期刊
GENETICS AND MOLECULAR BIOLOGY
卷 38, 期 1, 页码 42-47出版社
SOC BRASIL GENETICA
DOI: 10.1590/S1415-475738120140179
关键词
MTHFR; MTR; MTRR; polymorphism; infertility
资金
- National Science Centre grant [UMO-2011/01/B/NZ5/04235]
Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.
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