Leptin - A Link between Obesity and Osteoarthritis. Applications for Prevention and Treatment

Restricted leptin antagonism as a therapeutic approach to treatment of autoimmune diseases

(2014) Arash Babaei et al.   Hormones-International Journal of Endocrinology and Metabolism

Adipokines as drug targets in joint and bone disease

(2013) Morena Scotece et al.   DRUG DISCOVERY TODAY

Leptin levels are increased and its negative regulators, SOCS-3 and sOb-R are decreased in obese patients with osteoarthritis: a link between obesity and osteoarthritis: Figure 1

(2012) Katriina Vuolteenaho et al.   ANNALS OF THE RHEUMATIC DISEASES

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Adiponectin and Leptin Induce VCAM-1 Expression in Human and Murine Chondrocytes

(2012) Javier Conde et al.   PLoS One

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

(2011) I. R. Klein-Wieringa et al.   ANNALS OF THE RHEUMATIC DISEASES

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

(2011) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Body mass index and susceptibility to knee osteoarthritis: A systematic review and meta-analysis

(2011) Liying Jiang et al.   JOINT BONE SPINE

What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies

(2011) Stella G. Muthuri et al.   ARTHRITIS CARE & RESEARCH

Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis

(2010) P. Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

The relationship between body mass index and hip osteoarthritis: A systematic review and meta-analysis

(2010) Liying Jiang et al.   JOINT BONE SPINE

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

(2010) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

(2010) O. Stannus et al.   OSTEOARTHRITIS AND CARTILAGE

Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis

(2010) Stéphane Pallu et al.   ARTHRITIS RESEARCH & THERAPY

Association between weight or body mass index and hand osteoarthritis: a systematic review

(2009) E. Yusuf et al.   ANNALS OF THE RHEUMATIC DISEASES

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis

(2009) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

The infrapatellar fat pad in knee osteoarthritis: An important source of interleukin-6 and its soluble receptor

(2009) Emilie Distel et al.   ARTHRITIS AND RHEUMATISM

Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis

(2009) Jung Hoei Ku et al.   CLINICAL RHEUMATOLOGY

Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-InducedPGE2, IL-6, and IL-8 Production

(2009) Katriina Vuolteenaho et al.   MEDIATORS OF INFLAMMATION

Leptin plays a catabolic role on articular cartilage

(2009) Jia-peng Bao et al.   MOLECULAR BIOLOGY REPORTS

Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study

(2009) Yuanyuan Wang et al.   ARTHRITIS RESEARCH & THERAPY

Circulating Levels of Inflammatory Markers Predict Change in Bone Mineral Density and Resorption in Older Adults: A Longitudinal Study

(2008) Changhai Ding et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM