Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ

Kindlin-2 Association with Rho GDP-Dissociation InhibitorαSuppresses Rac1 Activation and Podocyte Injury

(2017) Ying Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Structural basis of kindlin-mediated integrin recognition and activation

(2017) Huadong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

(2016) Q Chen et al.   CELL DEATH AND DIFFERENTIATION

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Kindlin-2 directly binds actin and regulates integrin outside-in signaling

(2016) Kamila Bledzka et al.   JOURNAL OF CELL BIOLOGY

Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis

(2016) Huan Jing et al.   MOLECULAR THERAPY

The Hippo pathway in intestinal regeneration and disease

(2016) Audrey W. Hong et al.   Nature Reviews Gastroenterology & Hepatology

RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix

(2016) Changjun Li et al.   Nature Communications

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

Excess Integrins Cause Lung Entrapment of Mesenchymal Stem Cells

(2015) Shan Wang et al.   STEM CELLS

Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells

(2015) Alexandra Karystinou et al.   ARTHRITIS RESEARCH & THERAPY

Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis

(2015) Chuanyue Wu et al.   Nature Communications

Mechanism of regulation of stem cell differentiation by matrix stiffness

(2015) Hongwei Lv et al.   Stem Cell Research & Therapy

Kindlin-2 Tyrosine Phosphorylation and Interaction with Src Serve as a Regulatable Switch in the Integrin Outside-in Signaling Circuit

(2014) Hong Qu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic changes of mesenchymal stem cells in three-dimensional (3D) spheroids

(2014) Ling Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Role of extracellular matrix and YAP/TAZ in cell fate determination

(2013) Jin Hao et al.   CELLULAR SIGNALLING

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Mesenchymal Stem Cell and Chondrocyte Fates in a Multishear Microdevice Are Regulated by Yes-Associated Protein

(2013) Weiliang Zhong et al.   STEM CELLS AND DEVELOPMENT

Stem cell regulation by the Hippo pathway

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Increased Marrow Adiposity in Premenopausal Women with Idiopathic Osteoporosis

(2012) Adi Cohen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins

(2011) H. Qu et al.   JOURNAL OF CELL SCIENCE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Epigenetic Dysregulation in Mesenchymal Stem Cell Aging and Spontaneous Differentiation

(2011) Zhilong Li et al.   PLoS One

Effects of obesity on bone metabolism

(2011) Jay J Cao   Journal of Orthopaedic Surgery and Research

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Vertebral Bone Marrow Fat Is Positively Associated With Visceral Fat and Inversely Associated With IGF-1 in Obese Women

(2010) Miriam A. Bredella et al.   Obesity

Cytoskeletal control of growth and cell fate switching

(2009) Akiko Mammoto et al.   CURRENT OPINION IN CELL BIOLOGY

Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors

(2009) Kazuhiro Aoki et al.   Nature Protocols

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the Drosophila Hippo Pathway

(2008) J. Zhang et al.   CANCER RESEARCH

Kindlin-2 Is an Essential Component of Intercalated Discs and Is Required for Vertebrate Cardiac Structure and Function

(2008) James J. Dowling et al.   CIRCULATION RESEARCH

Kindlins: essential regulators of integrin signalling and cell–matrix adhesion

(2008) Hannu Larjava et al.   EMBO REPORTS

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

Regulatory divergence modifies limb length between mammals

(2008) C. J. Cretekos et al.   GENES & DEVELOPMENT

Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)

(2008) Tsutomu Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY