Pre-clinical effects of metformin and aspirin on the cell lines of different breast cancer subtypes

Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ERα

(2018) Helen S. Vethakanraj et al.   ANTI-CANCER DRUGS

Targeting AMPK, mTOR and β-Catenin by Combined Metformin and Aspirin Therapy in HCC: An Appraisal in Egyptian HCC Patients

(2017) Doaa Ali Abdelmonsif et al.   Molecular Diagnosis & Therapy

Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β

(2017) Xufeng Tao et al.   Cell Death & Disease

Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells

(2017) Ran Cheng et al.   Oncotarget

Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC)

(2017) Debanjan Tewari et al.   Scientific Reports

Metformin reduces gastric cancer risk in patients with type 2 diabetes mellitus

(2016) Chin-Hsiao Tseng   Aging-US

Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism

(2016) Taelim Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The effect of aspirin and nonsteroidal anti-inflammatory drug use after diagnosis on survival of oesophageal cancer patients

(2016) Jente van Staalduinen et al.   BRITISH JOURNAL OF CANCER

Aspirin use and the incidence of breast, colon, ovarian, and pancreatic cancers in elderly women in the Iowa Women’s Health Study

(2016) Lisa E. Vaughan et al.   CANCER CAUSES & CONTROL

Proteomic modulation in breast tumors after metformin exposure: results from a “window of opportunity” trial

(2016) K. Kalinsky et al.   Clinical & Translational Oncology

SAnDReS a Computational Tool for Statistical Analysis of Docking Results and Development of Scoring Functions

(2016) Mariana Morrone Xavier et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Is aspirin use associated with a decreased risk of ovarian cancer? A systematic review and meta-analysis of observational studies with dose-response analysis

(2016) Dongyu Zhang et al.   GYNECOLOGIC ONCOLOGY

Protective effects of levamisole, acetylsalicylic acid, and α-tocopherol against dioxin toxicity measured as the expression of AhR and COX-2 in a chicken embryo model

(2016) Kinga Gostomska-Pampuch et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling

(2016) Alexander M. Scherbakov et al.   IUBMB LIFE

Impact of metformin on metastases in patients with breast cancer and type 2 diabetes

(2016) Louis Jacob et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Lipoxin A4Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer

(2016) Liang Zong et al.   Oxidative Medicine and Cellular Longevity

Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitro

(2016) ZHEN-YUAN GAO et al.   Experimental and Therapeutic Medicine

Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer

(2016) Sandrine Tury et al.   Oncotarget

Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells

(2016) Giovanna Talarico et al.   Scientific Reports

Aspirin Breaks the Crosstalk between 3T3-L1 Adipocytes and 4T1 Breast Cancer Cells by Regulating Cytokine Production

(2016) Chia-Chien Hsieh et al.   PLoS One

Aspirin in the Treatment of Cancer: Reductions in Metastatic Spread and in Mortality: A Systematic Review and Meta-Analyses of Published Studies

(2016) Peter C. Elwood et al.   PLoS One

Metformin attenuated the inflammation after renal ischemia/reperfusion and suppressed apoptosis of renal tubular epithelial cell in rats

(2015) Zhi-shun Wang et al.   Acta Cirurgica Brasileira

DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells

(2015) Akio Obara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lifetime use of nonsteroidal anti-inflammatory drugs and breast cancer risk: results from a prospective study of women with a sister with breast cancer

(2015) Sangmi Kim et al.   BMC CANCER

Increased COX-2 expression in epithelial and stromal cells of high mammographic density tissues and in a xenograft model of mammographic density

(2015) G. L. Chew et al.   BREAST CANCER RESEARCH AND TREATMENT

Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells

(2015) Zheng Wang et al.   CANCER LETTERS

Metformin affects the features of a human hepatocellular cell line (HepG2) by regulating macrophage polarization in a co-culture microenviroment

(2015) Miaojiao Chen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer

(2015) CONG FAN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition

(2015) Gargi Maity et al.   LABORATORY INVESTIGATION

Lipoxins exert antiangiogenic and anti-inflammatory effects on Kaposi's sarcoma cells

(2015) Alexandru Marginean et al.   Translational Research

Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro

(2015) Xu Chen et al.   TUMOR BIOLOGY

Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity

(2014) Yuzhong Duan et al.   BMB Reports

Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4and its receptor

(2014) T Gobbetti et al.   BRITISH JOURNAL OF PHARMACOLOGY

The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

(2014) Stefania Orecchioni et al.   INTERNATIONAL JOURNAL OF CANCER

Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel-7402/5-fluorouracil cells

(2014) SUNBIN LING et al.   Molecular Medicine Reports

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study

(2012) Saroj Niraula et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

(2011) Irina N. Alimova et al.   CELL CYCLE

Radiation resistance, invasiveness and metastasis are inflammatory events that could be suppressed by lipoxin A4

(2011) Undurti N. Das   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Lipoxin and Aspirin-Triggered Lipoxins

(2011) Mario Romano   TheScientificWorldJOURNAL

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice

(2009) Fabrício A. Pamplona et al.   NEUROSCIENCE LETTERS