Article
Food Science & Technology
Qi Zhang, Sijing Hu, Jianjun Wu, Peng Sun, Quanlong Zhang, Yang Wang, Qiming Zhao, Ting Han, Luping Qin, Qiaoyan Zhang
Summary: The oligosaccharide NST derived from Morinda officinalis demonstrated potential in preventing bone loss and promoting osteogenic differentiation of BMSCs, providing a potential alternative medicine for the treatment of osteoporosis.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Cell & Tissue Engineering
Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang
Summary: The loss of NFIX gene affects endochondral ossification and mineralization in bone, with NFIX inducing osteoblast differentiation and impairing adipocyte formation by regulating HMGA1 expression. HMGA1 plays a role in osteoblast commitment and mediates NFIX function by activating canonical Wnt signaling pathways.
Article
Chemistry, Multidisciplinary
Jing Ge, Ye-jia Yu, Jia-yi Li, Meng-yu Li, Si-mo Xia, Ke Xue, Shao-yi Wang, Chi Yang
Summary: The soy isoflavone genistein can promote osteoblast differentiation of bone marrow mesenchymal stem cells (MSCs) by activating autophagy and the Wnt/β-catenin signaling pathway. This finding provides insights into the role of autophagy in the treatment of postmenopausal osteoporosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell & Tissue Engineering
Xiaoli Shi, Yunzhu Cen, Liying Shan, Lijie Tian, Endong Zhu, Hairui Yuan, Xiaoxia Li, Ying Liu, Baoli Wang
Summary: The study revealed that NDRG1 negatively regulated cell growth and modulated the differentiation of marrow stromal progenitor cells towards adipocytes, impacting the osteoblast differentiation. NDRG1 interacted with LRP6 and inactivated the canonical Wnt/beta-catenin signaling cascade in stromal progenitor cells. In vivo transfection of Ndrg1 siRNA prevented inactivation of Wnt signaling and improved osteoblasts reduction and fat accumulation in ovariectomized mice.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Jilly Frances Evans, Kseniya Obraztsova, Susan M. Lin, Vera P. Krymskaya
Summary: The study focuses on the mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks and their impact on cancer, drug resistance, and stem cell exhaustion, as well as the lung disease lymphangioleiomyomatosis (LAM). The review highlights potential therapeutic approaches targeting these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yongkun Wei, Huiling Ma, Haiqing Zhou, Hanrong Yin, Jie Yang, Yongcai Song, Binhui Yang
Summary: Research indicates that overexpression of miR-424-5p in BMSCs-derived exosomes can regulate osteogenic differentiation of osteoblasts through the WIF1/Wnt/beta-catenin pathway, suggesting miR-424-5p as a potential new biomarker for the treatment of osteoporosis.
Article
Environmental Sciences
Ahmed G. Abd Elhameed, Manar G. Helal, Eman Said, Hatem A. Salem
Summary: The study demonstrated that saxagliptin can delay experimentally-induced hepatocellular carcinoma progression by improving liver function biomarkers and acting through the suppression of specific signaling pathways, enhancing tumor apoptosis, and suppressing proliferation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Cell Biology
Yi Wang, Ying Gan, Yuan Dong, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Tax1bp3 is a PDZ domain-containing protein that is overexpressed in cancer and can regulate the differentiation of mesenchymal progenitor cells into osteoblasts and adipocytes. It inhibits osteogenic differentiation and promotes adipogenic differentiation by inhibiting the activation of Wnt/beta-catenin and BMPs/Smads signaling pathways.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Meng Chen, Liying Shan, Ying Gan, Lijie Tian, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: MTSS1 plays a role in osteoblast differentiation and bone homeostasis by regulating Src-Wnt/beta-catenin signaling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yunok Oh, Chang-Bum Ahn, M. P. C. K. Marasinghe, Jae-Young Je
Summary: Chitosan, a naturally occurring biodegradable polymer, demonstrates osteogenic effects in murine bone marrow-derived mesenchymal stem cells. Grating gallic acid onto chitosan enhances its potential for osteogenesis. Mechanistic study shows that GAC activates the Wnt signaling pathway to promote osteoblast differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Endocrinology & Metabolism
Ji Yeon Lee, Jae-Yeon Yang, Sang Wan Kim
Summary: Lineage-tracing studies have shown that parathyroid hormone and anti-sclerostin antibody can convert bone lining cells into active osteoblasts, while these cells may also differentiate into bone marrow adipocytes. Rosiglitazone can stimulate this differentiation process, but Scl-Ab administration may suppress it, contributing to anabolic effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
San-Zhong Liu, Kai-Xi Ren, Jing Zhao, Shuang Wu, Juan Li, Jian Zang, Zhou Fei, Jun-Long Zhao
Summary: The study revealed that miR-139 and its host gene PDE2A have anti-tumor effects in glioblastomas by regulating GSC stemness. PDE2A and miR-139 modulate GSC characteristics through the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yang Zheng, Panyang Shen, Mengsha Tong, Hangchao Li, Conglin Ren, Fengqing Wu, Hanyu Li, Huan Yang, Bingbing Cai, Weibin Du, Xing Zhao, Shasha Yao, Renfu Quan
Summary: This study reveals the important role of bone marrow mesenchymal stem cells (BMSCs) in congenital scoliosis (CS). CS-BMSCs showed decreased osteogenic differentiation ability compared to BMSCs from healthy donors. The downregulation of WISP2 was associated with the impaired osteogenic differentiation of CS-BMSCs, and overexpression of WISP2 can promote osteogenesis in CS-BMSCs via the Wnt/beta-catenin pathway. These findings provide new insights into the pathogenesis of CS.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Medicine, Research & Experimental
Anirban Sardar, Shalini Gautam, Shradha Sinha, Divya Rai, Ashish Kumar Tripathi, Geeta Dhaniya, Prabhat Ranjan Mishra, Ritu Trivedi
Summary: In this study, nanoparticles of betulinic acid (BA/NPs) were synthesized and tested in altered bone metabolisms developed after ovariectomy. The results showed that BA/NPs exert potential osteogenic efficacy by modulating key osteogenic markers and the Wnt/β-catenin signaling pathway, and can reduce bone marrow adiposity and pathological bone loss.
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: MSCs are a heterogeneous cell population found in various tissues in the body, with important regulatory functions, especially in the bone marrow where they play a critical role in regulating HSCs. They contribute to maintaining bone integrity and hormonal nutrition supply, as well as regulating the homeostasis and differentiation of the HSC niche through differentiation into different cell types. Research on MSCs helps understand their role in regulating cell interactions and homeostasis in the body.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Xin Luan, Hebao Yuan, Yudong Song, Hongxiang Hu, Bo Wen, Miao He, Huixia Zhang, Yan Li, Feng Li, Pan Shu, Joseph P. Burnett, Nathan Truchan, Maria Palmisano, Manjunath P. Pai, Simon Zhou, Wei Gao, Duxin Sun
Summary: The study investigates the design criteria of nanomedicines in different preclinical cancer models, revealing factors for better clinical translations of efficacy/safety. Short-circulating nanomedicines show potential advantages over long-circulating nanomedicines in certain aspects.
Article
Biophysics
Renata Gilfanova, Andrea Callegari, Adam Childs, Gaomai Yang, Miranda Luarca, Alan G. Gutierrez, Karla I. Medina, Justin Mai, Alvin Hui, Mark Kline, Xiaoxi Wei, Philip J. Norris, Marcus O. Muench
Summary: Novel ice-interactive cryoprotectants, inspired by natural antifreeze proteins, have shown promising results as substitutes for DMSO-based media in the cryopreservation of hematopoietic stem cells. Through extreme limiting dilution analysis and bone marrow engraftment measurements, the effectiveness of these cryoprotectants in terms of stem cell frequency and recovery numbers have been confirmed.
BONE MARROW TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Yuan-Lynn Hsieh, Xiaoxi Wei, Yating Wang, Honghao Zhang, Shuqun Qi, Di Xie, Yuji Mishina, Daniela Mendonca, Nan Hatch, Fei Liu
Summary: This study revealed that Tsc1 deletion in chondrocytes leads to abnormal skull development via constitutive activation of mTORC1 signaling. Mutant mice showed expanded cranial base synchondroses with increased cell number and size. Treatment with rapamycin rescued the abnormalities in synchondroses, highlighting the importance of TSC1-mTORC1 signaling in regulating cranial base bone development.
Article
Biochemistry & Molecular Biology
Decheng Ren, Xiaoxi Wei, Lin Lin, Fan Yuan, Yan Bi, Zhenming Guo, Liangjie Liu, Lei Ji, Xiao Yang, Ke Han, Fengping Yang, Xi Wu, Xingwang Li, Zhenghui Yi, Yifeng Xu, Changqun Cai, Peng Wang, Weidong Li, Lin He, Daizhan Zhou, Tao Yu, Yi Shi, Qing Lu, Guang He
Summary: ARID4A plays a crucial role in gene expression and cell proliferation. A new missense mutation in ARID4A, p.His411Asp, was found to be associated with schizophrenia. This mutation alters the conformation and function of ARID4A, leading to disrupted cell cycle arrest and increased cell proliferation.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Shuqun Qi, Yating Wang, Xiaoxi Wei, Di Xie, Rawan Mohsen, Yuan-Lynn Hsieh, Yuji Mishina, Fei Liu
Summary: The cranial base synchondroses are growth centers that drive cranial and upper facial growth. Premature ossification of the intersphenoid synchondrosis (ISS) and spheno-occipital synchondrosis (SOS) in a chondrocyte-specific manner leads to cranial base length reduction and dome-shaped skull. Cre recombinase activity in chondrocytes plays a major role in these abnormalities. The study calls for caution when using Cre in chondrocytes and emphasizes the importance of including appropriate controls in transgenic research.
TRANSGENIC RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Wei Gao, Hongxiang Hu, Lipeng Dai, Miao He, Hebao Yuan, Huixia Zhang, Jinhui Liao, Bo Wen, Yan Li, Maria Palmisano, Mohamed Dit Mady Traore, Simon Zhou, Duxin Sun
Summary: The structure-tissue exposure/selectivity-relationship (STR) is correlated with clinical efficacy/toxicity, while drug exposure in plasma may not be correlated with drug exposure in target tissues. Drug optimization should balance both SAR and STR to improve the success rate of clinical drug development.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Peng Zhang, Zhimin Chen, Henry Kuang, Tongyu Liu, Jiaqiang Zhu, Linkang Zhou, Qiuyu Wang, Xuelian Xiong, Ziyi Meng, Xiaoxue Qiu, Ramiah Jacks, Lu Liu, Siming Li, Carey N. Lumeng, Qing Li, Xiang Zhou, Jiandie D. Lin
Summary: This study reveals that NASH leads to the induction of tumor-associated macrophages and depletion of cytotoxic T cells in the liver. Adipocyte-derived endocrine factor NRG4 plays a role in restraining this pathological reprogramming during NASH. NRG4 deficiency may exacerbate the development of tumor-prone liver immune microenvironment and NASH-related HCC, while NRG4 overexpression could have protective effects in mice. Recombinant NRG4-Fc fusion protein shows remarkable potency in suppressing HCC and prolonging survival in treated mice.
Article
Biochemistry & Molecular Biology
Tao Zhang, Johanna Holman, Delaney McKinstry, Bruno C. Trindade, Kathryn A. Eaton, Jonny Mendoza-Castrejon, Sharon Ho, Emily Wells, Hebao Yuan, Bo Wen, Duxin Sun, Grace Y. Chen, Yanyan Li
Summary: In this study, the researchers investigated the therapeutic effects of steamed broccoli sprouts on colitis using a mouse model of inflammatory bowel disease. Despite the inactivation of the enzyme responsible for producing sulforaphane, measurable levels of sulforaphane were still detected in the colon tissue and feces of mice after consuming steamed broccoli sprouts. Furthermore, steamed broccoli sprouts were found to reduce chemically-induced colitis, and this protective effect was dependent on the presence of a healthy gut microbiota.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Huang Wang, Haibo Du, Rui Ren, Tingting Du, Lin Lin, Zhe Feng, Dange Zhao, Xiaoxi Wei, Xiaoyan Zhai, Hongyang Wang, Tingting Dong, Jin-Peng Sun, Hao Wu, Zhigang Xu, Qing Lu
Summary: In this study, the authors demonstrate that LLPS of the quaternary USH2 protein complex initiates the formation of stereociliary ankle link condensates, providing insights into the pathogenesis of deafness.
NATURE COMMUNICATIONS
(2023)
Article
Physiology
Fei Yang, Xiaoxi Wei, Bo Chen, Chenxi Li, Dong Li, Shugang Zhang, Weigang Lu, Lei Zhang
Summary: This paper proposes a WebGL-based cardiac synergistic modality rendering framework that can visualize the three-dimensional biological modality of the heart and present synergetic correspondence rendering of the cardiac electrophysiological modality. By constructing a biological detailed interactive histogram, users can implement local details rendering for the heart, revealing the cardiac biology details more clearly. Experimental results show that the proposed framework can provide favorable cardiac biological detailed synergetic modality rendering results in terms of both effectiveness and efficiency.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Chemistry, Medicinal
Xinrui Yuan, Hua Jiang, Denggang Fu, Jason C. Rech, Aaron Robida, Krishani Rajanayake, Hebao Yuan, Miao He, Bo Wen, Duxin Sun, Chen Liu, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Sophie Paczesny, Chao-Yie Yang
Summary: Hematopoietic cell transplantation (HCT) is an effective therapy for hematological malignancies and inherited hematological disease, but graft versus host disease (GVHD) is a major concern. Inhibition of sST2 with XY52, a small-molecule ST2 inhibitor, has shown potential in mitigating GVHD progression.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Chemistry, Medicinal
Hongxiang Hu, Mohamed Dit Mady Traore, Ruiting Li, Hebao Yuan, Miao He, Bo Wen, Wei Gao, Colleen B. Jonsson, Elizabeth A. Fitzpatrick, Duxin Sun
Summary: COVID-19 patients with severe symptoms lack effective antiviral treatment options. In this study, a new compound called MMT5-14 showed higher antiviral activity compared to remdesivir, the FDA-approved drug for those patients. MMT5-14 increased the concentration of the drug in the plasma and lungs, enhanced the accumulation of active metabolites in the lungs, and improved uptake and activation in lung epithelial cells. These findings suggest that MMT5-14 could be a potential antiviral drug for severe COVID-19 patients.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Correction
Multidisciplinary Sciences
Hongwei Guo, Hua Luo, Hebao Yuan, Yudui Xia, Pan Shu, Xin Huang, Yi Lu, Xia Liu, Evan T. Keller, Duxin Sun, Jiagang Deng, Jian Zhang
SCIENTIFIC REPORTS
(2021)
Proceedings Paper
Computer Science, Theory & Methods
Xiaoxi Wei, Pablo Ortega, A. Aldo Faisal
Summary: This article discusses the powerful role of convolutional neural networks in decoding EEG and motor imagery EEG brain-computer interface. A new method is proposed to address the negative transfer problem in training CNNs on multiple subjects' EEG, with results showing improved performance.
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2021)
Proceedings Paper
Computer Science, Theory & Methods
Denghao Li, Pablo Ortega, Xiaoxi Wei, Aldo Faisal
Summary: The idea of Meta Learning for training EEG BCI decoders is introduced in this study, showing that it can help systems quickly generalize between different users and recording sessions. Testing on the Physionet EEG motor imagery dataset revealed an increase in classification accuracy between 60 to 80% under the little-data condition compared to other algorithms. The approach of meta learning is believed to aid neural engineering and human interfacing in setting up decoders of neural signals quickly for daily-life suitability.
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2021)
