Article
Neurosciences
Xi Chen, Kaitlin E. Cassady, Jenna N. Adams, Theresa M. Harrison, Suzanne L. Baker, William J. Jagust
Summary: Studies suggest that tau deposition begins in the anterolateral entorhinal cortex during normal aging and is facilitated by the presence of beta-amyloid, potentially marking the onset of Alzheimer's disease. Higher tau deposition in the anterior-temporal memory network is associated with faster memory decline, especially in individuals with beta-amyloid. When all three tau measures are considered, only tau in the anterior-temporal region significantly predicts memory decline.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Gerontology
Andrew J. Aschenbrenner, Jennifer L. Crawford, Jonathan E. Peelle, Anne M. Fagan, Tammie L. S. Benzinger, John C. Morris, Jason Hassenstab, Todd S. Braver
Summary: Lifelong engagement in cognitively demanding activities can help counteract declines in cognitive ability associated with aging. However, the mental cost of completing cognitive tasks increases with age, possibly due to increased preclinical levels of Alzheimer's disease pathology. In two experiments, researchers found that age-related increases in cognitive effort costs were evident in both working memory and speech comprehension tasks. Additionally, older adults with amyloid burden had higher cognitive effort costs compared to those without amyloid evidence. These findings suggest that cognitive effort costs may be a domain-general trait that increases consistently with aging and can be influenced by neurobiological factors.
PSYCHOLOGY AND AGING
(2023)
Article
Cell Biology
Wanting Liu, Lisa Wing Chi Au, Jill Abrigo, Yishan Luo, Adrian Wong, Bonnie Yin Ka Lam, Xiang Fan, Pauline Wing Lam Kwan, Hon Wing Ma, Anthea Yee Tung Ng, Sirong Chen, Eric Yim Lung Leung, Chi Lai Ho, Simon Ho Man Wong, Winnie C. W. Chu, Ho Ko, Alexander Yuk Lun Lau, Lin Shi, Vincent Chung Tong Mok
Summary: AD-RAI shows potential in detecting early Alzheimer's disease, particularly in the prodromal stage.
Review
Chemistry, Multidisciplinary
Stina Syvanen, Silvio R. Meier, Sahar Roshanbin, Mengfei Xiong, Rebecca Faresjo, Tobias Gustavsson, Gillian Bonvicini, Eva Schlein, Ximena Aguilar, Ulrika Julku, Jonas Eriksson, Dag Sehlin
Summary: Positron emission tomography (PET) is a medical imaging technique that has become important in clinical trials of drugs against Alzheimer's disease (AD). PET data contributed to the approval of aducanumab, an antibody targeting amyloid-beta (A beta) aggregates, by showing a dose-dependent reduction in brain amyloid. PET is also useful in preclinical studies with animal models of A beta pathology. It allows for longitudinal studies and has high translatability between species.
PHARMACEUTICAL RESEARCH
(2022)
Article
Clinical Neurology
Philip S. Insel, Christina B. Young, Paul S. Aisen, Keith A. Johnson, Reisa A. Sperling, Elizabeth C. Mormino, Michael C. Donohue
Summary: The rates of tau accumulation in cognitively unimpaired older adults are subtle and vary in magnitude and spatial patterns. The degree of regional accumulation also likely depends on the amyloid-beta-dependent accumulation. Therefore, it is important to evaluate the pattern and consistency of tau accumulation across multiple cohorts and its relationship with amyloid burden to design optimal tau endpoints for clinical trials.
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.
Review
Pharmacology & Pharmacy
Mohammad Rafi Khezri, Keyvan Yousefi, Negin Mahboubi, Darya Hodaei, Morteza Ghasemnejad-Berenji
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder worldwide, and its association with diseases like diabetes has been well-studied. Metformin, a medication commonly used for type 2 diabetes, has shown potential disease-modifying effects on various aspects of AD pathophysiology.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Psychiatry
Sheng-Min Wang, Nak-Young Kim, Dong Woo Kang, Yoo Hyun Um, Hae-Ran Na, Young Sup Woo, Chang Uk Lee, Won-Myong Bahk, Hyun Kook Lim
Summary: The study found that rs-fMRI may reflect the impact of beta-amyloid pathology on brain activity in the early stages of AD, with functional connectivity maps showing the best classification performance.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Chemistry, Analytical
Houriyeh Sohrabnavi, Mohammad Mohammadimasoudi, Hassan Hajghassem
Summary: This article reports a liquid crystal-based biosensor for the detection of the main biomarker of Alzheimer's disease, amyloid beta protein. The sensor has a fast response time, high specificity, and a low detection limit.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Neurosciences
Essi F. Biyong, Cyntia Tremblay, Manon Leclerc, Vicky Caron, Serge Alfos, Jean-Christophe Helbling, Lea Rodriguez, Vincent Pernet, David A. Bennett, Veronique Pallet, Frederic Calon
Summary: Vitamin A is critical for maintaining memory function with advancing age, and impaired brain Vitamin A signaling may contribute to the onset of Alzheimer's disease. A study found that chronic exposure of 3xTg-AD mice to a Vitamin A-enriched diet may be protective in males but not in females.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Cecilia Tremblay, Geidy E. Serrano, Anthony J. Intorcia, Lucia Sue, Jeffrey R. Wilson, Charles H. Adler, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Thomas G. Beach
Summary: The decline of olfactory function is frequently observed in aging. This study found that tau pathology is commonly observed in the olfactory bulb of normally aging individuals, but it does not independently contribute to age-related olfactory decline. Further involvement of the brain seems to be necessary for age-related olfactory impairment.
Article
Neurosciences
Jenna N. Adams, Theresa M. Harrison, Anne Maass, Suzanne L. Baker, William J. Jagust
Summary: This study aimed to investigate the mechanisms underlying the initial accumulation of tau pathology and the predictive roles of age, AP, and neural activity in tau accumulation. The results showed that older age, higher neural activity, and higher baseline EC tau levels were associated with tau accumulation. Additionally, AP facilitated the spread of tau.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Santiago Bullich, Nuria Roe-Vellve, Marta Marquie, Susan M. Landau, Henryk Barthel, Victor L. Villemagne, Angela Sanabria, Juan Pablo Tartari, Oscar Sotolongo-Grau, Vincent Dore, Norman Koglin, Andre Mueller, Audrey Perrotin, Aleksandar Jovalekic, Susan De Santi, Lluis Tarraga, Andrew W. Stephens, Christopher C. Rowe, Osama Sabri, John P. Seibyl, Merce Boada
Summary: This study aimed to characterize the population with earliest abnormal AP accumulation using F-18-florbetaben PET. Quantitative thresholds for early and established A beta deposition were developed, topography of A beta deposition was assessed, and A beta accumulation over time, progression to AD dementia from MCI, and tau deposition were examined.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Bernard J. Hanseeuw, Rebecca A. Betensky, Elizabeth C. Mormino, Aaron P. Schultz, Jorge Sepulcre, John A. Becker, Heidi I. L. Jacobs, Rachel F. Buckley, Molly R. LaPoint, Patrizia Vannini, Nancy J. Donovan, Jasmeer P. Chhatwal, Gad A. Marshall, Kathryn Papp, Rebecca E. Amariglio, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson
ALZHEIMERS & DEMENTIA
(2018)
Article
Neurosciences
Christopher M. Lee, Heidi I. L. Jacobs, Marta Marquie, John A. Becker, Nicolas V. Andrea, David S. Jin, Aaron P. Schultz, Matthew P. Frosch, Teresa Gomez-Isla, Reisa A. Sperling, Keith A. Johnson
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Neurosciences
Gad A. Marshall, Jennifer R. Gatchel, Nancy J. Donovan, Martha C. Muniz, Aaron P. Schultz, J. Alex Becker, Jasmeer P. Chhatwal, Bernard J. Hanseeuw, Kathryn Papp, Rebecca E. Amariglio, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Clinical Neurology
Bernard J. Hanseeuw, Rebecca A. Betensky, Heidi I. L. Jacobs, Aaron P. Schultz, Jorge Sepulcre, J. Alex Becker, Danielle M. Orozco Cosio, Michelle Farrell, Yakeel T. Quiroz, Elizabeth C. Mormino, Rachel F. Buckley, Kathryn V. Papp, Rebecca A. Amariglio, Ilse Dewachter, Adrian Ivanoiu, Willem Huijbers, Trey Hedden, Gad A. Marshall, Jasmeer P. Chhatwal, Dorene M. Rentz, Reisa A. Sperling, Keith Johnson
Article
Cell Biology
Justin S. Sanchez, J. Alex Becker, Heidi I. L. Jacobs, Bernard J. Hanseeuw, Shu Jiang, Aaron P. Schultz, Michael J. Properzi, Samantha R. Katz, Alexa Beiser, Claudia L. Satizabal, Adrienne O'Donnell, Charles DeCarli, Ron Killiany, Georges El Fakhri, Marc D. Normandin, Teresa Gomez-Isla, Yakeel T. Quiroz, Dorene M. Rentz, Reisa A. Sperling, Sudha Seshadri, Jean Augustinack, Julie C. Price, Keith A. Johnson
Summary: Advances in molecular positron emission tomography have enabled accurate tracking of brain pathology in normal aging and dementia, providing insights into the pathogenesis of Alzheimer's disease. This precise tracking of disease progression is crucial for natural history studies and prevention therapeutic trials.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Justin S. Sanchez, Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzman-Velez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E. Martinez, Joshua T. Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I. L. Jacobs, Aaron P. Schultz, Jennifer R. Gatchel, J. Alex Becker, Samantha R. Katz, Danielle Mayblyum, Julie C. Price, Eric M. Reiman, Keith A. Johnson, Yakeel T. Quiroz
Summary: In ADAD, there are different rates of tau accumulation in various brain regions, with the fastest accumulation in the parietal neocortex. The baseline EC tau PET signal is a significant predictor of subsequent neocortical tau accumulation and cognitive decline within carriers.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Danielle Mayblyum, J. Alex Becker, Heidi I. L. Jacobs, Rachel F. Buckley, Aaron P. Schultz, Jorge Sepulcre, Justin S. Sanchez, Zoe B. Rubinstein, Samantha R. Katz, Kirsten A. Moody, Patrizia Vannini, Kathryn Papp, Dorene M. Rentz, Julie C. Price, Reisa A. Sperling, Keith A. Johnson, Bernard J. Hanseeuw
Summary: This study compared different biomarkers and found that entorhinal hypometabolism is a strong and independent predictor of subsequent cognitive decline in preclinical Alzheimer's disease. Using high PiB and low entorhinal FDG as inclusion criteria significantly reduced the number of participants needed in a hypothetical trial.
