Article
Cell Biology
Lin Cheng, Ming-Yuan Zhou, Ying-Jian Gu, Lei Chen, Yun Wang
Summary: ZEB1, an important transcription factor, plays crucial roles in embryonic development, fibrosis, and tumor progression; Abnormal expression of ZEB1 may be associated with poor cancer prognosis; ZEB1 could potentially serve as a biomarker in fibrosis or cancer.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lubna Therachiyil, Roopesh Krishnankutty, Fareed Ahmad, Jericha M. Mateo, Shahab Uddin, Hesham M. Korashy
Summary: This study reveals that activation of aryl hydrocarbon receptor (AhR) affects the progression and metastasis of ovarian cancer, potentially mediated by the activation of the PI3K/Akt, Wnt/β-catenin, and EMT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mehrdokht Sadrkhanloo, Maliheh Entezari, Sima Orouei, Marzieh Ghollasi, Nikoo Fathi, Shamin Rezaei, Elahe Sadat Hejazi, Amirabbas Kakavand, Hamidreza Saebfar, Mehrdad Hashemi, Mohammad Ali Sheikh Beig Goharrizi, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Saeed Samarghandian
Summary: Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for tumor metastasis and inhibition of this process improves prognosis. STAT3 signaling is shown to promote EMT-mediated cancer migration and invasion, and its inhibition suppresses cancer metastasis and improves therapy response.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Oncology
Hongyu Chen, Jianwei Zhang, Lei Yang, Yansen Li, Zhenjun Wang, Chunxiang Ye
Summary: This study found that circ-ZEB1 is significantly upregulated in colorectal cancer tissues. Downregulation of circ-ZEB1 can inhibit the proliferation, migration, and invasion abilities of colorectal cancer cells, as well as attenuate the epithelial-mesenchymal transition and chemoresistance. Mechanistically, circ-ZEB1 can directly bind with miR-200c and function as a sponge to regulate its biological functions in colorectal cancer cells. These findings elucidate circ-ZEB1 as a potential therapeutic target to inhibit the progression of colorectal cancer.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Cell & Tissue Engineering
Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Summary: The study reveals that EIF5A2 positively regulates stemness in ovarian cancer cells through the E2F1/KLF4 pathway, indicating its potential as a target for CSCs-targeted therapy in ovarian cancer.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Marco Giordano, Alessandra Decio, Chiara Battistini, Micol Baronio, Fabrizio Bianchi, Alessandra Villa, Giovanni Bertalot, Stefano Freddi, Michela Lupia, Maria Giovanna Jodice, Paolo Ubezio, Nicoletta Colombo, Raffaella Giavazzi, Ugo Cavallaro
Summary: This study implicates L1CAM in the tumorigenic function of OCSC, showing that L1CAM promotes stemness-related properties in OC cells and tumor initiation. The L1CAM/FGFR1/SRC/STAT3 signaling pathway is identified as a novel driver of OC stemness, providing evidence for potential OC eradication through targeting this pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Correction
Biochemistry & Molecular Biology
Haihai Liang, Tong Yu, Yue Han, Hua Jiang, Chengyu Wang, Tianyi You, Xiaoguang Zhao, Huitong Shan, Rui Yang, Lida Yang, Hongli Shan, Yunyan Gu
Summary: A correction to this paper has been published and is accessible through the original article.
Article
Gastroenterology & Hepatology
Huey-Huey Chua, Mei-Hwei Chang, Ya-Hui Chen, Daw-Jen Tsuei, Yung-Ming Jeng, Po-Huang Lee, Yen-Hsuan Ni
Summary: We identified RBMY as a predictive biomarker for hepatocellular carcinoma metastasis. Provirus integration phosphorylates RBMY, leading to stabilized and translocated RBMY that promotes epithelial-mesenchymal transition and mitochondrial dysregulation in hepatocellular carcinoma, resulting in distant metastasis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Obstetrics & Gynecology
Chencheng Dai, Pengfei Xu, Siyu Liu, Sujuan Xu, Juan Xu, Ziyi Fu, Jian Cao, Mingming Lv, Juan Zhou, Guangquan Liu, Huilin Zhang, Xuemei Jia
Summary: The study revealed that ZEB1-AS1 plays a pivotal role in cancer chemoresistance by regulating MMP19, providing a potential target for overcoming drug resistance in ovarian cancer cells.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Oncology
Rohan R. Katipally, Sean P. Pitroda, Ralph R. Weichselbaum, Samuel Hellman
Summary: The oligometastasis hypothesis suggests that metastases exist on a spectrum and are not always disseminated. Identifying patients most likely to have an oligometastatic phenotype is difficult. Recent research on epigenetic regulators of epithelial-mesenchymal transition (EMT) has shed light on the emergence of a spectrum of metastatic behavior.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Mohammad Aarif Siddiqui, Paradesi Naidu Gollavilli, Vignesh Ramesh, Beatrice Parma, Annemarie Schwab, Maria Eleni Vazakidou, Ramakrishnan Natesan, Ozge Saatci, Ida Rapa, Paolo Bironzo, Harald Schuhwerk, Irfan Ahmed Asangani, Ozgur Sahin, Marco Volante, Paolo Ceppi
Summary: The study identified a functional correlation between thymidylate synthase (TS), EMT, chemotherapy and metastasis in non-small cell lung cancer (NSCLC), establishing TS as a potential therapeutic marker. Further experiments revealed that TS may influence the occurrence and development of NSCLC by regulating EMT transcription factors and effectors.
BRITISH JOURNAL OF CANCER
(2021)
Review
Oncology
Bing Dong, Shiyu Li, Shuangli Zhu, Ming Yi, Suxia Luo, Kongming Wu
Summary: Cancer stem cells (CSCs) play a crucial role in tumorigenesis and cancer progression, with their generation believed to be driven by epithelial-to-mesenchymal transition (EMT). MicroRNAs (miRNAs) have been found to be key players in this process, and regulating miRNAs associated with EMT or CSCs may help overcome drug resistance.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Oncology
Chun-Ying Luo, Wei-Chao Su, Hai-Feng Jiang, Ling-Tao Luo, Dong-Yan Shen, Guo-Qiang Su
Summary: This study reveals the important role of DPY30 in CRC progression and metastasis. DPY30 promotes EMT and CRC metastasis by upregulating the transcriptional expression of ZEB1. Therefore, DPY30 may serve as a therapeutic target and prognostic marker for CRC.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Shuwei Chen, Muwen Yang, Chunyang Wang, Ying Ouyang, Xiangfu Chen, Jiewen Bai, Yameng Hu, Ming Song, Siyi Zhang, Quan Zhang
Summary: The study revealed that FOXD1 is upregulated in oral squamous cell cancer (OSCC) and promotes chemoresistance and epithelial-mesenchymal transition (EMT), with the CYTOR/LPP axis playing a key role in this process. FOXD1 may serve as a potential prognostic marker and therapeutic target for overcoming chemotherapy resistance in OSCC.
Article
Oncology
Ishani H. Rao, Edmund K. Waller, Rohan K. Dhamsania, Sanjay Chandrasekaran
Summary: This study demonstrates a significant association between autocrine VIP secretion and the transcription factor ZEB1 in cancer cells, suggesting a potential role of VIP as a signaling peptide and biomarker of ZEB1-mediated EMT. Gene set analysis further supports the involvement of VIP in EMT and cell cycle pathways. Further studies are necessary to elucidate the specific mechanism of this interaction.
Article
Computer Science, Hardware & Architecture
Sami Salamin, Martin Rapp, Anuj Pathania, Arka Maity, Joerg Henkel, Tulika Mitra, Hussam Amrouch
Summary: The article explores the system- and application-level benefits of NCFET-based multi-/many-core designs compared to state-of-the-art FinFET-based designs in terms of performance and power efficiency. It shows that a novel type of technology-based heterogeneity, in which cores with the same microarchitecture but different ferroelectric (FE) thickness are combined, can significantly increase power efficiency.
IEEE TRANSACTIONS ON COMPUTERS
(2021)
Article
Computer Science, Hardware & Architecture
Zhaoying Li, Dhananjaya Wijerathne, Xianzhang Chen, Anuj Pathania, Tulika Mitra
Summary: This article introduces a CGRA mapper called ChordMap, which automatically generates a high-quality mapping of streaming applications represented as SDF onto CGRAs. By using optimized spatio-temporal mapping and modulo-scheduling, ChordMap achieves higher throughput compared to existing technologies.
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
(2022)
Article
Computer Science, Software Engineering
Guanhua Wang, Sudipta Chattopadhyay, Ivan Gotovchits, Tulika Mitra, Abhik Roychoudhury
Summary: The Spectre vulnerability in modern processors has been widely reported, and the static analysis approach oo7 is proposed to mitigate Spectre attacks by detecting and patching potentially vulnerable code snippets in program binaries. This method can detect various Spectre-vulnerable code patterns, insert fences at vulnerable conditional branches to prevent speculative execution, with an observed performance overhead of around 5.9% on SPECint benchmarks.
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Shreya Bandopadhyay, Parash Prasad, Upasana Ray, Damayanti Das Ghosh, Sib Sankar Roy
Summary: SIRT6 plays a crucial oncogenic role in ovarian cancer by enhancing glycolysis and oxidative phosphorylation in cancer cells, promoting migration and invasion. Its mechanism involves promoting ERK1/2-driven activatory phosphorylation of DRP1 at serine-616, inducing mitochondrial fission and facilitating cell movement important for metastasis. The downregulation of SIRT6 leads to decreased cellular invasion through compromised mitochondrial fragmentation and reduction in stress fiber formation in ovarian cancer cells.
Article
Computer Science, Hardware & Architecture
Dhananjaya Wijerathne, Zhaoying Li, Anuj Pathania, Tulika Mitra, Lothar Thiele
Summary: The article introduces a fast and scalable CGRA mapping method called HiMap, which can generate close-to-optimal solutions, improve performance and energy efficiency, and has a short compilation time.
