Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43

Desmoplakin missense and non-missense mutations in arrhythmogenic right ventricular cardiomyopathy: Genotype-phenotype correlation

(2017) Silvia Castelletti et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Desmosomal junctions are necessary for adult sinus node function

(2016) Valeria Mezzano et al.   CARDIOVASCULAR RESEARCH

Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin GeneNovelty and Significance

(2016) Raffaella Lombardi et al.   CIRCULATION RESEARCH

Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes

(2016) Adi D. Dubash et al.   JOURNAL OF CELL BIOLOGY

RAS isoforms and mutations in cancer at a glance

(2016) G. Aaron Hobbs et al.   JOURNAL OF CELL SCIENCE

Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing

(2016) Vera Rötzer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Gap junctions–guards of excitability

(2015) Line Waring Stroemlund et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dominantde novo DSPmutations cause erythrokeratodermia-cardiomyopathy syndrome

(2015) Lynn M. Boyden et al.   HUMAN MOLECULAR GENETICS

Two Novel Homozygous Desmoplakin Mutations in Carvajal Syndrome

(2015) Vered Molho-Pessach et al.   PEDIATRIC DERMATOLOGY

Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain

(2015) Irena Antic et al.   Nature Communications

MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma

(2015) Lin Wang et al.   Oncotarget

Desmosomes in the Heart: A Review of Clinical and Mechanistic Analyses

(2014) Dipal M. Patel et al.   CELL COMMUNICATION AND ADHESION

Remodeling of Cell-Cell Junctions in Arrhythmogenic Cardiomyopathy

(2014) Angeliki Asimaki et al.   CELL COMMUNICATION AND ADHESION

Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B and glioblastoma

(2014) Y Zhang et al.   CELL DEATH AND DIFFERENTIATION

Desmoplakin truncations and arrhythmogenic left ventricular cardiomyopathy: characterizing a phenotype

(2014) Jose María López-Ayala et al.   EUROPACE

Specific Cx43 phosphorylation events regulate gap junction turnover in vivo

(2014) Joell L. Solan et al.   FEBS LETTERS

EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368

(2014) John T. Fong et al.   FEBS LETTERS

Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin–EB1 interactions

(2014) Dipal M. Patel et al.   JOURNAL OF CELL BIOLOGY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Missense Mutations in Plakophilin-2 Cause Sodium Current Deficit and Associate With a Brugada Syndrome Phenotype

(2013) Marina Cerrone et al.   CIRCULATION

Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model

(2013) Robert C. Lyon et al.   HUMAN MOLECULAR GENETICS

Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation

(2013) A. Wolf et al.   JOURNAL OF CELL SCIENCE

Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells

(2013) Kristen E. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Managing the complexity of communication: regulation of gap junctions by post-translational modification

(2013) Lene N. Axelsen et al.   Frontiers in Pharmacology

Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/β-catenin signaling pathway in human lung cancer

(2012) Linlin Yang et al.   CARCINOGENESIS

Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency

(2012) Marina Cerrone et al.   CARDIOVASCULAR RESEARCH

Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study

(2012) John Gomes et al.   EUROPEAN HEART JOURNAL

The DSPII splice variant is crucial for desmosome-mediated adhesion in HaCaT keratinocytes

(2012) Rita M. Cabral et al.   JOURNAL OF CELL SCIENCE

Association of Connexin43 with E3 Ubiquitin Ligase TRIM21 Reveals a Mechanism for Gap Junction Phosphodegron Control

(2012) Vincent C. Chen et al.   JOURNAL OF PROTEOME RESEARCH

Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues

(2011) Lucrecia Márquez-Rosado et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Altered Desmosomal Proteins in Granulomatous Myocarditis and Potential Pathogenic Links to Arrhythmogenic Right Ventricular Cardiomyopathy

(2011) Angeliki Asimaki et al.   Circulation-Arrhythmia and Electrophysiology

Inhibition of Ras for cancer treatment: the search continues

(2011) Antonio T Baines et al.   Future Medicinal Chemistry

Gap junctions and arrhythmogenic cardiomyopathy

(2011) Angeliki Asimaki et al.   HEART RHYTHM

Arrhythmogenic Cardiomyopathy: Etiology, Diagnosis, and Treatment

(2010) Srijita Sen-Chowdhry et al.   Annual Review of Medicine

miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras

(2010) Ki-Hyuk Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Tumor-Suppressive Function of Connexin43 in Keratinocytes Is Mediated in Part via Interaction with Caveolin-1

(2010) S. Langlois et al.   CANCER RESEARCH

Arrhythmogenic right ventricular cardiomyopathy: new insights into mechanisms of disease

(2010) Jeffrey E. Saffitz et al.   CARDIOVASCULAR PATHOLOGY

Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia

(2010) Maria E. Campian et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Plakophilin 2 Couples Actomyosin Remodeling to Desmosomal Plaque Assembly via RhoA

(2010) Lisa M. Godsel et al.   MOLECULAR BIOLOGY OF THE CELL

Plakophilins: multifunctional scaffolds for adhesion and signaling

(2009) Amanda E Bass-Zubek et al.   CURRENT OPINION IN CELL BIOLOGY

Cardiac hypertrophy: Targeting Raf/MEK/ERK1/2-signaling

(2009) Kristina Lorenz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Arrhythmogenic right ventricular cardiomyopathy

(2009) Cristina Basso et al.   LANCET

A New Diagnostic Test for Arrhythmogenic Right Ventricular Cardiomyopathy

(2009) Angeliki Asimaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gap Junctions

(2009) D. A. Goodenough et al.   Cold Spring Harbor Perspectives in Biology

Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption

(2008) R. P. Norris et al.   DEVELOPMENT

The area composita of adhering junctions connecting heart muscle cells of vertebrates. V. The importance of plakophilin-2 demonstrated by small interference RNA-mediated knockdown in cultured rat cardiomyocytes

(2008) Sebastian Pieperhoff et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Plakophilin 2: a critical scaffold for PKCα that regulates intercellular junction assembly

(2008) Amanda E. Bass-Zubek et al.   JOURNAL OF CELL BIOLOGY