Review
Medicine, General & Internal
Alexandra-Ioana Trandafir, Oana-Claudia Sima, Ana-Maria Gheorghe, Adrian Ciuche, Anca-Pati Cucu, Claudiu Nistor, Mara Carsote
Summary: Bone fragility is a complication of type 2 diabetes mellitus (T2DM) that has been identified in recent decades. Trabecular bone score (TBS) appears to be more accurate than bone mineral density (BMD) in diabetic bone disease, particularly in menopausal women with T2DM, to independently capture the fracture risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Marco Janner, Christoph Saner
Summary: This paper provides an overview of the impact of type 1 diabetes on bone health in children and adolescents. It discusses various methods, such as dual X-ray absorptiometry and modern non-invasive techniques, for assessing bone health. The paper also explores mechanisms responsible for diabetic bone disease in children and highlights the importance of microvascular disease in the pathophysiology.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Plant Sciences
Reena Rai, Sudhir Kumar, Krishna Bhan Singh, Sonu Khanka, Yatendra Singh, K. R. Arya, Sanjeev Kanojiya, Rakesh Maurya, Divya Singh
Summary: The ethanolic extract and butanolic fraction of Musa paradisiaca flower show potential in preventing bone density loss and promoting bone regeneration, improving bone microarchitecture in postmenopausal conditions. Compounds isolated from the extract exhibit significant osteogenic effects.
Article
Agriculture, Dairy & Animal Science
Xiaotong Li, Jin Zhang, Xianglin Kong, Talaygul Xerenbek, Torkun Mamet
Summary: This study found that yak milk can improve bone density and microarchitecture in osteoporotic mice by inhibiting bone resorption. It also showed that yak milk significantly reduces bone turnover markers and improves bone volume and biomechanical properties.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Medicine, General & Internal
Yui Ogiso, Tatsunori Hanai, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This cross-sectional study aimed to determine whether TBS can identify patients with liver cirrhosis that are at risk of vertebral fractures. The results showed a significant correlation between TBS and vertebral fractures, indicating that TBS can help identify patients at risk of vertebral fractures in liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Matthias Walle, Danielle E. Whittier, Morten Frost, Ralph Mueller, Caitlyn J. Collins
Summary: Diabetes mellitus is associated with changes in bone microarchitecture, with T1DM primarily affecting trabecular bone and T2DM mainly impacting cortical bone. Adverse effects are more pronounced at the radius, suggesting mechanical loading may mitigate these changes. Identifying bone structure abnormalities in T1DM and T2DM could aid in developing animal models for skeletal fragility in diabetes.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Endocrinology & Metabolism
Elliot Ballato, F. N. U. Deepika, Vittoria Russo, Alcibiades Fleires-Gutierrez, Georgia Colleluori, Virginia Fuenmayor, Rui Chen, Dennis T. Villareal, Clifford Qualls, Reina Armamento-Villareal
Summary: This study found that poor glycemic control in men with T2DM is associated with poorer bone quality and reduced bone turnover, while good glycemic control appears to attenuate the impairment in bone quality.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Hsin-Hui Lin, Hsin-Yin Hsu, Ming-Chieh Tsai, Le-Yin Hsu, Kuo-Liong Chien, Tzu-Lin Yeh
Summary: This retrospective cohort study in Taiwan found that patients with type 2 diabetes had a higher risk of osteoporosis, especially among younger participants. There was no significant difference in risk based on sex, but age did have a marginal effect on the relationship between type 2 diabetes and osteoporosis risk.
Article
Endocrinology & Metabolism
Lilian Sewing, Laura Potasso, Sandra Baumann, Denis Schenk, Furkan Gazozcu, Kurt Lippuner, Marius Kraenzlin, Philippe Zysset, Christian Meier
Summary: Type 1 diabetes (T1DM) is associated with an increased risk of nonvertebral fractures, and the influence of glycemic control and microvascular disease on skeletal health in long-standing T1DM is not well understood. This study found that patients with long-standing T1DM had lower bone mineral density (BMD), decreased bone turnover, and weaker bones at the ultradistal tibia compared to non-diabetic controls. The presence of diabetic peripheral neuropathy was found to contribute to the altered cortical microarchitecture and reduced bone strength in T1DM patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Tatiane Vilaca, Margaret Paggiosi, Jennifer S. Walsh, Dinesh Selvarajah, Richard Eastell
Summary: The study found that fracture risk is increased in type 1 diabetes patients, and diabetic neuropathy may contribute to this. Patients with neuropathy had poorer performance in bone structure and physical tests compared to the control group.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Camila Romero-Diaz, Daniela Duarte-Montero, Sebastian A. Gutierrez-Romero, Carlos O. Mendivil
Summary: Diabetes has a significant impact on bone health, with both T1D and T2D associated with a higher risk of fractures through different mechanisms. Chronic hyperglycemia induces non-enzymatic glycation of collagen, increasing the risk of fractures. Timely monitoring of fracture risk and appropriate treatment can greatly reduce the risk of fractures in diabetic patients.
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Elena Tsourdi, Gaia Tabacco, Anda Mihaela Naciu, Nicola Napoli, Fabio Vescini, Andrea Palermo
Summary: The study found that there is currently insufficient data to prove the significant impact of bone therapies on glucose metabolism in diabetic patients. It is uncertain whether antiosteoporotic drugs have different effects on fracture incidence between diabetic and nondiabetic patients. More research is needed to address these issues and provide stronger recommendations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
JunWei Sun, Qi Liu, Huan He, Lanlan Jiang, Kok Onn Lee, Dongmei Li, Jianhua Ma
Summary: This study investigated the association between metformin and bone mineral density (BMD) in Chinese patients with type 2 diabetes mellitus (T2DM). The results showed that metformin use was associated with a lower prevalence of osteoporosis and osteopenia, especially in women. Metformin treatment was independently associated with higher BMD and a lower odds ratio of osteoporosis and low BMD.
DIABETES & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Dalia Ali, Michaela Tencerova, Florence Figeac, Moustapha Kassem, Abbas Jafari
Summary: Osteoporosis is a skeletal disease characterized by decreased bone mass and micro-architectural deterioration, increasing the risk of fractures. Obesity and Type 2 Diabetes (T2D) can contribute to bone fragility in the elderly population by causing metabolic disturbances. These metabolic complications are associated with impaired bone homeostasis and higher fracture risk, with the expansion of Bone Marrow Adipose Tissue (BMAT) being a key mechanism underlying osteoporosis and bone fragility in obesity and T2D. This review provides an overview of the mechanisms behind increased Bone Marrow Adiposity (BMA) during aging and highlights the connection between obesity, T2D, BMA, and bone fragility in aging osteoporotic individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Ilias D. Vachliotis, Stergios A. Polyzos
Summary: The purpose of this review is to summarize the evidence on the potential involvement of the OPG/RANKL/RANK axis in the pathogenesis of metabolic diseases. Recent findings suggest that this axis, originally associated with bone remodeling and osteoporosis, may also play a role in obesity and its associated comorbidities such as type 2 diabetes mellitus and nonalcoholic fatty liver disease. OPG and RANKL are produced in adipose tissue and may be involved in the inflammatory process associated with obesity. Clinical studies have shown associations between OPG and RANKL levels and metabolic dysfunction. Further investigation is needed to understand the mechanisms and potential therapeutic implications of this axis.
CURRENT OBESITY REPORTS
(2023)
Article
Endocrinology & Metabolism
Ditte Neess, Vibeke Kruse, Ann-Britt Marcher, Mie Rye Waede, Julie Vistisen, Pauline M. Moller, Rikke Petersen, Jonathan R. Brewer, Tao Ma, Georgia Colleluori, Ilenia Severi, Saverio Cinti, Zach Gerhart-Hines, Susanne Mandrup, Nils J. Faergeman
Summary: The loss of ACBP in keratinocytes leads to increased energy expenditure, food intake, browning of adipose tissue, and resistance to diet-induced obesity. These findings highlight the crucial role of the epidermal barrier in maintaining systemic metabolic homeostasis.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Georgia Colleluori, Jessica Perugini, Giorgio Barbatelli, Saverio Cinti
Summary: The mammary gland is an exocrine gland responsible for milk production in female mammals, composed mainly of epithelial cells and adipocytes. It displays highly plastic properties during different stages of the lactation cycle and requires close association with adipocytes for proper development. The role of adipocytes in mammary gland development and diseases like obesity and breast cancer deserves further investigation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Geriatrics & Gerontology
Georgia Colleluori, Dennis T. Villareal
Summary: The increasing number of older adults and obesity prevalence highlights the importance of interventions focusing on diet and exercise. Diet-induced weight loss may exacerbate age-related sarcopenia and frailty. Successful strategies to preserve lean and bone mass while reducing fat mass are critical to address physical and metabolic complications related to aging and obesity.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ilenia Severi, Marco Fosca, Georgia Colleluori, Federico Marini, Luca Imperatori, Martina Senzacqua, Angelica Di Vincenzo, Giorgio Barbatelli, Fabrizio Fiori, Julietta Rau, Antonio Giordano
Summary: 【High-fat diet can lead to hypothalamic dysfunction, affecting areas regulating energy balance like the arcuate nucleus and median eminence. Research discovered early structural and chemical changes in ME beta(2)-tanycytes in response to high-fat diet, highlighting a potential impact on obesity.】
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Georgia Colleluori, Laura Graciotti, Mauro Pesaresi, Angelica Di Vincenzo, Jessica Perugini, Eleonora Di Mercurio, Sara Caucci, Patrizia Bagnarelli, Cristina M. Zingaretti, Enzo Nisoli, Stefano Menzo, Adriano Tagliabracci, Annie Ladoux, Christian Dani, Antonio Giordano, Saverio Cinti
Summary: This study confirms the presence of lung fat embolism in COVID-19 patients and describes novel COVID-19-related features possibly contributing to the unfavorable prognosis in individuals with COVID-19 and obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Review
Cell Biology
Georgia Colleluori, Chiara Galli, Ilenia Severi, Jessica Perugini, Antonio Giordano
Summary: Obesity disease is caused by dysfunctional energy balance regulation, with the central nervous system as the master regulator. During early postnatal periods, when the brain is highly plastic and influenced by the environment, neural circuitry involved in this regulation matures. This phenomenon is considered an evolutionary strategy, adjusting metabolic functions to environmental cues. Individuals who experience early life stress (ELS) have a higher prevalence of obesity. Oxytocin plays a vital role in regulating energy balance and is closely linked to leptin. Both oxytocin and leptin impact neurodevelopment and are affected by ELS and obesity.
Article
Multidisciplinary Sciences
Margo P. Emont, Christopher Jacobs, Adam L. Essene, Deepti Pant, Danielle Tenen, Georgia Colleluori, Angelica Di Vincenzo, Anja M. Jorgensen, Hesam Dashti, Adam Stefek, Elizabeth McGonagle, Sophie Strobel, Samantha Laber, Saaket Agrawal, Gregory P. Westcott, Amrita Kar, Molly L. Veregge, Anton Gulko, Harini Srinivasan, Zachary Kramer, Eleanna De Filippis, Erin Merkel, Jennifer Ducie, Christopher G. Boyd, William Gourash, Anita Courcoulas, Samuel J. Lin, Bernard T. Lee, Donald Morris, Adam Tobias, Amit Khera, Melina Claussnitzer, Tune H. Pers, Antonio Giordano, Orr Ashenberg, Aviv Regev, Linus T. Tsai, Evan D. Rosen
Summary: White adipose tissue, once considered bland, is now seen as dynamic, plastic and involved in various biological processes. High-fat feeding and other metabolic stressors lead to significant changes in adipose tissue, linked to insulin resistance, dyslipidemia and type 2 diabetes. Research provides detailed cellular atlases of human and mouse adipose tissue, highlighting interactions between different cell types in lean and obese states.
Article
Endocrinology & Metabolism
Alessandra Celli, Yoann Barnouin, Bryan Jiang, Dean Blevins, Georgia Colleluori, Sanjay Mediwala, Reina Armamento-Villareal, Clifford Qualls, Dennis T. Villareal
Summary: A lifestyle intervention strategy is highly successful in improving metabolic and functional health of older adults with diabetes.
Article
Endocrinology & Metabolism
F. N. U. Deepika, Elliot Ballato, Georgia Colleluori, Lina Aguirre, Rui Chen, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: Male hypogonadism negatively affects body composition, bone mineral density, and metabolic health. This study found that men with a baseline testosterone level of <264 ng/dl showed greater improvement in fat-free mass with testosterone therapy, while men with a testosterone level of >=264 ng/dl showed better improvement in metabolic profile.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Luisa Barana, Georgia Colleluori, Maria Teresa Sulpizi, Kathleen Ortenzi, Luca Farano, Carmine Giuseppe Fanelli, Riccardo Calafiore, Laura Dalla Ragione, Simone Pampanelli
Summary: The study demonstrates that psycho-nutritional treatment is effective in controlling weight and managing blood sugar in individuals with obesity and dysfunctional eating habits who have type 2 diabetes.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Review
Endocrinology & Metabolism
Georgia Colleluori, Dennis T. Villareal
Summary: This review highlights the need for effective strategies to treat complications related to aging and obesity in older adults with obesity. Calorie restriction is effective in reducing fat mass, but exercise, including both aerobic and resistance training, is crucial for improving functional outcomes and preventing muscle and bone loss. When combined with testosterone therapy, lifestyle intervention can preserve muscle and bone mass in older adults with obesity and hypogonadism. Overall, a comprehensive lifestyle intervention involving calorie restriction and exercise provides the greatest improvements in health outcomes and quality of life.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Review
Biochemistry & Molecular Biology
Elisabetta Grillo, Cosetta Ravelli, Georgia Colleluori, Francesco D'Agostino, Mattia Domenichini, Antonio Giordano, Stefania Mitola
Summary: Gremlin-1 is a secreted bone morphogenetic protein antagonist involved in tissue formation, embryonic development, wound healing, inflammation, cancer, and tissue fibrosis. It interacts with BMPs, VEGFR2, and HSPGs to exert its activities. Gremlin-1 also plays a central role in adipose tissue homeostasis and is implicated in metabolic disorders such as type 2 diabetes, obesity, and NAFLD. This review highlights recent findings on gremlin-1's involvement in adipose tissue biology, emphasizing its potential as a prognostic marker and therapeutic target.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
A. Giordano, F. Cinti, R. Canese, G. Carpinelli, G. Colleluori, A. Di Vincenzo, G. Palombelli, I Severi, M. Moretti, C. Redaelli, J. Partridge, M. C. Zingaretti, A. Agostini, F. Sternardi, A. Giovagnoni, S. Castorina, S. Cinti
Summary: Obesity is a major cause of death worldwide, and understanding the adipose organ is crucial for studying its pathology and formulating therapeutic strategies. This study utilized various techniques such as anatomical dissections and medical imaging to demonstrate that white and brown adipose tissues form a large, unified structure that can be considered a true organ. This finding was confirmed in both mice and humans.
Article
Endocrinology & Metabolism
Elliot Ballato, F. N. U. Deepika, Vittoria Russo, Alcibiades Fleires-Gutierrez, Georgia Colleluori, Virginia Fuenmayor, Rui Chen, Dennis T. Villareal, Clifford Qualls, Reina Armamento-Villareal
Summary: This study found that poor glycemic control in men with T2DM is associated with poorer bone quality and reduced bone turnover, while good glycemic control appears to attenuate the impairment in bone quality.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Vittoria Russo, Georgia Colleluori, Rui Chen, Sanjay Mediwala, Clifford Qualls, Michael Liebschner, Dennis T. Villareal, Reina Armamento-Villareal
Summary: This study aims to evaluate the impact of T therapy on bone health in male veterans with low T and T2D, focusing on changes in bone strength, bone turnover markers, circulating osteoblast progenitors (COP) and osteoclast precursors cells. We expect that T therapy will improve bone strength through enhancement of bone remodeling in patients with hypogonadism and T2D.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2021)