Article
Agriculture, Multidisciplinary
Zhang Zhe, Chen Zi-tao, Diao Shu-qi, Ye Shao-pan, Wang Jia-ying, Gao Ning, Yuan Xiao-long, Chen Zan-mou, Zhang Hao, Li Jia-qi
Summary: In a genome wide association study on Duroc pigs, 28 potential single nucleotide polymorphisms associated with growth and fatness traits were identified. Genes such as VPS4B and PHLPP1 were highlighted as plausible candidates contributing to the genetic architecture of porcine growth and fatness traits. These findings enhance our understanding of the genetic mechanisms underlying swine growth and fatness traits, with potential application in pig breeding programs.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Agriculture, Dairy & Animal Science
Mei Liu, Qun Lan, Long Yang, Qiuchun Deng, Taiyun Wei, Heng Zhao, Peiya Peng, Xiaoding Lin, Yuhan Chen, Haiming Ma, Hongjiang Wei, Yulong Yin
Summary: The aim of this study was to identify the genetic loci and candidate genes associated with phenotypic traits in DSE pigs using GWAS. Seven SNPs were found to be significantly associated with back height, chest circumference, cannon bone circumference, and backfat thickness. These SNPs were mapped to candidate genes involved in adipocyte differentiation, lipid metabolism, skeletal muscle development, and average daily weight gain. This study provides new insights into the genetic architecture of economically important traits in swine and has implications for molecular marker breeding in the DSE breed.
Article
Agriculture, Dairy & Animal Science
Ales Knoll, Michaela Nesvadbova, Tomas Urban
Summary: NREP gene plays a critical role in muscle transformation in pigs, with higher expression levels in Czech Large White pigs compared to wild boars and positive associations with meat-related traits, suggesting its potential as a marker for selection in improving pork production.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2022)
Article
Genetics & Heredity
Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu
Summary: High-altitude adaptation in Tibetan pigs is associated with positively-selected genes, with the BNP gene playing a critical role. The C-1780G polymorphic site in the BNP gene is advantageous for high-altitude adaptation in pigs by upregulating BNP expression. This study provides insights into the mechanism underlying the involvement of the BNP gene in high-altitude adaptation.
Article
Immunology
Roan E. Zaied, Tayaza Fadason, Justin M. O'Sullivan
Summary: In this study, a network analysis approach was used to construct tissue-specific spatial gene regulatory networks for asthma and identify asthma-associated diseases and their molecular mechanisms. The study also analyzed the comorbidity of asthma with other diseases and identified possible therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Seong-Hoon Kim, Rupesh Tayade, Byeong-Hee Kang, Bum-Soo Hahn, Bo-Keun Ha, Yoon-Ha Kim
Summary: This study conducted a genome-wide association study (GWAS) on 357 soybean landraces to analyze root traits. It identified 112 significant SNP loci and 55 putative candidate genes. These findings suggest that the combined approach of SNP array and GWAS can be used to understand the genetic basis of soybean root traits and improve soybean breeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Zhixiu Wang, Wenshuang Liang, Xiangxiang Li, Yang Zhang, Qi Xu, Guohong Chen, Hao Zhang, Guobin Chang
Summary: Muscle growth rate and muscle mass are important economic traits in animal production. This study investigated the expression of the MUSTN1 gene in Pekin ducks and Cherry Valley ducks, and found that the expression level of MUSTN1 was significantly higher in Pekin ducks at 3 weeks and 6 weeks of age compared to Cherry Valley ducks.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Fisheries
Jiamin Guo, Anqi Wang, Siqi Mao, Xiaoyan Xu, Jiale Li, Yubang Shen
Summary: This study constructed the first high-density genetic linkage map of black carp and identified QTL related to growth traits. The map provides valuable genomic resources for understanding economically important traits in black carp and can be used for comparative genomics and evolutionary studies.
Article
Genetics & Heredity
Zheng Chang Wu, Yifu Wang, Xiaoguo Huang, Shenglong Wu, Wenbin Bao
Summary: Improving the reproductive efficiency of sows is a major challenge in the swine industry. This study identified genetic markers associated with reproductive traits in Large White pigs and suggested the use of marker-assisted selection for genetic improvement.
Article
Agriculture, Dairy & Animal Science
Seyed Mohammad Hadi Safaei, Mohammad Dadpasand, Mohammadreza Mohammadabadi, Hadi Atashi, Ruslana Stavetska, Nataliia Klopenko, Oleksandr Kalashnyk
Summary: Nutrition has a significant impact on the body, especially on genes and gene expression. Origanum majorana (MO) is a nutritional additive with antioxidant, antibacterial, and antifungal properties. This study shows that adding MO to lamb diets can improve growth parameters by affecting the expression of the myogenin gene.
Article
Agriculture, Dairy & Animal Science
Zhixiu Wang, Wenshuang Liang, Dan Yan, Huiyue Tian, Bingqiang Dong, Wenming Zhao, Guobin Chang, Guohong Chen
Summary: This study identified candidate genes related to duck skeletal muscle growth using RNA-sequencing technology and found that these genes are mainly involved in biological processes and pathways of fat metabolism and muscle growth. These findings deepen our understanding of the molecular mechanisms involved in muscle growth in ducks.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Kang Hee Kho, Zahid Parvez Sukhan, Shaharior Hossen, Yusin Cho, Soo Cheol Kim, Md. Rajib Sharker, Hee-Jeong Jung, Ill-Sup Nou
Summary: A high-density linkage map and QTL for three growth-related traits were constructed for Pacific abalone, revealing two significant QTL in the telomere region of the chromosome for each trait and identifying four potential candidate genes for growth regulation.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shi-Xiao Peng, Jingwen Pei, Berardo Rinaldi, Jiang Chen, Yu-Han Ge, Min Jia, Jun Wang, Andree Delahaye-Duriez, Jia-Hui Sun, Yan-Yu Zang, Yong-Yun Shi, Ning Zhang, Xiang Gao, Donatella Milani, Xijia Xu, Nengyin Sheng, Benedicte Gerard, Chen Zhang, Allan Bayat, Na Liu, Jian-Jun Yang, Yun Stone Shi
Summary: The study identified two rare genetic mutations and a genetic polymorphism associated with aggressive behavior. Knocking out the GluA3 gene revealed that abnormal excitability in the brain cortex leads to aggressive behavior.
MOLECULAR PSYCHIATRY
(2022)
Article
Agriculture, Dairy & Animal Science
Yanhong Cao, Peng Jia, Zhuyue Wu, Mingguang Huang, Shaomei Chen, Jicai Zhang, Bizhi Huang, Chuzhao Lei
Summary: A novel missense mutation in the MYO1A gene was found to be associated with heat-tolerance in Chinese indigenous cattle. The allele frequencies at this locus were correlated with the distribution of different climatic conditions in China, and genotypes were significantly correlated with climatic conditions.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Deepali Gupta, Anna M. Patterson, Sherri Osborne-Lawrence, Angie L. Bookout, Salil Varshney, Kripa Shankar, Omprakash Singh, Nathan P. Metzger, Corine P. Richard, Steven C. Wyler, Joel K. Elmquist, Jeffrey M. Zigman
Summary: The study investigated the role of acyl-ghrelin on GH secretion and metabolic actions by selectively deleting GHSR from somatotrophs. Results suggest that the direct engagement of GHSR-expressing somatotrophs is essential for acyl-ghrelin to stimulate GH secretion and influence its metabolic actions.
MOLECULAR METABOLISM
(2021)
Article
Evolutionary Biology
Qian Zhang, Wenyu Gou, Xiaotong Wang, Yawen Zhang, Jun Ma, Hongliang Zhang, Ying Zhang, Hao Zhang
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
Bo Zhang, Peng Shang, Yangzong Qiangba, Aishi Xu, Zhixiu Wang, Hao Zhang
LIPIDS IN HEALTH AND DISEASE
(2016)
Article
Agriculture, Dairy & Animal Science
Bo Zhang, Yangzong Qiangba, Peng Shang, Yunfeng Lu, Yuzeng Yang, Zhixiu Wang, Hao Zhang
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2016)
Article
Multidisciplinary Sciences
Bo Zhang, Yangzom Chamba, Peng Shang, Zhixiu Wang, Jun Ma, Liyuang Wang, Hao Zhang
SCIENTIFIC REPORTS
(2017)
Article
Agriculture, Dairy & Animal Science
Bo Zhang, Dongmei Ban, Xiao Gou, Yawen Zhang, Lin Yang, Yangzom Chamba, Hao Zhang
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2019)
Article
Genetics & Heredity
Peng Shang, Bo Zhang, Jian Zhang, Mengqi Duan, Lvcao Wu, Xinglong Gong, Keren Tang, Hao Zhang, Yangzom Chamba
Article
Genetics & Heredity
Ying Zhang, Hongliang Zhang, Bo Zhang, Yao Ling, Hao Zhang
Article
Multidisciplinary Sciences
Xiaotong Zheng, Bo Zhang, Yawen Zhang, Haian Zhong, Ruixue Nie, Junying Li, Hao Zhang, Changxin Wu
SCIENTIFIC REPORTS
(2020)
Article
Agriculture, Dairy & Animal Science
Mengqi Duan, Zhenmei Wang, Xinying Guo, Kejun Wang, Siyuan Liu, Bo Zhang, Peng Shang
Summary: Tibetan pigs and Yorkshire pigs exhibit significant differences in transcriptomic and proteomic expression patterns in the liver, with functional enrichment analysis indicating involvement of numerous genes in metabolic processes. Differences were also observed in small molecular biosynthesis, metabolic processes, and organic hydroxyl compound metabolic processes between the two breeds.
Article
Genetics & Heredity
Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu
Summary: High-altitude adaptation in Tibetan pigs is associated with positively-selected genes, with the BNP gene playing a critical role. The C-1780G polymorphic site in the BNP gene is advantageous for high-altitude adaptation in pigs by upregulating BNP expression. This study provides insights into the mechanism underlying the involvement of the BNP gene in high-altitude adaptation.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.