SV40 intron, a potent strong intron element that effectively increases transgene expression in transfected Chinese hamster ovary cells

The EF-1α promoter maintains high-level transgene expression from episomal vectors in transfected CHO-K1 cells

(2017) Xiaoyin Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Impact of different promoters, promoter mutation, and an enhancer on recombinant protein expression in CHO cells

(2017) Wen Wang et al.   Scientific Reports

Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

(2017) Chun-Peng Zhao et al.   Scientific Reports

A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells

(2016) Shin-Young Kang et al.   Biotechnology Journal

High levels of histone H3 acetylation at the CMV promoter are predictive of stable expression in Chinese hamster ovary cells

(2016) Benjamin Moritz et al.   BIOTECHNOLOGY PROGRESS

The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells

(2016) Masatsugu Masuda et al.   MOLECULAR NEUROBIOLOGY

A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells

(2016) Shin-Young Kang et al.   Biotechnology Journal

Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells

(2015) Niamh Harraghy et al.   Biotechnology Journal

MAR characteristic motifs mediate episomal vector in CHO cells

(2015) Yan Lin et al.   GENE

Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells

(2015) Niamh Harraghy et al.   Biotechnology Journal

Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

(2015) Fay Saunders et al.   PLoS One

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

(2013) Helene Faustrup Kildegaard et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genomic cis-acting Sequences Improve Expression and Establishment of a Nonviral Vector

(2013) Claudia Hagedorn et al.   Molecular Therapy-Nucleic Acids

A minimal cytomegalovirus intron A variant can improve transgene expression in different mammalian cell lines

(2012) L. S. Quilici et al.   BIOTECHNOLOGY LETTERS

Different matrix attachment regions flanking a transgene effectively enhance gene expression in stably transfected Chinese hamster ovary cells

(2012) Fang Wang et al.   GENE

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Methods to create a stringent selection system for mammalian cell lines

(2011) H. J. M. Van Blokland et al.   CYTOTECHNOLOGY

Identification of a potent MAR element from the mouse genome and assessment of its activity in stable and transient transfections

(2011) Niamh Harraghy et al.   JOURNAL OF BIOTECHNOLOGY

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Evaluating regulatory elements of human cytomegalovirus major immediate early gene for enhancing transgene expression levels in CHO K1 and HEK293 cells

(2010) Mariati et al.   JOURNAL OF BIOTECHNOLOGY

A systematic study of the function of the human β-globin introns on the expression of the human coagulation factor IX in cultured Chinese hamster ovary cells

(2009) Aliakbar Haddad-Mashadrizeh et al.   JOURNAL OF GENE MEDICINE

Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells

(2009) Mariati et al.   PROTEIN EXPRESSION AND PURIFICATION

Enhanced expression of transgene in CHO cells using matrix attachment region

(2008) T WANG et al.   CELL BIOLOGY INTERNATIONAL

Production of Recombinant Human Factor VIII in Different Cell Lines and the Effect of Human XBP1 Co-Expression

(2008) Mariana Campos-da-Paz et al.   MOLECULAR BIOTECHNOLOGY