Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones
出版年份 2018 全文链接
标题
Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 293, Issue 10, Pages 3562-3587
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2018-01-06
DOI
10.1074/jbc.m116.772699
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy
- (2017) Lei Shi et al. FREE RADICAL BIOLOGY AND MEDICINE
- Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
- (2016) Danuta S. Kalinowski et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance
- (2016) Nicole Seebacher et al. FREE RADICAL BIOLOGY AND MEDICINE
- Zinc(II)–Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity
- (2016) Alexandra E. Stacy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure–Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance
- (2016) Alexandra E. Stacy et al. JOURNAL OF MEDICINAL CHEMISTRY
- The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells
- (2016) GUANGLEI YANG et al. Molecular Medicine Reports
- A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC
- (2016) Nicole A Seebacher et al. Cell Death & Disease
- Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics
- (2015) N A Seebacher et al. BRITISH JOURNAL OF PHARMACOLOGY
- Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)
- (2015) Patric J. Jansson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter
- (2015) Nicole A. Seebacher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cancer Microenvironment and Endoplasmic Reticulum Stress Response
- (2015) Claudia Giampietri et al. MEDIATORS OF INFLAMMATION
- The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the “Triad of Death” in cancer by Di-2-pyridylketone thiosemicarbazones
- (2015) Patric J. Jansson et al. PHARMACOLOGICAL RESEARCH
- Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response
- (2014) S R McKeown BRITISH JOURNAL OF RADIOLOGY
- HIF-1α activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells
- (2014) ARATA NISHIMOTO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- A Proteolytic Cascade Controls Lysosome Rupture and Necrotic Cell Death Mediated by Lysosome-Destabilizing Adjuvants
- (2014) Jürgen Brojatsch et al. PLoS One
- P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration
- (2013) Tetsuo Yamagishi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signals from the lysosome: a control centre for cellular clearance and energy metabolism
- (2013) Carmine Settembre et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast
- (2012) Sophie Doublier et al. BMC CANCER
- Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma
- (2012) Y.-L. Hu et al. CANCER RESEARCH
- Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors
- (2012) Chan Yeom et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis
- (2012) Yanyan Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo
- (2012) David B. Lovejoy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes
- (2011) D. B. Lovejoy et al. CANCER RESEARCH
- The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review
- (2011) Naseem Akhtar et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance
- (2011) Jason R. Hickok et al. FREE RADICAL BIOLOGY AND MEDICINE
- Novel Thiosemicarbazone Iron Chelators Induce Up-Regulation and Phosphorylation of the Metastasis Suppressor N-myc Down-Stream Regulated Gene 1: A New Strategy for the Treatment of Pancreatic Cancer
- (2011) Z. Kovacevic et al. MOLECULAR PHARMACOLOGY
- The tumor microenvironment
- (2011) Cynthia E. Weber et al. SURGICAL ONCOLOGY-OXFORD
- How does PKMζ maintain long-term memory?
- (2010) Todd C. Sacktor NATURE REVIEWS NEUROSCIENCE
- Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
- (2010) Andrew Burgess et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Subcellular targeting strategies for drug design and delivery
- (2009) Lawrence Rajendran et al. NATURE REVIEWS DRUG DISCOVERY
- Clioquinol targets zinc to lysosomes in human cancer cells
- (2008) Haijun Yu et al. BIOCHEMICAL JOURNAL
- Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line
- (2008) L. Murphy et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Zinc and 4-Hydroxy-2-Nonenal Mediate Lysosomal Membrane Permeabilization Induced by H2O2 in Cultured Hippocampal Neurons
- (2008) J. J. Hwang et al. JOURNAL OF NEUROSCIENCE
- Lysosomal membrane permeabilization in cell death
- (2008) P Boya et al. ONCOGENE
- ABC multidrug transporters: structure, function and role in chemoresistance
- (2007) Frances J Sharom PHARMACOGENOMICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started