Article
Chemistry, Applied
Verena Christina Tabea Peters, Andreas Dunkel, Oliver Frank, Brian McCormack, Eric Dowd, John Didzbalis, Corinna Dawid, Thomas Hofmann
Summary: A new quick and high-throughput toolbox based on bead-beater homogenization and UHPLC-MS/MS analysis has been developed to quantify 59 flavor-active metabolites in mint leaves and distilled oils, revealing key pathways of mint flavor biosynthesis.
Article
Biochemical Research Methods
Karnrawee Kaewkhao, Joel Tarning, Daniel Blessborn
Summary: Amodiaquine, used for treating malaria, was quantified with its metabolite using liquid chromatography tandem-mass spectrometry. The method showed high accuracy and stability, making it suitable for clinical trials evaluation.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jonathan Tran, Aaron C. Elkins, German C. Spangenberg, Simone J. Rochfort
Summary: This study presents a rapid and high-throughput liquid chromatography-mass spectrometry method for quantitating cannabinoids. The method covers 16 different cannabinoid compounds and achieves faster analysis compared to existing methods mentioned in the literature.
Article
Chemistry, Analytical
Qianyang Huang, Shiying Hao, Xiaoming Yao, Jin You, Xiao Li, Donghai Lai, Chunle Han, James Schilling, Kuo Yuan Hwa, Sheeno Thyparambil, John Whitin, Harvey J. Cohen, Henry Chubb, Scott R. Ceresnak, Doff B. McElhinney, Ronald J. Wong, Gary M. Shaw, David K. Stevenson, Karl G. Sylvester, Xuefeng B. Ling
Summary: This study developed a high-throughput liquid chromatography-tandem mass spectrometric method for quantifying ceramides and dihydroceramides in human serum, revealing unique temporal gestational patterns of these compounds during pregnancy.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Environmental Sciences
Paulina Lukaszewicz, Piotr Stepnowski, Lukasz P. Halinski
Summary: The widespread use of new generation neonicotinoids in water bodies raises concerns about their persistence and potential ecotoxicological effects. In order to monitor their presence, a method using solid-phase extraction and liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) has been developed. By optimizing the extraction conditions, high absolute recoveries (AR) above 80% were achieved. The method has been validated and proven to be sensitive and selective for the analysis of neonicotinoids in surface water samples.
Article
Agriculture, Multidisciplinary
Thomas Kauz, Andreas Dunkel, Thomas Hofmann
Summary: Cocoa-based products are highly preferred by consumers due to their pleasant aroma and desirable astringent, bitter, and sour taste. The key taste components of cocoa have been identified through sensory analysis and structure elucidation, with alkaloids and 2,5-diketopiperazines identified as the key principles for cocoa bitterness. Research indicates that roasting processing plays a crucial role in the development of cocoa taste profiles, regardless of geographical origin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Bibai Du, Mingjie Shen, Zibin Pan, Chunyou Zhu, Dan Luo, Lixi Zeng
Summary: This study introduced a universal LC-MS/MS method for trace analysis of multiple synthetic phenolic antioxidants (SPAs) in foods, utilizing both ESI and APCI for sensitive analysis. Method performance assessment demonstrated satisfactory accuracy and precision in analyzing SPAs in various food matrices.
Article
Environmental Sciences
Melanie Voigt, Martin Jaeger
Summary: Current research is increasingly focusing on the ecotoxicity of anthropogenic micro-pollutants and their degradation and transformation products. Using QSAR analysis, it became possible to predict the ecotoxicity of individual substances with mere computational effort. Overall, lower toxicity against green algae and invertebrates was predicted for the transformation products.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Analytical
Robert S. Plumb, Lee A. Gethings, Paul D. Rainville, Giorgis Isaac, Robert Trengove, Adam M. King, lan D. Wilson
Summary: Properly implemented metabolic and lipidomic profiling can provide valuable information in various fields including epidemiology, drug toxicology, disease biology and patient stratification. LC/MS has become the preferred technology for these analyses due to its speed, sensitivity, and structural elucidation capabilities. Recent advancements in LC/MS have improved feature detection, laboratory efficiency, data quality, and biomarker identification, which can greatly benefit large-scale clinical studies and biobank collections.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Barbara Benedetti, Jose Sanchez del Pulgar, Gabriella Di Lena, Ginevra Lombardi-Boccia
Summary: An optimized HPLC-APCI-MS method was developed for analyzing bioactive compounds in lipid matrices, achieving a balance between peak resolution and speed within a 25-minute run. The use of multiple reaction monitoring mode helped overcome coelution issues and improve sensitivity in the analysis.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
Yiyang Li, Nyuk Ling Ma, Huiling Chen, Jiateng Zhong, Dangquan Zhang, Wanxi Peng, Su Shiung Lam, Yafeng Yang, Xiaochen Yue, Lijun Yan, Ting Wang, Bjarne Styrishave, Tomasz Maciej Ciesielski, Christian Sonne
Summary: According to the World Health Organization, breast cancer is a common and serious health issue for women. This study focuses on searching for bioactive compounds from plants for breast cancer treatment. By screening plant extracts from Chinese ancient forests, the researchers identified potent extracts from Amur honeysuckle and Nigaki plants. Further experiments showed that these extracts significantly reduced tumor growth and killed breast cancer cells. The study also found that the extracts target and interact with known breast cancer genes, providing new insights for future cancer treatments.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Jinglong Li, Katja M. Shimko, Chang He, Brad Patterson, Richard Bade, Ryan Shiels, Jochen F. Mueller, Kevin Thomas, Jake W. O'Brien
Summary: Environmental antimicrobial pollution and antimicrobial resistance are a threat to both the environment and human health. A direct injection method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the quantification of 109 antimicrobials and their metabolites in wastewater samples. The method was validated and showed good specificity, calibration range, accuracy, precision, and low limits of detection and quantification. It was further evaluated using wastewater samples from 6 Australian treatment plants, detecting 37 analytes in influent and 22 in effluent. The study provides a fast and simple pretreatment procedure for antimicrobial monitoring in wastewater.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Pei-Ting Jiang, Kuan-Lu Wu, Hsueh-Ting Wang, Sung-Fang Chen
Summary: This study investigated and evaluated the applicability of using APCI to detect pesticides, and found that APCI had superior ionization efficiency for certain pesticide groups.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2022)
Article
Environmental Sciences
Mo Awchi, Wouter A. Gebbink, Bjorn J. A. Berendsen, Jonathan P. Benskin, Stefan P. J. van Leeuwen
Summary: The study investigated the occurrence of the PFAS alternative H-PFCAs in surface water in the Netherlands, developed a method for quantitative determination, and found trace levels of H-PFCAs and high concentrations of PFCAs.
Article
Chemistry, Applied
Jiaqi Li, Ye Bi, Yi Zheng, Cuiyan Cao, Long Yu, Zhenyu Yang, Wengang Chai, Jingyu Yan, Jianqiang Lai, Xinmiao Liang
Summary: A high-throughput method was developed for the accurate quantitation of 23 complex human milk oligosaccharides. The method was fast and reliable, and was validated through a large population survey of mothers from different ethnic groups in China.
Article
Plant Sciences
Jacob P. Walsh, Natasha DesRochers, Justin B. Renaud, Keith A. Seifert, Ken K-C Yeung, Mark W. Sumarah
Summary: This study identified a siderophore produced by Ilyonectria for the first time, linking it to disease virulence. Siderophore production was suppressed as iron concentration increased, providing new insights into ginseng root rot research.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemical Research Methods
Aaron Harris, A. Roseborough, Rahul Mor, Ken K-C Yeung, Shawn N. Whitehead
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2020)
Article
Biochemistry & Molecular Biology
Moises Freitas-Andrade, John Bechberger, Jasmine Wang, Ken K. C. Yeung, Shawn N. Whitehead, Rie Shultz Hansen, Christian C. Naus
Article
Biochemistry & Molecular Biology
Natasha DesRochers, Jacob P. Walsh, Justin B. Renaud, Keith A. Seifert, Ken K-C Yeung, Mark W. Sumarah
Article
Biochemistry & Molecular Biology
Megan J. Kelman, Justin B. Renaud, Keith A. Seifert, Jonathan Mack, Ken K-C Yeung, Mark W. Sumarah
Article
Chemistry, Analytical
William Pinsky, Aaron Harris, Austyn D. Roseborough, Wenxuan Wang, Ali R. Khan, Kristina Jurcic, Ken K-C Yeung, Stephen H. Pasternak, Shawn N. Whitehead
Summary: Periventricular white matter hyperintensities (pvWMHs) detected by MRI are associated with increased risk of stroke and dementia. MALDI IMS was used to analyze lipid distribution in formalin-fixed human brain tissues, revealing lipid expression differences between pvWMHs and normal white matter.
ANALYTICAL CHEMISTRY
(2021)
Article
Entomology
Ian M. Scott, Gabrielle Hatten, Yazel Tuncer, Victoria C. Clarke, Kristina Jurcic, Ken K. -C. Yeung
Summary: Surveillance and determination of pesticide resistance mechanisms are essential for resistance management. The study utilized proteomic analysis to identify protein differences in susceptible and resistant strains of Colorado potato beetle (CPB), revealing a potential connection between C-type lectin (CTL) expression and insect immunity response to toxins. The findings suggest a novel approach for pest management through targeting insect immunity pathways and highlight the adaptability of CPB to various challenges including synthetic insecticides.
Article
Biochemical Research Methods
Chaochao Chen, Steven R. Laviolette, Shawn N. Whitehead, Justin B. Renaud, Ken K-C Yeung
Summary: In this study, zinc oxide nanoparticles were investigated as an alternative to titanium dioxide nanoparticles for laser desorption/ionization mass spectrometric imaging of low molecular weight molecules. Zinc oxide nanoparticles dissolved in acidic pH showed similar or better results compared to titanium dioxide nanoparticles in imaging LMWM, with regular acid washes effective in maintaining reproducibility. High-quality images of tissue sections were obtained, predominantly detecting ions as Na+ or K+ adducts in the positive ion mode, with ZnO NP detecting a similar number of LMWM as TiO2 NP.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Engineering, Environmental
Kang Kang, Griffin Loebsack, Tahereh Sarchami, Naomi B. Klinghoffer, Sadegh Papari, Ken K. -C. Yeung, Franco Berruti
Summary: This study focuses on the co-pyrolysis of different biomasses with red mud and investigates the reaction mechanism and characterization of the produced magnetic adsorbents. The findings show that samples prepared at high temperature exhibit the best performance, and cellulose-rich adsorbents have higher adsorption efficacy.
Article
Food Science & Technology
M. J. Kelman, J. B. Renaud, D. Baines, K. K-C Yeung, J. D. Miller, M. W. Sumarah
Summary: Silage, a key component of animal feed in Canada and northern Europe, can contain toxic fungal metabolites and is susceptible to spoilage by yeasts and fungi. This study analyzed silage samples from Canadian dairy goat and cattle farms and identified multiple fungal species and mycotoxins. The findings highlight the importance of implementing best management practices to minimize fungal contamination and mycotoxin deposition to maintain animal health.
WORLD MYCOTOXIN JOURNAL
(2022)
Article
Neurosciences
Mohammed H. Sarikahya, Samantha Cousineau, Marta De Felice, Kendrick Lee, Karen Kw Wong, Marieka V. DeVuono, Tony Jung, Mar Rodriguez-Ruiz, Tsun Hay Jason Ng, Dana Gummerson, Emma Proud, Daniel B. Hardy, Ken K-C Yeung, Walter Rushlow, Steven R. Laviolette
Summary: Despite increased prevalence of maternal cannabis use, little is understood regarding potential long-term effects of prenatal cannabis exposure (PCE) on neurodevelopmental outcomes. This study found that PCE induces behavioral, neuronal, and molecular alterations in the mesolimbic system in male and female offspring, resembling neuropsychiatric endophenotypes. Moreover, PCE resulted in profound dysregulation of critical fatty acid pathways in the developing brain lipidome.
Article
Neurosciences
Marta De Felice, Chaochao Chen, Mar Rodriguez-Ruiz, Hanna J. Szkudlarek, Michael Lam, Selvi Sert, Shawn N. Whitehead, Ken K-C Yeung, Walter J. Rushlow, Steven R. Laviolette
Summary: This study used an integrative approach to investigate the effects of adolescent THC exposure on the dorsal and ventral regions of the hippocampus. The findings reveal long-lasting memory deficits and anxiety-like behaviors, as well as differential molecular and neuronal abnormalities in these hippocampal regions. Additionally, the study demonstrates dysregulation of GABA and glutamate levels, as well as glutamatergic signaling in the dorsal and ventral regions of the hippocampus.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Jacob P. Walsh, Christopher P. Garnham, Ken K-C Yeung, Mark W. Sumarah
Summary: This translated article describes a decrease in crop yields caused by ginseng root rot, and highlights the important role of TAFC in the virulence of the ginseng pathogens. The results demonstrate that enzymatic degradation of TAFC can effectively control ginseng root rot.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Kendrick Lee, Mohammed H. Sarikahya, Tony Jung, Samantha L. Cousineau, Ken K. -C. Yeung, Steven R. Laviolette, Daniel B. Hardy
REPRODUCTIVE SCIENCES
(2022)
Meeting Abstract
Clinical Neurology
Moises Freitas-Andrade, John F. Bechberger, Jasmine S-H Wang, Ken K-C Yeung, Shawn N. Whitehead, Rie Schultz Hansen, Christian Naus
INTERNATIONAL JOURNAL OF STROKE
(2019)