinflammatory Signaling Function of Thrombin in Endothelial Cells

(2014) Seyed Mahdi Hassanian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanisms Regulating Endothelial Permeability

(2014) Sukriti Sukriti et al.   Pulmonary Circulation

Tonic regulation of vascular permeability

(2013) F.-R. E. Curry et al.   Acta Physiologica

Protein phosphatase 2A activity is required for functional adherent junctions in endothelial cells

(2013) Anita Kása et al.   MICROVASCULAR RESEARCH

Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages

(2012) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells

(2012) Yonglin Ren et al.   MICROVASCULAR RESEARCH

FilGAP, a Rho/Rho-associated protein kinase–regulated GTPase-activating protein for Rac, controls tumor cell migration

(2012) Koji Saito et al.   MOLECULAR BIOLOGY OF THE CELL

Prediction of Interaction Between Enzymes and Small Molecules in Metabolic Pathways Through Integrating Multiple Classifiers

(2012) Jin Lu et al.   PROTEIN AND PEPTIDE LETTERS

Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS

(2011) Shampa Chatterjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin  v 3

(2011) S. Lakshmikanthan et al.   BLOOD

Regulation of the inflammatory response of vascular endothelial cells by EPAC1

(2011) Euan Parnell et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular characterization of myosin phosphatase in endothelium

(2011) Kyung-mi Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Control of neurite outgrowth by RhoA inactivation

(2011) Chan-Young Jeon et al.   JOURNAL OF NEUROCHEMISTRY

p190RhoGAP and Rap-dependent RhoGAP (ARAP3) inactivate RhoA in response to nerve growth factor leading to neurite outgrowth from PC12 cells

(2010) Chan-Young Jeon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1

(2010) Robert J. Cain et al.   JOURNAL OF CELL BIOLOGY

Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3

(2010) Chan-Young Jeon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Molecular mechanisms involved in adenosine-induced endothelial cell barrier enhancement

(2010) Nagavedi S. Umapathy et al.   VASCULAR PHARMACOLOGY

Adenosine: An Old Drug Newly Discovered

(2009) Holger K. Eltzschig   ANESTHESIOLOGY

NADPH Oxidases: Functions and Pathologies in the Vasculature

(2009) Bernard Lassègue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

(2009) Maria Grandoch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rac1 GTPase: A “Rac” of All Trades

(2009) E. E. Bosco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability

(2009) Natalia V. Bogatcheva et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown

(2009) Y. Baumer et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of Endothelial Junctional Permeability

(2008) Emily Vandenbroucke et al.   Annals of the New York Academy of Sciences

NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

(2008) Randall S. Frey et al.   ANTIOXIDANTS & REDOX SIGNALING

Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase

(2008) Qian Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Myosin phosphatase target subunit: Many roles in cell function

(2008) Fumio Matsumura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways

(2008) Magdalena J. Lorenowicz et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection

(2007) Anna A. Birukova et al.   JOURNAL OF CELLULAR PHYSIOLOGY