TNF-α-Induced NOD2 and RIP2 Contribute to the Up-Regulation of Cytokines Induced by MDP in Monocytic THP-1 Cells

Both intrinsic and extrinsic apoptotic pathways are involved in Toll-like receptor 4 (TLR4)-induced cell death in monocytic THP-1 cells

(2017) Bei Liu et al.   IMMUNOBIOLOGY

Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells

(2017) Haifang Wang et al.   JOURNAL OF IMMUNOLOGY

A20 Ameliorates Intracerebral Hemorrhage–Induced Inflammatory Injury by Regulating TRAF6 Polyubiquitination

(2016) Zhaoyou Meng et al.   JOURNAL OF IMMUNOLOGY

NOD2 contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and inflammation

(2016) Yu Liu et al.   LIFE SCIENCES

Nod2: A Critical Regulator of Ileal Microbiota and Crohn’s Disease

(2016) Tabasum Sidiq et al.   Frontiers in Immunology

NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation

(2015) Delong Jiao et al.   Cellular & Molecular Immunology

NOD2 is Involved in the Inflammatory Response after Cerebral Ischemia-Reperfusion Injury and Triggers NADPH Oxidase 2-Derived Reactive Oxygen Species

(2015) Huiqing Liu et al.   International Journal of Biological Sciences

Role for NOD2 in Mycobacterium tuberculosis -induced iNOS expression and NO production in human macrophages

(2015) Michelle B. Landes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses in myocardial ischemia/reperfusion injury

(2015) Hongyu Zhang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Z-100, extracted from Mycobacterium tuberculosis strain Aoyama B, promotes TNF-α production via nucleotide-binding oligomerization domain containing 2 (Nod2)-dependent NF-κB activation in RAW264.7 cells

(2015) Kokichi Katsunuma et al.   MOLECULAR IMMUNOLOGY

NOD1 and NOD2 control the invasiveness of trophoblast cells via the MAPK/p38 signaling pathway in human first-trimester pregnancy

(2015) Z. Wang et al.   PLACENTA

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils

(2014) Yu-Jin Jeong et al.   IMMUNOLOGY

NOD2 Stimulation by Staphylococcus aureus-Derived Peptidoglycan Is Boosted by Toll-Like Receptor 2 Costimulation with Lipoproteins in Dendritic Cells

(2014) Holger Schäffler et al.   INFECTION AND IMMUNITY

NOD1 and NOD2 Interact with the Phagosome Cargo in Mast Cells: A Detailed Morphological Evidence

(2014) Giuliano Zabucchi et al.   INFLAMMATION

A Genome-wide Small Interfering RNA (siRNA) Screen Reveals Nuclear Factor-κB (NF-κB)-independent Regulators of NOD2-induced Interleukin-8 (IL-8) Secretion

(2014) Neil Warner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blau Syndrome–AssociatedNod2Mutation Alters Expression of Full-Length NOD2 and Limits Responses to Muramyl Dipeptide in Knock-in Mice

(2014) Jae Dugan et al.   JOURNAL OF IMMUNOLOGY

Protective Effect of Naringenin in Experimental Ischemic Stroke: Down-Regulated NOD2, RIP2, NF-κB, MMP-9 and Up-Regulated Claudin-5 Expression

(2014) Xue Bai et al.   NEUROCHEMICAL RESEARCH

NOD2-Mediated Innate Immune Signaling Regulates the Eicosanoids in Atherosclerosis

(2013) Hui-Qing Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload

(2013) Jing Zong et al.   LABORATORY INVESTIGATION

Nod2 Activates NF-kB in CD4+ T Cells but Its Expression Is Dispensable for T Cell-Induced Colitis

(2013) Galliano Zanello et al.   PLoS One

A20 in inflammation and autoimmunity

(2013) Leen Catrysse et al.   TRENDS IN IMMUNOLOGY

The Interplay between NLRs and Autophagy in Immunity and Inflammation

(2013) Leticia A. M. Carneiro et al.   Frontiers in Immunology

Nod2-Induced Autocrine Interleukin-1 Alters Signaling by ERK and p38 to Differentially Regulate Secretion of Inflammatory Cytokines

(2012) Matija Hedl et al.   GASTROENTEROLOGY

Association between NOD2/CARD15 polymorphisms and coronary artery disease: a case–control study

(2011) Sara Galluzzo et al.   HUMAN IMMUNOLOGY

Toll-like Receptor 3 (TLR3) Induces Apoptosis via Death Receptors and Mitochondria by Up-regulating the Transactivating p63 Isoform α (TAP63α)

(2011) Ruili Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional characterization of the NF-κB binding site in the human NOD2 promoter

(2010) Chaofeng Hu et al.   Cellular & Molecular Immunology

Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen–glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo

(2010) Huiying Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TLR4 Activation Induces Nontolerant Inflammatory Response in Endothelial Cells

(2010) Wenmeng Wang et al.   INFLAMMATION

Nod1 and Nod2 Are Expressed in Human and Murine Renal Tubular Epithelial Cells and Participate in Renal Ischemia Reperfusion Injury

(2010) Alana A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors

(2010) Rebecca C. Coll et al.   Journal of Innate Immunity

Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors

(2010) Terese Petterson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NOD2 polymorphisms predict severe acute graft-versus-host and treatment-related mortality in T-cell-depleted haematopoietic stem cell transplantation

(2009) W J F M van der Velden et al.   BONE MARROW TRANSPLANTATION

The Kinase Activity of Rip2 Determines Its Stability and Consequently Nod1- and Nod2-mediated Immune Responses

(2009) Chiara Nembrini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD2 regulates hematopoietic cell function during graft-versus-host disease

(2009) Olaf Penack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

Caspase-12 Modulates NOD Signaling and Regulates Antimicrobial Peptide Production and Mucosal Immunity

(2008) Philippe M. LeBlanc et al.   Cell Host & Microbe

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

(2008) Osamu Hitotsumatsu et al.   IMMUNITY