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
(2022)
Article
Computer Science, Hardware & Architecture
Vanchinathan Venkataramani, Bruno Bodin, Aditi Kulkarni Mohite, Tulika Mitra, Li-Shiuan Peh
Summary: This article proposes an application-specific, non-TDM communication scheduling mechanism for bufferless software-defined NoCs. By utilizing the SDF model and task interactions and timing information, ASCENT achieves high performance and predictability.
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
(2022)
Article
Biochemistry & Molecular Biology
Pritha Mukherjee, Arka Bagchi, Ananya Banerjee, Himansu Roy, Arijit Bhattacharya, Arunima Biswas, Urmi Chatterji
Summary: Ineffective cancer treatment is closely related to the persistence of cancer stem cells (CSCs). The study found that the expression of phosphatidylinositol-3-kinase (PI3K) was upregulated in breast CSCs, while phosphodiesterase 4 (PDE4) levels were higher in breast CSCs compared to normal stem cells. The PDE4 inhibitor rolipram was able to induce cell cycle arrest and apoptosis in CSCs by modulating the PI3K signaling pathway.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Neurosciences
Sutapa Som Chaudhury, Mridula Nandi, Krishna Kumar, Bhuban Ruidas, Tapas Kumar Sur, Parash Prasad, Saikat Chakrabarti, Priyadarsi De, Jaya Sil, Chitrangada Das Mukhopadhyay
Summary: This study investigates the potential therapeutic effects of a novel PEG-based block copolymer on Alzheimer's disease. Results from both animal models and cell lines indicate that the copolymer can alleviate pathological features, behavioral deficits, neuroinflammation, and mitochondrial dysfunction associated with the disease. These findings suggest that the copolymer holds promise for successful clinical trials.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Priyanka Dey Talukdar, Urmi Chatterji
Summary: This review provides an in-depth account of the role and regulation of transcription co-activators, as well as their context-specific contributions in pathophysiological conditions. It also highlights the importance of patient-centered therapeutic strategies and the potential benefits of drugs targeting co-activators in reducing side effects and enhancing efficacy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
Zhaoying Li, Dan Wu, Dhananjaya Wijerathne, Tulika Mitra
Summary: This paper presents a portable compilation framework called LISA, which automatically adjusts to generate high-quality mappings for various spatial accelerators. By using graph neural networks to analyze graph attributes and considering the impact of dataflow graph structure on node placement and dependency routing, an optimized mapping strategy is achieved.
2022 IEEE INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE COMPUTER ARCHITECTURE (HPCA 2022)
(2022)
Proceedings Paper
Automation & Control Systems
Jinho Lee, Burin Amornpaisannon, Tulika Mitra, Trevor E. Carlson
Summary: This research improves the performance and efficiency of graph accelerators by maximizing parallelism and optimizing interconnect structure.
PROCEEDINGS OF THE 2022 DESIGN, AUTOMATION & TEST IN EUROPE CONFERENCE & EXHIBITION (DATE 2022)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Kuluhan Binici, Nam Trung Pham, Tulika Mitra, Karianto Leman
Summary: With the increasing popularity of deep learning on edge devices, compressing large neural networks to meet the hardware requirements of resource-constrained devices has become a significant research direction. This paper addresses the problem of catastrophic forgetting in existing data-free distillation methods and proposes a data-free KD framework that maintains a dynamic collection of generated samples over time. The experiments demonstrate that the proposed framework improves the accuracy of student models obtained via KD on various datasets.
2022 IEEE WINTER CONFERENCE ON APPLICATIONS OF COMPUTER VISION (WACV 2022)
(2022)
Proceedings Paper
Computer Science, Hardware & Architecture
Thilini Kaushalya Bandara, Dhananjaya Wijerathne, Tulika Mitra, Li-Shiuan Peh
Summary: This research aims to improve energy efficiency in CGRAs by introducing heterogeneity and corresponding compiler support. The study proposes an automated design space exploration framework, REVAMP, which converts homogeneous CGRAs into irregular architectures through optimizing compute, network, and memory heterogeneity. The research showcases REVAMP on three homogeneous CGRAs, demonstrating its effectiveness.
ASPLOS '22: PROCEEDINGS OF THE 27TH ACM INTERNATIONAL CONFERENCE ON ARCHITECTURAL SUPPORT FOR PROGRAMMING LANGUAGES AND OPERATING SYSTEMS
(2022)
Article
Computer Science, Hardware & Architecture
Martin Rapp, Anuj Pathania, Tulika Mitra, Joerg Henkel
Summary: The performance of a task on a many-core with distributed shared LLC depends on the power budget and LLC latency. Task migrations can help maintain peak performance. The relative impacts of power budget and LLC latency on task performance may change in different execution phases.
IEEE TRANSACTIONS ON COMPUTERS
(2021)
Article
Toxicology
Zarqua Jamal, Joydeep Das, Payal Gupta, Pubali Dhar, Sreya Chattopadhyay, Urmi Chatterji
Summary: Multiple precedents have confirmed the various illnesses caused by arsenic poisoning, with oxidative stress being the major mechanism by which it inflicts cellular toxicity. Nutraceuticals such as Self Nano-Emulsifying Curcumin play a significant role in combating heavy metal-induced cellular toxicity.
TOXICOLOGY REPORTS
(2021)