Article
Genetics & Heredity
Tao Wang, Yuanyuan Guo, Shengwei Liu, Chaoxin Zhang, Tongyan Cui, Kun Ding, Peng Wang, Xibiao Wang, Zhipeng Wang
Summary: By analyzing the transcriptional data of Tibetan pigs and Rongchang pigs, it was found that lung tissue may play a crucial role in the adaptation of Tibetan pigs to high-altitude hypoxic environments, with some potential regulatory genes identified.
FRONTIERS IN GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Li An, Yanyan Li, Lin Yaq, Yong Wang, Qilin Dai, Shizhang Du, Yi Ru, Qi Zhoucuo, Jinling Wang
Summary: Tibetan sheep, as one of the most important livestock breeds on the Qinghai-Tibet Plateau, play a significant role in the local economy, agriculture, and culture. This study used transcriptome sequencing to analyze the tissues of Tibetan sheep at low and highland altitudes, and identified candidate genes and signaling pathways involved in the adaptation to plateau characteristics. The findings provide a foundation for further research on Tibetan sheep.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yuta Yamaguchi, Yasuhiro Kato, Ryuya Edahiro, Jonas N. Sondergaard, Teruaki Murakami, Saori Amiya, Shinichiro Nameki, Yuko Yoshimine, Takayoshi Morita, Yusuke Takeshima, Shuhei Sakakibara, Yoko Naito, Daisuke Motooka, Yu-Chen Liu, Yuya Shirai, Yasutaka Okita, Jun Fujimoto, Haruhiko Hirata, Yoshito Takeda, James B. Wing, Daisuke Okuzaki, Yukinori Okada, Atsushi Kumanogch
Summary: Consecutive mRNA vaccinations against SARS-CoV-2 enhance innate and adaptive immune responses. This study investigates the role of epigenetic regulation in mediating enhanced innate immune responses and the persistence of these effects. The results show that BNT162b2 mRNA vaccination upregulates antiviral and IFN-stimulated gene expression in monocytes, with greater effects after the second vaccination. However, these effects are transient and disappear 4 weeks after the second vaccination. This study provides novel insights into innate immune memory and its implications for vaccine development.
Article
Biochemistry & Molecular Biology
Susanne Kramer, Natalia Katarzyna Karolak, Johanna Odenwald, Bernardo Gabiatti, Paula Andrea Castaneda Londono, Anna Zavrelova, Eden Ribeiro Freire, Kayo Schemiko Almeida, Silke Braune, Claudia Moreira, Amelie Eder, Carina Goos, Mark Field, Mark Carrington, Fabiola Holetz, Maria Wiktoria Gorna, Martin Zoltner
Summary: The removal of the mRNA 5' cap is essential for controlling gene expression in eukaryotes. Unlike other eukaryotes, kinetoplastida rely on a unique complex involving ALPH1, XRNA, and other proteins for decapping. This complex has a specific and dynamic localization at the posterior pole of the cell. This unique composition sets the trypanosome decapping complex apart from other eukaryotes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Chao Xu, Jing Shi, Rufeng Huang, Zhengchang Wu, Shenglong Wu, Wenbin Bao
Summary: This study investigates the role of lncRNA-mRNA in immune regulation by studying the transcriptome of Meishan pig spleen. A competing endogenous RNA network involving lncRNA-miRNA-mRNA was identified, which may play a critical role in immune regulation of Meishan pigs.
Review
Pharmacology & Pharmacy
Xiaoyu Liao, Yifan Guo, Yumin He, Yanxuan Xiao, Jingyi Li, Rui Liu
Summary: Epigenetic modification and metabolism are closely related in cells, with metabolic enzymes serving as epigenetic regulators. This interaction provides a new perspective for understanding the related processes within organisms.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Genetics & Heredity
Zhengchang Wu, Dongfeng Shi, Jian Jin, Hairui Fan, Wenbin Bao, Shenglong Wu
Summary: This study identified FUT3 as a key gene associated with resistance to E. coli F18 in piglets through transcriptome analysis, and found that the methylation levels of specific CpG sites in the FUT3 promoter can impact its expression and the piglets' resistance to the pathogen.
Article
Cell Biology
Xiangming Fang, Rensheng Song, Jiaxing Wei, Qin Liao, Zhenhong Zeng
Summary: This study aimed to identify effective drug targets and diagnostic models for heart failure (HF) using miRNA targets. Differential miRNAs and genes were analyzed, and miRNA targets were predicted. Gene set enrichment analysis and protein-protein interaction identification were performed. Drug proximity and molecular docking were used for drug identification. Diagnostic models were constructed based on differential miRNAs. The key candidate gene TAP1 and potential inhibitor DB04847 were identified. The TAP1 gene was regulated by hsa-miR-6785-5p and hsa-miR-4443, and a diagnostic model was constructed. This study provides new insights for the diagnosis, prognosis, and treatment of HF.
MEDIATORS OF INFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Pritpal Kaur, Shreya Nagar, Madhura Bhagwat, Mohammad Uddin, Yan Zhu, Ivana Vancurova, Ales Vancura
Summary: Heme synthesis influences cellular energy and anabolism pathways, potentially leading to oxidative stress. Exogenous supplementation of heme precursor ALA can suppress oxidative metabolism and glycolysis in cancer cells, reducing proliferation and destabilizing the transcription regulator Bach1, indicating a promising anti-cancer strategy.
Article
Biochemistry & Molecular Biology
Bjort K. Kragesteen, Amir Giladi, Eyal David, Shahar Halevi, Laufey Geirsdottir, Olga M. Lempke, Baoguo Li, Andreas M. Bapst, Ken Xie, Yonatan Katzenelenbogen, Sophie L. Dahl, Fadi Sheban, Anna Gurevich-Shapiro, Mor Zada, Truong San Phan, Roberto Avellino, Shuang-Yin Wang, Oren Barboy, Shir Shlomi-Loubaton, Sandra Winning, Philipp P. Markwerth, Snir Dekalo, Hadas Keren-Shaul, Merav Kedmi, Martin Sikora, Joachim Fandrey, Thorfinn S. Korneliussen, Josef T. Prchal, Barak Rosenzweig, Vladimir Yutkin, Fernando Racimo, Eske Willerslev, Chamutal Gur, Roland H. Wenger, Ido Amit
Summary: Single-cell RNA and transposase-accessible chromatin (ATAC) sequencing in a mouse model identified a rare cell subset called Norn cells in kidney stroma as the major source of endocrine Epo production in mice, and this finding was confirmed in human kidney tissues. These findings provide new insights into EPO gene regulation and may lead to improved therapies for anemia.
Review
Biochemistry & Molecular Biology
Young Suk Yu, Hyunkyung Kim, Keun Il Kim, Sung Hee Baek
Summary: Autophagy is an evolutionarily conserved catabolic process that degrades redundant components and dysfunctional organelles to protect cells and maintain cellular homeostasis. Epigenetic regulation within the nucleus plays an important role in the regulation of autophagy. When energy homeostasis is disrupted, cells increase autophagic activity at the transcriptional level through epigenetic factors, such as histone-modifying enzymes and histone modifications. Understanding the regulatory mechanisms of autophagy could lead to potential therapeutic targets for autophagy-related diseases.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Daniel F. Clark, Rachael Schmelz, Nicole Rogers, Nuri E. Smith, Kimberly R. Shorter
Summary: The study found that excess folic acid can impact gene expression, epigenetic marks, and neuromorphology even when MTHFR is functioning normally. Folic acid treatment led to changes in gene expression of epigenetic modifying enzymes, alterations in global DNA methylation and hydroxymethylated DNA. Additionally, folic acid affected dendritic spine densities and histone modifications.
Article
Genetics & Heredity
Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu
Summary: High-altitude adaptation in Tibetan pigs is associated with positively-selected genes, with the BNP gene playing a critical role. The C-1780G polymorphic site in the BNP gene is advantageous for high-altitude adaptation in pigs by upregulating BNP expression. This study provides insights into the mechanism underlying the involvement of the BNP gene in high-altitude adaptation.
Article
Biology
Min Hu, Joseph M. Santin
Summary: This study investigates the reorganization of the metabolic transcriptional network in the brainstem of American bullfrogs during hibernation to achieve ischemia tolerance. The results suggest that improving neural performance during ischemia involves a transcriptional program for glycogen and glucose metabolism.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Cheemala Ashok, Neha Ahuja, Subhashis Natua, Jharna Mishra, Atul Samaiya, Sanjeev Shukla
Summary: ESRP1 plays a significant role in cancer progression, with elevated expression in carcinoma in situ and reduced expression in hypoxic cancer cells. The transcription factor E2F1 and CpG hydroxymethylation are key factors in upregulating ESRP1 expression, while hypoxia-induced TET3 downregulation leads to E2F1 repression, contributing to diminished ESRP1 expression in hypoxic conditions.
Article
Evolutionary Biology
Qian Zhang, Wenyu Gou, Xiaotong Wang, Yawen Zhang, Jun Ma, Hongliang Zhang, Ying Zhang, Hao Zhang
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
Bo Zhang, Peng Shang, Yangzong Qiangba, Aishi Xu, Zhixiu Wang, Hao Zhang
LIPIDS IN HEALTH AND DISEASE
(2016)
Article
Agriculture, Dairy & Animal Science
Bo Zhang, Yangzong Qiangba, Peng Shang, Yunfeng Lu, Yuzeng Yang, Zhixiu Wang, Hao Zhang
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2016)
Article
Genetics & Heredity
Bo Zhang, Peng Shang, Zhu Tao, Yangzong Qiangba, Zhixiu Wang, Hao Zhang
Article
Multidisciplinary Sciences
Bo Zhang, Yangzom Chamba, Peng Shang, Zhixiu Wang, Jun Ma, Liyuang Wang, Hao Zhang
SCIENTIFIC REPORTS
(2017)
Article
Agriculture, Dairy & Animal Science
Bo Zhang, Dongmei Ban, Xiao Gou, Yawen Zhang, Lin Yang, Yangzom Chamba, Hao Zhang
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2019)
Article
Genetics & Heredity
Peng Shang, Bo Zhang, Jian Zhang, Mengqi Duan, Lvcao Wu, Xinglong Gong, Keren Tang, Hao Zhang, Yangzom Chamba
Article
Genetics & Heredity
Ying Zhang, Hongliang Zhang, Bo Zhang, Yao Ling, Hao Zhang
Article
Multidisciplinary Sciences
Xiaotong Zheng, Bo Zhang, Yawen Zhang, Haian Zhong, Ruixue Nie, Junying Li, Hao Zhang, Changxin Wu
SCIENTIFIC REPORTS
(2020)
Article
Agriculture, Dairy & Animal Science
Mengqi Duan, Zhenmei Wang, Xinying Guo, Kejun Wang, Siyuan Liu, Bo Zhang, Peng Shang
Summary: Tibetan pigs and Yorkshire pigs exhibit significant differences in transcriptomic and proteomic expression patterns in the liver, with functional enrichment analysis indicating involvement of numerous genes in metabolic processes. Differences were also observed in small molecular biosynthesis, metabolic processes, and organic hydroxyl compound metabolic processes between the two breeds.
Article
Genetics & Heredity
Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu
Summary: High-altitude adaptation in Tibetan pigs is associated with positively-selected genes, with the BNP gene playing a critical role. The C-1780G polymorphic site in the BNP gene is advantageous for high-altitude adaptation in pigs by upregulating BNP expression. This study provides insights into the mechanism underlying the involvement of the BNP gene in high-altitude adaptation.