Deoxycholic acid activates epidermal growth factor receptor and promotes intestinal carcinogenesis by ADAM17-dependent ligand release

Secondary bile acid-induced dysbiosis promotes intestinal carcinogenesis

(2017) Hailong Cao et al.   INTERNATIONAL JOURNAL OF CANCER

ADAM Proteases and Gastrointestinal Function

(2016) Jennifer C. Jones et al.   Annual Review of Physiology

Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells

(2016) Sara M. Centuori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model

(2016) Chenbo Ding et al.   BMC CANCER

Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+mouse model

(2016) Sayeh Savari et al.   CARCINOGENESIS

Gastrointestinal Microbiota and Colon Cancer

(2016) Georgina L. Hold   DIGESTIVE DISEASES

Overcoming resistance to anti-EGFR therapy — where do we stand?

(2016) Marta Schirripa et al.   Nature Reviews Gastroenterology & Hepatology

Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model

(2016) Tara Williamson et al.   Oncotarget

Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF- : Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

(2014) N. S. Nagathihalli et al.   CANCER RESEARCH

The secondary bile acid, deoxycholate accelerates intestinal adenoma–adenocarcinoma sequence in Apc min/+ mice through enhancing Wnt signaling

(2014) Hailong Cao et al.   Familial Cancer

ADAM17 at the interface between inflammation and autoimmunity

(2014) Sabrina Lisi et al.   IMMUNOLOGY LETTERS

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Activation of Epidermal Growth Factor Receptor Mediates Mucin Production Stimulated by p40, aLactobacillus rhamnosusGG-derived Protein

(2014) Lihong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

(2014) Manon D. Schulz et al.   NATURE

Bile acids are nutrient signaling hormones

(2014) Huiping Zhou et al.   STEROIDS

Secondary bile acids: an underrecognized cause of colon cancer

(2014) Hana Ajouz et al.   World Journal of Surgical Oncology

Chemopreventive effects of berberine on intestinal tumor development in Apc min/+mice

(2013) Hailong Cao et al.   BMC GASTROENTEROLOGY

ALactobacillus rhamnosusGG-derived Soluble Protein, p40, Stimulates Ligand Release from Intestinal Epithelial Cells to Transactivate Epidermal Growth Factor Receptor

(2013) Fang Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

(2013) Junfang Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ADAM17, shedding, TACE as therapeutic targets

(2013) Stefan Rose-John   PHARMACOLOGICAL RESEARCH

Berberine Inhibits Proliferation and Down-Regulates Epidermal Growth Factor Receptor through Activation of Cbl in Colon Tumor Cells

(2013) Lihong Wang et al.   PLoS One

Suppression of the Epidermal Growth Factor Receptor Inhibits Epithelial–Mesenchymal Transition in Human Pancreatic Cancer PANC-1 Cells

(2012) Zhi-Gang Chang et al.   DIGESTIVE DISEASES AND SCIENCES

Carcinogenicity of deoxycholate, a secondary bile acid

(2011) Carol Bernstein et al.   ARCHIVES OF TOXICOLOGY

EGFR-targeted therapy

(2011) Loredana Vecchione et al.   EXPERIMENTAL CELL RESEARCH

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer

(2010) Alberto Bardelli et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells

(2010) Y Gan et al.   ONCOGENE

Bile acids: short and long term effects in the intestine

(2010) Antal Bajor et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Saccharomyces boulardii Inhibits EGF Receptor Signaling and Intestinal Tumor Growth in Apcmin Mice

(2009) Xinhua Chen et al.   GASTROENTEROLOGY

Bile acids as endogenous etiologic agents in gastrointestinal cancer

(2009) Harris Bernstein et al.   WORLD JOURNAL OF GASTROENTEROLOGY

TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer

(2008) N. B. Merchant et al.   CLINICAL CANCER RESEARCH