Overexpression of PP1–NIPP1 limits the capacity of cells to repair DNA double-strand breaks

MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation

(2017) Hailong Liu et al.   MOLECULAR CANCER RESEARCH

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

(2017) Beatrice Rondinelli et al.   NATURE CELL BIOLOGY

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export

(2017) Jekaterina Vohhodina et al.   NUCLEIC ACIDS RESEARCH

Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining

(2017) Songli Zhu et al.   NUCLEIC ACIDS RESEARCH

The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis

(2017) Mónica Ferreira et al.   Scientific Reports

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

(2017) Robert C. Alver et al.   Cell Reports

The DNA fibre technique – tracking helicases at work

(2016) Jadwiga Nieminuszczy et al.   METHODS

Brief Report: The Deletion of the Phosphatase Regulator NIPP1 Causes Progenitor Cell Expansion in the Adult Liver

(2016) Shannah Boens et al.   STEM CELLS

Targeting DNA Replication Stress for Cancer Therapy

(2016) Jun Zhang et al.   Genes

The Yin and Yang of R-loop biology

(2015) Lorenzo Costantino et al.   CURRENT OPINION IN CELL BIOLOGY

The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth

(2015) C. Winkler et al.   JOURNAL OF CELL SCIENCE

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits

(2015) Toon Verheyen et al.   NUCLEIC ACIDS RESEARCH

Beyond Glycolysis: GAPDHs Are Multi-functional Enzymes Involved in Regulation of ROS, Autophagy, and Plant Immune Responses

(2015) Elizabeth Henry et al.   PLoS Genetics

Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events

(2014) Rachael A McCloy et al.   CELL CYCLE

Double strand break (DSB) repair in heterochromatin and heterochromatin proteins in DSB repair

(2014) Charlène Lemaître et al.   DNA REPAIR

Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion

(2014) S. Sundaramoorthy et al.   EMBO JOURNAL

Making an impact:FEBS Open Biocelebrates its 3rd anniversary

(2014) Mary Purton   FEBS LETTERS

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

(2014) K. Skourti-Stathaki et al.   GENES & DEVELOPMENT

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

(2014) Kienan I. Savage et al.   MOLECULAR CELL

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

A Selected Core Microbiome Drives the Early Stages of Three Popular Italian Cheese Manufactures

(2014) Francesca De Filippis et al.   PLoS One

Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe

(2014) R Mu et al.   Cell Death & Disease

R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome

(2014) Matthias Groh et al.   PLoS Genetics

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Response to DNA damage: why do we need to focus on protein phosphatases?

(2013) Midori Shimada et al.   Frontiers in Oncology

The PP1 binding code: a molecular-lego strategy that governs specificity

(2012) Ewald Heroes et al.   FEBS Journal

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes

(2012) Nikki Minnebo et al.   NUCLEIC ACIDS RESEARCH

The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme

(2012) Nichole O'Connell et al.   STRUCTURE

Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique

(2011) Rebekka A.V. Schwab et al.   Jove-Journal of Visualized Experiments

The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response

(2010) Helga B Landsverk et al.   EMBO REPORTS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets

(2010) Nele Van Dessel et al.   NUCLEIC ACIDS RESEARCH

Serine/threonine phosphatases in the DNA damage response and cancer

(2010) A Peng et al.   ONCOGENE

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint

(2009) Nianxiang Zhang et al.   EMBO REPORTS

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

Native R-loops Persist throughout the Mouse Mitochondrial DNA Genome

(2008) Timothy A. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Inhibitor of Protein Phosphatase-1 (NIPP1) Directs Protein Phosphatase-1 (PP1) to Dephosphorylate the U2 Small Nuclear Ribonucleoprotein Particle (snRNP) Component, Spliceosome-associated Protein 155 (Sap155)

(2008) Nobuhiro Tanuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY