Article
Infectious Diseases
Yi Hu, Xubin Zheng, Lina Davies Forsman, Zhu Ning, Cheng Chen, Yazhou Gao, Zhengdong Zhang, Wei Lu, Jim Werngren, Judith Bruchfeld, Sven Hoffner, Biao Xu
Summary: Through whole-genome sequencing of MDR-TB patients, the study found that additional second-line drug resistance during MDR-TB treatment was mainly caused by exogenous reinfection, highlighting the need for enhanced infection control in healthcare facilities and repeated drug susceptibility testing throughout the treatment.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Liang Fu, Xilin Zhang, Juan Xiong, Feng Sun, Taoping Weng, Yang Li, Peize Zhang, Hui Li, Qianting Yang, Yi Cai, Hancheng Liang, Qiuqi Chen, Zhaoqing Wang, Lei Liu, Xinchun Chen, Wenhong Zhang, Guofang Deng
Summary: The study evaluated the safety and efficacy of three 9-month, all-oral, 5-drug regimens in the treatment of patients with multidrug-resistant tuberculosis (MDR-TB) and pre-extensive drug-resistant tuberculosis (pre-XDR-TB). The results showed that the primary outcome of these regimens was satisfactory in the majority of patients, with manageable and reversible adverse events.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Hongjo Choi, Jeongha Mok, Young Ae Kang, Dawoon Jeong, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Doosoo Jeon
Summary: A retrospective evaluation of MDR/RR tuberculosis treatment outcomes in Korea from 2011 to 2017 showed an improvement in treatment success rate. However, increasing deaths during treatment pose a new challenge for MDR-TB control. Special attention is needed for vulnerable populations such as the elderly, patients with comorbidities, and those with low household incomes.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Carly A. Rodriguez, Sara Lodi, C. Robert Horsburgh, Mathieu Bastard, Cathy Hewison, Helena Huerga, Munira Khan, Palwasha Y. Khan, Uzma Khan, Lawrence Oyewusi, Shrivani Padayachee, Carole D. Mitnick, Molly F. Franke
Summary: Extending the baseline culture interval past treatment initiation may introduce selection bias. The proportion of patients missing a pre-treatment culture and the number of deaths and losses to follow up during the post-treatment allowable interval should be clearly enumerated.
Article
Infectious Diseases
Yuhong Liu, Jingtao Gao, Jian Du, Wei Shu, Lu Wang, Yufeng Wang, Zhongtan Xue, Liang Li, Shaofa Xu, Yu Pang
Summary: This study aimed to investigate the prevalence of CFZ resistance in MDR-TB patients in China and track changes in CFZ susceptibility and molecular mechanism after exposure to BDQ and/or CFZ. The results showed a high rate of CFZ resistance among MDR-TB patients in China, and patients treated with BDQ-containing regimens achieved similar culture conversion rates regardless of baseline CFZ susceptibility. Acquired CFZ resistance was observed in some patients during treatment, even in those not receiving CFZ.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Editorial Material
Immunology
Sonya Krishnan, Richard E. Chaisson
Summary: In the global control of tuberculosis, providing tuberculosis-preventive therapy (TPT) to vulnerable populations is crucial. Shorter-course TPT regimens are highly effective and improve completion rates. Despite the inclusion of one month of rifapentine and isoniazid in global guidelines, current US TPT guidelines do not recommend this regimen, but they should.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Martha L. van der Walt, Karen Shean, Piet Becker, Karen H. Keddy, Joey Lancaster
Summary: The study compared treatment outcomes among MDR-TB patients receiving ethambutol, cycloserine, or terizidone as part of a standardized regimen. Results showed higher success rates and lower default rates in patients receiving cycloserine and terizidone, but higher culture conversion rates in those receiving cycloserine. Further investigation is needed to elucidate the differences observed between cycloserine and terizidone.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Infectious Diseases
Anna Starshinova, Irina Dovgalyk, Ekaterina Belyaeva, Anzhela Glushkova, Nikolay Osipov, Dmitry Kudlay
Summary: The use of bedaquiline in the treatment of multidrug- and extensive drug-resistant tuberculosis is of great relevance. The study showed that bedaquiline treatment achieved high conversion and recovery rates, with low rates of treatment interruption.
Article
Immunology
Tasnim Hasan, Ellie Medcalf, Bern-Thomas Nyang'wa, Erica Egizi, Catherine Berry, Matthew Dodd, Salah Foraida, Medea Gegia, Mengchun Li, Fuad Mirzayev, Hannah Morgan, Ilaria Motta, Linh Nguyen, Samuel Schumacher, Tim Schlub, Greg Fox
Summary: By reviewing and meta-analyzing clinical trial data, it was found that BPaL-containing regimens with a daily dose of 600 mg linezolid showed good tolerability, which may improve the tolerability of treatment for MDR/RR-TB.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Wasan Katip, Suriyon Uitrakul, Peninnah Oberdorfer
Summary: The study found that cancer patients who received a long course of colistin therapy had better clinical and microbiological responses, lower 30-day mortality, and similar nephrotoxicity compared to those who received a short course of treatment.
Article
Environmental Sciences
Erjia Ge, Jianhui Gao, Zhoupeng Ren, Xin Liu, Ming Luo, Jieming Zhong, Fangrong Fei, Bin Chen, Xiaomeng Wang, Xiaolin Wei, Ying Peng
Summary: The study found that higher levels of greenness near residential areas were associated with lower all-cause mortality among patients undergoing multidrug-resistant tuberculosis treatment in areas with lower nighttime light. This association was particularly strong for female patients, younger patients (<60 years old), those living in urban areas, or with high exposure to PM2.5 particles.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Infectious Diseases
Mohammed Hasen Bedaso, Falaho Sani Kalil
Summary: The study aimed to describe the magnitude, trends, and geographical distribution of drug-resistant TB in Bale Zone during the study period. Findings showed a decrease in the prevalence of drug-resistant TB, with RR TB being the most prevalent type among cases during the study period.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Teshome Belachew, Seid Yaheya, Nehemia Tilahun, Eshet Gebrie, Rim Seid, Tilahun Nega, Sirak Biset
Summary: This study investigates the proportions and predictors of treatment outcomes among MDR/RR-TB patients and finds that nearly 23% of patients have unsuccessful treatment outcomes, with older age being significantly associated with treatment failure. It is recommended to strengthen combined treatment adherence interventions and evaluate treatment regimens and administration options to improve outcomes.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, General & Internal
Berhane Megerssa Ereso, Mette Sagbakken, Christoph Gradmann, Solomon Abebe Yimer
Summary: Patients who chose community-based DOTS had a higher cure rate and lower risk of death and treatment failure compared to those who chose facility-based DOTS. Additionally, community-based DOTS resulted in a lower likelihood of positive sputum smear results compared to facility-based DOTS at the end of treatment.
Article
Infectious Diseases
Marwa Bachir, Lorenzo Guglielmetti, Simone Tunesi, Typhaine Billard-Pomares, Sheila Chiesi, Jeremy Jaffre, Hugo Langris, Valerie Pourcher, Frederic Schramm, Nadine Lemaitre, Jerome Robert
Summary: This study assessed the impact of rapid diagnostic tests on the treatment of HR-TB in France and found that early implementation of molecular detection can shorten the time to adequate treatment.
JOURNAL OF INFECTION
(2022)
Article
Virology
Laura Manuto, Marco Grazioli, Andrea Spitaleri, Paolo Fontana, Luca Bianco, Luigi Bertolotti, Martina Bado, Giorgia Mazzotti, Federico Bianca, Francesco Onelia, Giovanni Lorenzin, Fabio Simeoni, Dejan Lazarevic, Elisa Franchin, Claudia Del Vecchio, Ilaria Dorigatti, Giovanni Tonon, Daniela Maria Cirillo, Enrico Lavezzo, Andrea Crisanti, Stefano Toppo
Summary: This study investigates the COVID-19 outbreak in a small Italian town and reveals the unique ancestor haplotype of the virus, as well as its evolution within and across households. It provides evidence that novel viral haplotypes can naturally arise within a short time period, regardless of symptom severity or immune system deficiencies. The study also shows that the lockdown measures effectively controlled viral spread and the emergence of new variants.
Review
Microbiology
Jan Heyckendorf, Sophia B. Georghiou, Nicole Frahm, Norbert Heinrich, Irina Kontsevaya, Maja Reimann, David Holtzman, Marjorie Imperial, Daniela M. Cirillo, Stephen H. Gillespie, Morten Ruhwald
Summary: Despite advancements in diagnostics, drugs, and regimens, tuberculosis remains a major global health threat. The current methods for monitoring TB treatment and determining treatment success have limitations. However, molecular technologies and assays show promise as suitable alternatives, which can potentially revolutionize TB therapy monitoring and expedite drug development.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Article
Respiratory System
Philip W. Fowler, Ivan Barilar, Simone Battaglia, Emanuele Borroni, Angela Pires Brandao, Alice Brankin, Andrea Maurizio Cabibbe, Joshua Carter, Daniela Maria Cirillo, Pauline Claxton, David A. Clifton, Ted Cohen, Jorge Coronel, Derrick W. Crook, Viola Dreyer, Sarah G. Earle, Vincent Escuyer, Lucilaine Ferrazoli, George Fu Gao, Jennifer Gardy, Saheer Gharbia, Kelen Teixeira Ghisi, Arash Ghodousi, Ana Luiza Gibertoni Cruz, Louis Grandjean, Clara Grazian, Ramona Groenheit, Jennifer L. Guthrie, Wencong He, Harald Hoffmann, Sarah J. Hoosdally, Martin Hunt, Zamin Iqbal, Nazir Ahmed Ismail, Lisa Jarrett, Lavania Joseph, Ruwen Jou, Priti Kambli, Rukhsar Khot, Jeff Knaggs, Anastasia Koch, Donna Kohlerschmidt, Samaneh Kouchaki, Alexander S. Lachapelle, Ajit Lalvani, Simon Grandjean Lapierre, Ian F. Laurenson, Brice Letcher, Wan-Hsuan Lin, Chunfa Liu, Dongxin Liu, Kerri M. Malone, Ayan Mandal, Mikael Mansjo, Daniela Matias, Graeme Meintjes, Flavia de Freitas Mendes, Matthias Merker, Marina Mihalic, James Millard, Paolo Miotto, Nerges Mistry, David Moore, Kimberlee A. Musser, Dumisani Ngcamu, Hoang Ngoc Nhung, Stefan Niemann, Kayzad Soli Nilgiriwala, Camus Nimmo, Nana Okozi, Rosangela Siqueira Oliveira, Shaheed Vally Omar, Nicholas Paton, Timothy E. A. Peto, Juliana Maira Watanabe Pinhata, Sara Plesnik, Zully M. Puyen, Marie Sylvianne Rabodoarivelo, Niaina Rakotosamimanana, Paola M. Rancoita, Priti Rathod, Esther Robinson, Gillian Rodger, Camilla Rodrigues, Timothy C. Rodwell, Aysha Roohi, David Santos-Lazaro, Sanchi Shah, Thomas Andreas Kohl, Grace Smith, Walter Solano, Andrea Spitaleri, Philip Supply, Utkarsha Surve, Sabira Tahseen, Nguyen Thuy Thuong, Guy Thwaites, Katharina Todt, Alberto Trovato, Christian Utpatel, Annelies Van Rie, Srinivasan Vijay, Timothy M. Walker, A. Sarah Walker, Robin Warren, Jim Werngren, Maria Wijkander, Robert J. Wilkinson, Daniel J. Wilson, Penelope Wintringer, Yu-Xin Xiao, Yang, Zhao Yanlin, Shen-Yuan Yao, Baoli Zhu
Summary: This study determines the epidemiological cut-off values (ECOFF/ECVs) for 13 anti-tuberculosis compounds, which will facilitate the measurement of drug susceptibility in Mycobacterium tuberculosis. These findings can contribute to personalized tuberculosis treatment.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Mahamadou Bassirou Souleymane, Tom Decroo, Saidou Mamadou, Alphazazi Soumana, Ibrahim Mamane Lawan, Assiatou Gagara-Issoufou, Eric Adehossi, Nimer Ortuno-Gutierrez, Lutgarde Lynen, Leen Rigouts, Bouke Catherine de Jong, Armand Van Deun, Alberto Piubello
Summary: This study reports the definitive outcomes of retreatment for rifampicin-resistant tuberculosis (RR-TB). A cascade approach using a bedaquiline-based regimen showed successful results in patients who experienced failure or relapse after a fluoroquinolone-based treatment.