Article
Cell Biology
Heidi I. L. Jacobs, John A. Becker, Kenneth Kwong, Nina Engels-Dominguez, Prokopis C. Prokopiou, Kathryn Papp, Michael Properzi, Olivia L. Hampton, Federico d'Oleire Uquillas, Justin S. Sanchez, Dorene M. Rentz, Georges El Fakhri, Marc D. Normandin, Julie C. Price, David A. Bennett, Reisa A. Sperling, Keith A. Johnson
Summary: Various autopsy studies have shown that the locus coeruleus (LC) is the initial site of hyperphosphorylated TAU aggregation, and as TAU accumulates in LC neurons, pathology spreads throughout the cortex. Lower LC integrity is associated with increased TAU deposition in the entorhinal cortex in older individuals, and LC pigmentation ratings correlate with LC neuronal density, particularly in advanced Braak stages. These findings suggest that LC integrity may be a promising indicator of early Alzheimer's disease processes and cognitive changes.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Psychology, Clinical
Jeremy S. Carmasin, Robert M. Roth, Laura A. Rabin, Jessica J. Englert, Laura A. Flashman, Andrew J. Saykin
Summary: In this study, cognitively normal older adults and individuals with prodromal dementia conditions reported stable executive functioning at a 1-year follow-up. Participants with aMCI and SCD, along with their informants, reported worse executive functions compared to CN individuals at both time points. There were no group by time interactions observed in subjective or objective measures of executive function.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Tao Sun, J. Alex Becker, Cristina Lois, Keith Johnson, Georges El Fakhri, Jinsong Ouyang
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Medicine, General & Internal
Jennifer R. Gatchel, Jennifer S. Rabin, Rachel F. Buckley, Joseph J. Locascio, Yakeel T. Quiroz, Hyun-Sik Yang, Patrizia Vannini, Rebecca E. Amariglio, Dorene M. Rentz, Michael Properzi, Nancy J. Donovan, Deborah Blacker, Keith A. Johnson, Reisa A. Sperling, Gad A. Marshall, Jasmeer P. Chhatwal, Bradford Dickerson, Michelle Farrell, Edmarie Guzman Velez, Heidi Jacobs, Cristina Lois Gomez, Kathryn Papp, Julie Price, Jeremy Pruzin, Leaked T. Quiroz, Aaron P. Schultz, Jorge Sepulcre, Irina Skyler-Scott, J. Alex Becker, Randy Buckner, Trey Hedden, Bernard J. Hanseeuw, Willem Hujibers, Scott McGinnis, Elizabeth Mormino, Kelsey Biddle, Colleen Fitzpatrick, Christopher Gonzalez, Hannah Klein, Lyssa Manning, Martha Muniz, Aubryn Samaroo, Paige Sparks, Heirangi Torrico-Teave, Joshua Fuller, Olivia Hampton, Samantha Katz, Kirsten Moody, Danielle Mayblyum, Kelsey Barolak, Zoe Rubinstein, Justin Sanchez, Frederico D'Oleire Uquillas, Dylan Kim, Matthew Scott, Jairo E. Martinez
Meeting Abstract
Clinical Neurology
Elif Gokcal, Panagiotis Fotiadis, J. Alex Becker, Kristin Schwab, Joshua Goldstein, Jonathan Rosand, Anand Viswanathan, Steven M. Greenberg, M. Edip Gurol
Meeting Abstract
Clinical Neurology
Edip M. Gurol, J. Alex Becker, Elif Gokcal, Panagiotis Fotiadis, Kristin M. Schwab, Joshua N. Goldstein, Jonathan Rosand, Anand Viswanathan, Keith A. Johnson, Steve M. Greenberg
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Alvin Ihsani, Joyita Dutta, J. Alex Becker, Keith Alan Johnson, Jinsong Ouyang, Georges El Fakhri
JOURNAL OF NUCLEAR MEDICINE
(2018)
Article
Geriatrics & Gerontology
Jennifer R. Gatchel, Nancy J. Donovan, Joseph J. Locascio, J. Alex Becker, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2017)