Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK-ERK signalling pathway in vivo and in vitro

Inflammation in intervertebral disc degeneration and regeneration

(2015) Mário Molinos et al.   Journal of the Royal Society Interface

The role of leptin in regulating bone metabolism

(2015) Jagriti Upadhyay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation of energy metabolism by the skeleton: Osteocalcin and beyond

(2014) Mathieu Ferron et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-ĸB signaling pathways in human chondrocytes

(2014) Kursat Oguz Yaykasli et al.   CELL BIOLOGY INTERNATIONAL

Leptin - A Link between Obesity and Osteoarthritis. Applications for Prevention and Treatment

(2013) Katriina Vuolteenaho et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: New implications for osteonecrosis treatment?

(2013) Chang She et al.   CELLULAR SIGNALLING

Leptin in Joint and Bone Diseases: New Insights

(2013) M. Scotece et al.   CURRENT MEDICINAL CHEMISTRY

Long-term Etanercept Therapy Favors Weight Gain and Ameliorates Cachexia in Rheumatoid Arthritis Patients: Roles of Gut Hormones and Leptin

(2013) Chih-Yen Chen et al.   CURRENT PHARMACEUTICAL DESIGN

Adipokines as drug targets in joint and bone disease

(2013) Morena Scotece et al.   DRUG DISCOVERY TODAY

Leptin Promotes the Osteoblastic Differentiation of Vascular Smooth Muscle Cells From Female Mice by Increasing RANKL Expression

(2013) Guan-Ying Liu et al.   ENDOCRINOLOGY

Inflammation and Hypertension in Rheumatoid Arthritis

(2013) S. Manavathongchai et al.   JOURNAL OF RHEUMATOLOGY

Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways

(2012) Ronaldo J. Chavez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Serum Leptin, Parathyroid Hormone, 1,25-Dihydroxyvitamin D, Fibroblast Growth Factor 23, Bone Alkaline Phosphatase, and Sclerostin Relationships in Obesity

(2012) Elizabeth Grethen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Oxidative Damage, Platelet Activation, and Inflammation to Predict Mobility Disability and Mortality in Older Persons: Results From the Health Aging and Body Composition Study

(2012) M. Cesari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ghrelin Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells through the ERK Pathway

(2012) Qiu-Hua Liang et al.   PLoS One

The Relationship Between Concave Angle of Vertebral Endplate and Lumbar Intervertebral Disc Degeneration

(2012) Xian He et al.   SPINE

ISSLS Prize Winner

(2012) Yue Wang et al.   SPINE

Leptin in human physiology and pathophysiology

(2011) Christos S. Mantzoros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

(2011) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

(2011) G. Livshits et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Leptin and cardiovascular diseases

(2011) Ning Hou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus

(2011) Niki Katsiki et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Leptin regulates estrogen receptor gene expression in ATDC5 cells through the extracellular signal regulated kinase signaling pathway

(2011) Shan-Jin Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Change in abdominal obesity and risk of coronary calcification

(2011) S. Sabour et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Apelin Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells

(2011) Peng-Fei Shan et al.   PLoS One

The osseous endplates in lumbar vertebrae: Thickness, bone mineral density and their associations with age and disk degeneration

(2010) Yue Wang et al.   BONE

Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α,25-dihydroxyvitamin D3 synthesis in leptin-deficient ob/ob Mice

(2010) Kiyomi Tsuji et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypothalamic regulation of bone

(2010) Frank Driessler et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes

(2010) S. Ohba et al.   OSTEOARTHRITIS AND CARTILAGE

Vascularization and Morphological Changes of the Endplate After Axial Compression and Distraction of the Intervertebral Disc

(2010) Hwan Tak Hee et al.   SPINE

The relationship between disc degeneration, low back pain, and human pain genetics

(2010) Kenneth M.C. Cheung   Spine Journal

RANKL Increases Vascular Smooth Muscle Cell Calcification Through a RANK-BMP4–Dependent Pathway

(2009) Sara Panizo et al.   CIRCULATION RESEARCH

Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis

(2009) Jung Hoei Ku et al.   CLINICAL RHEUMATOLOGY

Leptin increases growth of primary ossification centers in fetal mice

(2009) Laura Bertoni et al.   JOURNAL OF ANATOMY

Impact of Chronic Musculoskeletal Pathology on Older Adults: A Study of Differences between Knee OA and Low Back Pain

(2009) Natalia E. Morone et al.   PAIN MEDICINE

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL