Aldehyde dehydrogenase 2 activation ameliorates CCl4 -induced chronic liver fibrosis in mice by up-regulating Nrf2/HO-1 antioxidant pathway

Heme oxygenase 1 protects ethanol-administered liver tissue in  Aldh2 knockout mice

(2016) Akiko Matsumoto et al.   ALCOHOL

Differential Lipotoxic Effects of Palmitate and Oleate in Activated Human Hepatic Stellate Cells and Epithelial Hepatoma Cells

(2016) Alexandra M. Hetherington et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Alda-1 Attenuates Lung Ischemia-Reperfusion Injury by Reducing 4-Hydroxy-2-Nonenal in Alveolar Epithelial Cells

(2016) Jie Ding et al.   CRITICAL CARE MEDICINE

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis

(2016) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis

(2016) Lei He et al.   YONSEI MEDICAL JOURNAL

MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

(2016) Jeongeun Hyun et al.   Nature Communications

Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1β or TNF-α Release from Human Hepatic Stellate Cells

(2016) Sacha Robert et al.   PLoS One

Indigofera oblongifolia Prevents Lead Acetate-Induced Hepatotoxicity, Oxidative Stress, Fibrosis and Apoptosis in Rats

(2016) Ahmed E. Abdel Moneim   PLoS One

Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice

(2015) Jessica A. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic IschemiaSignificance

(2015) Xiangwei Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy

(2015) Rui Guo et al.   JOURNAL OF HEPATOLOGY

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice

(2015) Wei Zhong et al.   JOURNAL OF HEPATOLOGY

Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt/Nrf2/heme oxygenase-1 pathway

(2015) Yung-Hsin Yeh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

(2015) Kaipeng Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeting Pink1-Parkin-mediated mitophagy for treating liver injury

(2015) Jessica A. Williams et al.   PHARMACOLOGICAL RESEARCH

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo

(2015) Che-Hong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway

(2015) Jie-Qiong Ma et al.   Clinics and Research in Hepatology and Gastroenterology

The Role of Autophagy in Liver Diseases: Mechanisms and Potential Therapeutic Targets

(2015) Raffaele Cursio et al.   Biomed Research International

Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis

(2014) Ming-Yi Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

(2014) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice

(2014) Hyo-Jung Kwon et al.   HEPATOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells

(2013) Kaipeng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-fibrotic effect of thymoquinone on hepatic stellate cells

(2013) Mohammed Ghazwani et al.   PHYTOMEDICINE

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

(2012) Patricia Sancho et al.   PLoS One

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

(2010) Heng Ma et al.   EUROPEAN HEART JOURNAL

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alcoholic liver disease

(2009) Robert S. O'Shea et al.   HEPATOLOGY

Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis

(2009) Ying-Hsien Kao et al.   JOURNAL OF HEPATOLOGY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Aldehyde Dehydrogenase 2 in Cardiac Protection: A New Therapeutic Target?

(2009) Grant R. Budas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE

The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

(2007) Ian M. Copple et al.   TOXICOLOGY