INTERNATIONAL HEALTH
(2023)
Article
Genetics & Heredity
Enrico Lavezzo, Monia Pacenti, Laura Manuto, Caterina Boldrin, Margherita Cattai, Marco Grazioli, Federico Bianca, Margherita Sartori, Federico Caldart, Gioele Castelli, Michele Nicoletti, Eleonora Nieddu, Elisa Salvadoretti, Beatrice Labella, Ludovico Fava, Maria Cristina Vanuzzo, Vittoria Lisi, Maria Antonello, Carmela Ileana Grimaldi, Chiara Zulian, Claudia Del Vecchio, Mario Plebani, Andrea Padoan, Daniela Maria Cirillo, Alessandra R. Brazzale, Giovanni Tonon, Stefano Toppo, Ilaria Dorigatti, Andrea Crisanti
Summary: The study investigated the long-term antibody persistence in previously infected individuals and the extent of antibody-mediated protection against different SARS-CoV-2 variants in vaccinated and unvaccinated subjects.
Article
Biochemistry & Molecular Biology
Camilla Rodrigues, David Moore, Derrick W. Crook, Daniela M. Cirillo, Philip W. Fowler, Zamin Iqbal, Nazir A. Ismail, Nerges Mistry, Stefan Niemann, Tim E. A. Peto, Guy Thwaites, A. Sarah Walker, Timothy MWalker, Daniel J. Wilson, Sarah G. Earle, Daniel J. Wilson, Clara Grazian, A. Sarah Walker, Martin Hunt, Jeff Knaggs, Zamin Iqbal
Summary: The emergence of drug-resistant tuberculosis is a global health concern. Whole-genome sequencing can uncover new resistance mechanisms. This study identified uncatalogued variants associated with minimum inhibitory concentration and improved our knowledge of antimicrobial resistance in M. tuberculosis.
Article
Infectious Diseases
Christelle Genevieve Jouego, Tinne Gils, Alberto Piubello, Vincent Mbassa, Albert Kuate, Annie Ngono, Edwige Belinga, Antoine Etoundi, Alphonse Tollo, Danielle Makondi, Emmanuel Andre, Palmer Masumbe, Lutgarde Lynen, Juergen Noeske, Tom Decroo
Summary: This study aimed to describe treatment outcomes and the frequency of acquired drug resistance in patients with rifampicin-resistant tuberculosis treated using a standard regimen in Cameroon. The study found that both the standard treatment regimen and modified treatment regimens resulted in excellent treatment outcomes.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Pharmacology & Pharmacy
Clara Sciorati, Rebecca De Lorenzo, Nicola I. Lore, Cristina Tresoldi, Daniela M. Cirillo, Fabio Ciceri, Angelo Corti, Angelo A. Manfredi, Patrizia Rovere-Querini
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Francesca Nicola, Daniela M. Cirillo, Nicola I. Lore
Summary: This article reviews the current murine models for M. abscessus lung infection and their application in studying new therapeutic approaches. The murine models can be used to validate new targets and drugs and study the combinatorial regimens and dosage and administration of existing antibiotics. Additionally, the murine models can be used to develop new therapeutic approaches to modulate the host immune response and limit immunopathological damage.
Article
Infectious Diseases
Kobto G. G. Koura, Olivia B. B. Mbitikon, Attannon A. A. Fiogbe, Abdoul R. R. Ouedraogo, Albert Kuate Kuate, Aboubacar S. S. Magassouba, Alphazazi Soumana, Georges Hermana, Barnabe Gning, Mohammed F. F. Dogo, Monicah Andefa, Gisele Badoum
Summary: The study aimed to implement contact investigation (CI) under national tuberculosis programmatic conditions and advocate for its scaling up. CI was conducted in 150 Basic Management Units across eight countries, evaluating target populations (children <5 years and persons living with HIV) through home and clinic visits. Contacts with active TB were treated while eligible individuals received TB preventive therapy. Data were collected quarterly using standardized forms, and meetings were held with partners to share preliminary results and advocate for scaling up. The scale-up for CI was effective in six out of the eight countries in 2022, indicating its feasibility within the National TB Programs of African countries.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Microbiology
Mehri Haeili, Samaneh Barmudeh, Maryam Omrani, Narges Zeinalzadeh, Hossein Samadi Kafil, Virginia Batignani, Arash Ghodousi, Daniela Maria Cirillo
Summary: This study investigated the incidence of carbapenem resistance among 104 clinical isolates of Escherichia coli and the genomic features of carbapenem resistant isolates. Four isolates were identified as carbapenem resistant E. coli and exhibited high susceptibility to colistin, nitrofurantoin, fosfomycin, and tigecycline. Molecular analysis revealed different sequence types and the presence of NDM carbapenemase gene in all carbapenem resistant isolates. Various amino acid substitutions were found in a colistin-carbapenem resistant isolate.
Article
Microbiology
Federico Di Marco, Andrea Spitaleri, Simone Battaglia, Virginia Batignani, Andrea Maurizio Cabibbe, Daniela Maria Cirillo
Summary: This study compared the performances of short-reads (SRS), long-reads (LRS), and hybrid-reads (HYBR) in various investigative tasks in Mycobacterium tuberculosis (MTB) genome analysis. The results showed that HYBR exhibited the best performance in genome coverage estimation and variant calling, and also had better assembly quality compared to SRS and LRS. Therefore, the use of HYBR technology can provide a comprehensive resolution of the MTB genome and achieve more accurate analysis results.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Sophia B. Georghiou, Margaretha de Vos, Kavindhran Velen, Paolo Miotto, Rebecca E. Colman, Daniela Maria Cirillo, Nazir Ismail, Timothy C. Rodwell, Anita Suresh, Morten Ruhwald
Summary: Diagnostic development must be conducted alongside drug development to ensure the effectiveness of tuberculosis treatment. The lack of rapid molecular diagnostic options for certain drugs compromises the current treatment regimens. This article identifies the diagnostic gaps and proposes design priorities for next generation molecular assays to support appropriate treatment selection based on drug resistance and achieve End TB targets.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Infectious Diseases
Mahamadou Bassirou Souleymane, Sani Kadri, Alberto Piubello, Achilleas Tsoumanis, Alphazazi Soumana, Hamidou Issa, Abdoulaziz Kabirou Amoussa, Armand Van Deun, Lutgarde Lynen, Bouke Catherine de Jong, Tom Decroo
Summary: The TRIDORE study aims to compare the safety of a high-dose regimen (6R3H3ZE) with a normal-dose regimen (6RHZE) in previously treated patients with R-susceptible recurrent tuberculosis. The results showed that the use of 6R3H3ZE regimen led to significantly more drug-related severe adverse events.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Michal Bar-Oz, Maria Carla Martini, Maria Natalia Alonso, Michal Meir, Nicola Ivan Lore, Paolo Miotto, Camilla Riva, Shiva K. Angala, Junpei Xiao, Catherine S. Masiello, Maria-Anna Misiakou, Huaming Sun, Justin K. Moy, Mary Jackson, Helle Krogh Johansen, Daniela Maria Cirillo, Scarlet S. Shell, Daniel Barkan
Summary: This study reveals that the sRNA B11 controls gene expression and virulence-associated phenotypes in Mycobacterium abscessus. Deletion of B11 increased pro-inflammatory signaling, virulence, and antibiotic resistance. Clinical isolates with B11 mutations or reduced expression were also identified. This is the first report on the role of sRNA in M. abscessus.