Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone

Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer

(2016) Yang Cao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells

(2016) Midori A. Arai et al.   Chemical Science

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

(2015) Margaret M. Mc Gee   MEDIATORS OF INFLAMMATION

Dynamic expression and roles of Hes factors in neural development

(2014) Ryoichiro Kageyama et al.   CELL AND TISSUE RESEARCH

Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma

(2014) Zhou Luan et al.   Molecular Cancer

Inhibition of Microtubule Assembly by a Complex of Actin and Antitumor Macrolide Aplyronine A

(2013) Masaki Kita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Small Molecule Hes1 Modulators as Potential Anticancer Chemotherapeutics

(2012) Vibhavari Sail et al.   Chemical Biology & Drug Design

Role of Cyclin B1/Cdc2 Up-Regulation in the Development of Mitotic Prometaphase Arrest in Human Breast Cancer Cells Treated with Nocodazole

(2011) Hye Joung Choi et al.   PLoS One

Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology

(2010) Natasha Thorne et al.   CHEMISTRY & BIOLOGY

Prohibitins Are Required for Cancer Cell Proliferation and Adhesion

(2010) Claudia Sievers et al.   PLoS One

The first Hes1 dimer inhibitors from natural products

(2009) Midori A. Arai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Notch Target GeneHes1Regulates Cell Cycle Inhibitor Expression in the Developing Pituitary

(2009) Pamela Monahan et al.   ENDOCRINOLOGY

Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma

(2009) Ruben Plentz et al.   GASTROENTEROLOGY

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prohibitin regulates TGF-β induced apoptosis as a downstream effector of smad-dependent and -independent signaling

(2009) Brian Zhu et al.   PROSTATE

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Design of Peptide Inhibitors for the Importin α/β Nuclear Import Pathway by Activity-Based Profiling

(2008) Shunichi Kosugi et al.   CHEMISTRY & BIOLOGY

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

(2008) C. Merkwirth et al.   GENES & DEVELOPMENT

Inhibition of Cortical Neuron Differentiation by Groucho/TLE1 Requires Interaction with WRPW, but Not Eh1, Repressor Peptides

(2008) Manuel Buscarlet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α

(2008) Shunichi Kosugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

(2008) Jonas Sjölund et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA