What has changed in the treatment of invasive candidiasis? A look at the past 10 years and ahead

Echinocandin prophylaxis in patients undergoing haematopoietic cell transplantation and other treatments for haematological malignancies

(2018) David J Epstein et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

We can do better: a fresh look at echinocandin dosing

(2018) Justin C Bader et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Use of echinocandin prophylaxis in solid organ transplantation

(2018) Maddalena Giannella et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The risk and clinical outcome of candidemia depending on underlying malignancy

(2017) Olivier Lortholary et al.   INTENSIVE CARE MEDICINE

Intensive care medicine research agenda on invasive fungal infection in critically ill patients

(2017) Matteo Bassetti et al.   INTENSIVE CARE MEDICINE

Nosocomial fungemia by Candida auris: First four reported cases in continental Europe

(2017) Alba Cecilia Ruiz Gaitán et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

Notes from the Field: Ongoing Transmission of Candida auris in Health Care Facilities — United States, June 2016–May 2017

(2017) Sharon Tsay et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

(2016) Voon Ong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Propensity Score Analysis of the Role of Initial Antifungal Therapy in the Outcome of Candida glabrata Bloodstream Infections

(2016) M. Puig-Asensio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CD101: a novel long-acting echinocandin

(2016) Yanan Zhao et al.   CELLULAR MICROBIOLOGY

Emergence ofCandida auris: An International Call to Arms

(2016) Cornelius J. Clancy et al.   CLINICAL INFECTIOUS DISEASES

Simultaneous Emergence of Multidrug-ResistantCandida aurison 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses

(2016) Shawn R. Lockhart et al.   CLINICAL INFECTIOUS DISEASES

Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

(2016) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Empirical and targeted therapy of candidemia with fluconazole versus echinocandins: a propensity score–derived analysis of a population-based, multicentre prospective cohort

(2016) L.E. López-Cortés et al.   CLINICAL MICROBIOLOGY AND INFECTION

Lower sensitivity of serum (1,3)-β- d -glucan for the diagnosis of candidaemia due to Candida parapsilosis

(2016) M. Mikulska et al.   CLINICAL MICROBIOLOGY AND INFECTION

Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) for rapid identification of micro-organisms in the routine clinical microbiology laboratory

(2016) C. Wattal et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Contemporary Strategies in the Prevention and Management of Fungal Infections

(2016) Philipp Koehler et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Epidemiology, microbiology, clinical characteristics, and outcomes of candidemia in internal medicine wards—a retrospective study

(2016) Noa Eliakim-Raz et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure

(2016) Jean-Francois Timsit et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD101, a novel echinocandin with exceptional stability properties and enhanced aqueous solubility

(2016) B Radha Krishnan et al.   JOURNAL OF ANTIBIOTICS

The current treatment landscape: candidiasis

(2016) Matteo Bassetti et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, againstCandidaandAspergillusspp., including echinocandin- and azole-resistant isolates

(2016) Michael A. Pfaller et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The epidemiology and outcomes of invasiveCandidainfections among organ transplant recipients in the United States: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)

(2016) David R. Andes et al.   Transplant Infectious Disease

Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study

(2016) Olivier Leroy et al.   Annals of Intensive Care

Investigation of the First Seven Reported Cases ofCandida auris,a Globally Emerging Invasive, Multidrug-Resistant Fungus — United States, May 2013–August 2016

(2016) Snigdha Vallabhaneni et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Failure of Empirical Systemic Antifungal Therapy in Mechanically Ventilated Critically Ill Patients

(2015) Sébastien Bailly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epidemiology and Outcome of Fungemia in a Cancer Cohort of the Infectious Diseases Group (IDG) of the European Organization for Research and Treatment of Cancer (EORTC 65031)

(2015) Oliver A. Cornely et al.   CLINICAL INFECTIOUS DISEASES

T2 Magnetic Resonance Assay for the Rapid Diagnosis of Candidemia in Whole Blood: A Clinical Trial

(2015) Eleftherios Mylonakis et al.   CLINICAL INFECTIOUS DISEASES

Role of Echinocandins in Fungal Biofilm–Related Disease: Vascular Catheter–Related Infections, Immunomodulation, and Mucosal Surfaces

(2015) Aspasia Katragkou et al.   CLINICAL INFECTIOUS DISEASES

Invasive Candida infections in surgical patients in intensive care units: a prospective, multicentre survey initiated by the European Confederation of Medical Mycology (ECMM) (2006–2008)

(2015) L. Klingspor et al.   CLINICAL MICROBIOLOGY AND INFECTION

Initial antifungal strategy does not correlate with mortality in patients with candidemia

(2015) R. Murri et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data

(2015) Sébastien Bailly et al.   INTENSIVE CARE MEDICINE

β-d-Glucan and Candida albicans germ tube antibody in ICU patients with invasive candidiasis

(2015) Estrella Martín-Mazuelos et al.   INTENSIVE CARE MEDICINE

The novel arylamidine T-2307 demonstratesin vitroandin vivoactivity against echinocandin-resistantCandida glabrata

(2015) Nathan P. Wiederhold et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Combination ofCandidabiomarkers in patients receiving empirical antifungal therapy in a Spanish tertiary hospital: a potential role in reducing the duration of treatment

(2015) M. Carmen Martínez-Jiménez et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

1,3-β-d-Glucan contamination of common antimicrobials: Table 1.

(2015) B. Liss et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

1,3-ß-D-glucan concentrations in blood products predict false positive post-transfusion results

(2015) B. Liss et al.   MYCOSES

Invasive Candidiasis

(2015) Bart Jan Kullberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacodynamic Target Evaluation of a Novel Oral Glucan Synthase Inhibitor, SCY-078 (MK-3118), Using anIn VivoMurine Invasive Candidiasis Model

(2014) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Abdominal Candidiasis Is a Hidden Reservoir of Echinocandin Resistance

(2014) Ryan K. Shields et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of an early step-down strategy from intravenous anidulafungin to oral azole therapy for the treatment of candidemia and other forms of invasive candidiasis: results from an open-label trial

(2014) Jose Vazquez et al.   BMC INFECTIOUS DISEASES

MSG-01: A Randomized, Double-Blind, Placebo-Controlled Trial of Caspofungin Prophylaxis Followed by Preemptive Therapy for Invasive Candidiasis in High-Risk Adults in the Critical Care Setting

(2014) L. Ostrosky-Zeichner et al.   CLINICAL INFECTIOUS DISEASES

FKS Mutant Candida glabrata: Risk Factors and Outcomes in Patients With Candidemia

(2014) N. D. Beyda et al.   CLINICAL INFECTIOUS DISEASES

Molecular and Nonmolecular Diagnostic Methods for Invasive Fungal Infections

(2014) M. Arvanitis et al.   CLINICAL MICROBIOLOGY REVIEWS

Effects of Empiric Antifungal Therapy for Septic Shock on Time to Appropriate Therapy for Candida Infection: A Pilot Study

(2014) Scott T. Micek et al.   CLINICAL THERAPEUTICS

Impact of Therapeutic Strategies on the Prognosis of Candidemia in the ICU*

(2014) Mireia Puig-Asensio et al.   CRITICAL CARE MEDICINE

What’s new in the clinical and diagnostic management of invasive candidiasis in critically ill patients

(2014) Cristóbal León et al.   INTENSIVE CARE MEDICINE

A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality

(2014) Matteo Bassetti et al.   INTENSIVE CARE MEDICINE

Clinical validation of a multiplex real-time PCR assay for detection of invasive candidiasis in intensive care unit patients

(2014) J. Fortun et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Potential role of Candida albicans germ tube antibody in the diagnosis of deep-seated candidemia

(2014) M. Carmen Martínez-Jiménez et al.   MEDICAL MYCOLOGY

Our 2014 approach to candidaemia

(2014) Philipp Koehler et al.   MYCOSES

Comparative analysis of Gram's stain, PNA-FISH and Sepsityper with MALDI-TOF MS for the identification of yeast direct from positive blood cultures

(2014) Rebecca L. Gorton et al.   MYCOSES

β-Glucan Antigenemia Anticipates Diagnosis of Blood Culture–Negative Intraabdominal Candidiasis

(2013) Frederic Tissot et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Empirical Fluconazole versus Placebo for Intensive Care Unit Patients

(2013) Mindy G. Schuster   ANNALS OF INTERNAL MEDICINE

Impact of Rapid Organism Identification via Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Combined With Antimicrobial Stewardship Team Intervention in Adult Patients With Bacteremia and Candidemia

(2013) Angela M. Huang et al.   CLINICAL INFECTIOUS DISEASES

An Italian consensus for invasive candidiasis management (ITALIC)

(2013) L. Scudeller et al.   INFECTION

A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts

(2013) Matteo Bassetti et al.   INTENSIVE CARE MEDICINE

Comparison of (1->3)- -D-Glucan, Mannan/Anti-Mannan Antibodies, and Cand-Tec Candida Antigen as Serum Biomarkers for Candidemia

(2013) J. Held et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Septic Shock Attributed to Candida Infection: Importance of Empiric Therapy and Source Control

(2012) M. Kollef et al.   CLINICAL INFECTIOUS DISEASES

(1,3)- -D-Glucan as a Prognostic Marker of Treatment Response in Invasive Candidiasis

(2012) S. Jaijakul et al.   CLINICAL INFECTIOUS DISEASES

Impact of Treatment Strategy on Outcomes in Patients with Candidemia and Other Forms of Invasive Candidiasis: A Patient-Level Quantitative Review of Randomized Trials

(2012) D. R. Andes et al.   CLINICAL INFECTIOUS DISEASES

Performance of Candida Real-time Polymerase Chain Reaction,  -D-Glucan Assay, and Blood Cultures in the Diagnosis of Invasive Candidiasis

(2012) M. H. Nguyen et al.   CLINICAL INFECTIOUS DISEASES

ESCMID* *This guideline was presented in part at ECCMID 2011. European Society for Clinical Microbiology and Infectious Diseases. guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients

(2012) O.A. Cornely et al.   CLINICAL MICROBIOLOGY AND INFECTION

Post-diagnostic kinetics of the (1 → 3)-β-d-glucan assay in invasive aspergillosis, invasive candidiasis and Pneumocystis jirovecii pneumonia

(2012) S. Koo et al.   CLINICAL MICROBIOLOGY AND INFECTION

Anidulafungin for the treatment of candidaemia/invasive candidiasis in selected critically ill patients

(2012) M. Ruhnke et al.   CLINICAL MICROBIOLOGY AND INFECTION

Systemic antifungal therapy in critically ill patients without invasive fungal infection*

(2012) Elie Azoulay et al.   CRITICAL CARE MEDICINE

Value of β-d-glucan and Candida albicans germ tube antibody for discriminating between Candida colonization and invasive candidiasis in patients with severe abdominal conditions

(2012) Cristóbal León et al.   INTENSIVE CARE MEDICINE

Fluconazole versus an echinocandin for Candida glabrata fungaemia: a retrospective cohort study

(2012) G. A. Eschenauer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

β-D-glucan Surveillance with Preemptive Anidulafungin for Invasive Candidiasis in Intensive Care Unit Patients: A Randomized Pilot Study

(2012) Kimberly E. Hanson et al.   PLoS One

Anidulafungin compared with fluconazole for treatment of candidemia and other forms of invasive candidiasis caused by Candida albicans: a multivariate analysis of factors associated with improved outcome

(2011) Annette C Reboli et al.   BMC INFECTIOUS DISEASES

Clinical factors associated with a Candida albicansGerm Tube Antibody positive test in Intensive Care Unit patients

(2011) Javier Pemán et al.   BMC INFECTIOUS DISEASES

Candida Colonization Index in Patients Admitted to an ICU

(2011) Giuseppina Caggiano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent Exposure to Caspofungin or Fluconazole Influences the Epidemiology of Candidemia: a Prospective Multicenter Study Involving 2,441 Patients

(2010) Olivier Lortholary et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New nonculture-based methods for the diagnosis of invasive candidiasis

(2010) Jacques Bille   Current Opinion in Critical Care

Uptake of T-2307, a novel arylamidine, in Candida albicans

(2010) H. Nishikawa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A multicentre study to evaluate the impact of timing of caspofungin administration on outcomes of invasive candidiasis in non-immunocompromised adult patients

(2010) D. I. Hsu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

PCR Diagnosis of Invasive Candidiasis: Systematic Review and Meta-Analysis

(2010) T. Avni et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Prospective Survey of (1->3)- -D-Glucan and Its Relationship to Invasive Candidiasis in the Surgical Intensive Care Unit Setting

(2010) J. F. Mohr et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Impact of Antifungal Prophylaxis on Colonization and Azole Susceptibility of Candida Species

(2009) P. A. Mann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America

(2009) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Preliminary clinical study using a multiplex real-time PCR test for the detection of bacterial and fungal DNA directly in blood

(2009) F. Wallet et al.   CLINICAL MICROBIOLOGY AND INFECTION

Invasive fungal infections and (1,3)-β-d-glucan serum concentrations in long-term intensive care patients

(2009) Elisabeth Presterl et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

A Prospective Clinical Trial of a Real-Time Polymerase Chain Reaction Assay for the Diagnosis of Candidemia in Nonneutropenic, Critically Ill Adults

(2008) R. McMullan et al.   CLINICAL INFECTIOUS DISEASES