Journal
GENETICS AND MOLECULAR BIOLOGY
Volume 38, Issue 1, Pages 42-47Publisher
SOC BRASIL GENETICA
DOI: 10.1590/S1415-475738120140179
Keywords
MTHFR; MTR; MTRR; polymorphism; infertility
Funding
- National Science Centre grant [UMO-2011/01/B/NZ5/04235]
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Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.
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