The Type 3 Deiodinase: Epigenetic Control of Brain Thyroid Hormone Action and Neurological Function

Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis

(2018) Ildem Sanli et al.   Cell Reports

Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature

(2017) Frédéric Flamant et al.   ENDOCRINOLOGY

Deletion of the Thyroid Hormone–Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase

(2017) Lily Ng et al.   ENDOCRINOLOGY

Increased aggression and lack of maternal behavior in Dio3-deficient mice are associated with abnormalities in oxytocin and vasopressin systems

(2017) J. P. Stohn et al.   GENES BRAIN AND BEHAVIOR

Expression and imprinting of DIO3 and DIO3OS genes in Holstein cattle

(2017) Wenzhi Yang et al.   JOURNAL OF GENETICS

The ups and downs of the thyroxine pro-hormone hypothesis

(2017) Valerie Anne Galton   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin

(2017) E Tunc-Ozcan et al.   MOLECULAR PSYCHIATRY

Type 3 Deiodinase Role on Central Thyroid Hormone Action Affects the Leptin-Melanocortin System and Circadian Activity

(2016) Zhaofei Wu et al.   ENDOCRINOLOGY

Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice

(2016) Barbara M. L. C. Bocco et al.   ENDOCRINOLOGY

The Type 3 Deiodinase Is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis

(2016) M. Elena Martinez et al.   ENDOCRINOLOGY

Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14

(2016) Maria Elena Martinez et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

An imprinted long noncoding RNA located between genes Meg8 and Meg9 in the cattle Dlk1-Dio3 domain

(2016) Mingyue Zhang et al.   GENETICA

Methylation differences and expression profiles of the caprine DIO3 gene

(2016) H. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Thyroxine administration prevents matrilineal intergenerational consequences of in utero ethanol exposure in rats

(2016) Elif Tunc-Ozcan et al.   HORMONES AND BEHAVIOR

Deletion of the miR-379/miR-410 gene cluster at the imprintedDlk1-Dio3locus enhances anxiety-related behaviour

(2016) Virginie Marty et al.   HUMAN MOLECULAR GENETICS

Thyroid hormone regulated genes in cerebral cortex development

(2016) Juan Bernal   JOURNAL OF ENDOCRINOLOGY

Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction

(2016) Mary A M Cleaton et al.   NATURE GENETICS

Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism

(2016) J. Patrizia Stohn et al.   PSYCHONEUROENDOCRINOLOGY

Thyroid hormone signaling during early neurogenesis and its significance as a vulnerable window for endocrine disruption

(2015) Laetitia Préau et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A temporary compendium of thyroid hormone target genes in brain

(2015) F. Chatonnet et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Global Transcriptome Analysis of Primary Cerebrocortical Cells: Identification of Genes Regulated by Triiodothyronine in Specific Cell Types

(2015) Pilar Gil-Ibañez et al.   CEREBRAL CORTEX

Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines

(2015) Chu-Fan Mo et al.   Stem Cell Research & Therapy

Ascorbic acid improves pluripotency of human parthenogenetic embryonic stem cells through modifying imprinted gene expression in the Dlk1-Dio3 region

(2015) Yang Yu et al.   Stem Cell Research & Therapy

ICR Noncoding RNA Expression Controls Imprinting and DNA Replication at the Dlk1-Dio3 Domain

(2014) Satya K. Kota et al.   DEVELOPMENTAL CELL

Life Without the Iodothyronine Deiodinases

(2014) Valerie Anne Galton et al.   ENDOCRINOLOGY

Regulation and Function of Deiodinases During Decidualization in Female Mice

(2014) Wen-Bo Deng et al.   ENDOCRINOLOGY

Mammalian viviparity: a complex niche in the evolution of genomic imprinting

(2014) E B Keverne   HEREDITY

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis

(2014) Steffen Mayerl et al.   JOURNAL OF CLINICAL INVESTIGATION

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Genomic Imprinting Variations in the Mouse Type 3 Deiodinase Gene Between Tissues and Brain Regions

(2014) M. Elena Martinez et al.   MOLECULAR ENDOCRINOLOGY

Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure

(2014) S L Hollins et al.   Translational Psychiatry

Thyroid Hormone Signaling and Adult Neurogenesis in Mammals

(2014) Sylvie Remaud et al.   Frontiers in Endocrinology

Perturbations to the IGF1 growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting

(2013) M. Charalambous et al.   Acta Physiologica

Low-Dose Thyroxine Attenuates Autism-Associated Adverse Effects of Fetal Alcohol in Male Offspring's Social Behavior and Hippocampal Gene Expression

(2013) Elif Tunc-Ozcan et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Thyroid hormone signaling

(2013) Douglas Forrest et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cardiac Expression of Deiodinase type 3 (Dio3) Following Myocardial Infarction Is Associated With the Induction of a Pluripotency microRNA Signature from the Dlk1-Dio3 Genomic Region

(2013) Rob Janssen et al.   ENDOCRINOLOGY

Evolution of genomic imprinting as a coordinator of coadapted gene expression

(2013) J. B. Wolf   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic imprinting of the type 3 thyroid hormone deiodinase gene: Regulation and developmental implications

(2012) Marika Charalambous et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Function of thyroid hormone transporters in the central nervous system

(2012) Ulrich Schweizer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Thyroid hormone receptors: The challenge of elucidating isotype-specific functions and cell-specific response

(2012) Frédéric Flamant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The pathophysiological consequences of thyroid hormone transporter deficiencies: Insights from mouse models

(2012) Heike Heuer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Imprinted Gene Dosage Is Critical for the Transition to Independent Life

(2012) Marika Charalambous et al.   Cell Metabolism

Critical Role of Types 2 and 3 Deiodinases in the Negative Regulation of Gene Expression by T3in the Mouse Cerebral Cortex

(2012) Arturo Hernandez et al.   ENDOCRINOLOGY

Cerebellar Abnormalities in Mice Lacking Type 3 Deiodinase and Partial Reversal of Phenotype by Deletion of Thyroid Hormone Receptor α1

(2012) Robin P. Peeters et al.   ENDOCRINOLOGY

Paternal uniparental disomy 14 and related disorders

(2012) Masayo Kagami et al.   Epigenetics

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all–iPS cell mice from terminally differentiated B cells

(2012) Matthias Stadtfeld et al.   NATURE GENETICS

Imprinting and expression of Dio3os mirrors Dio3 in rat

(2012) William H. Dietz et al.   Frontiers in Genetics

Strain-specific vulnerability to alcohol exposure in utero via hippocampal parent-of-origin expression of deiodinase-III

(2011) Laura J. Sittig et al.   FASEB JOURNAL

Expression of DLK1 and MEG3 genes in porcine tissues during postnatal development

(2011) Maria Oczkowicz et al.   GENETICS AND MOLECULAR BIOLOGY

Imprinting analysis of porcine DIO3 gene in two fetal stages and association analysis with carcass and meat quality traits

(2011) Mu Qiao et al.   MOLECULAR BIOLOGY REPORTS

Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells

(2011) E Gardiner et al.   MOLECULAR PSYCHIATRY

Parent-of-origin allelic contributions to deiodinase-3 expression elicit localized hyperthyroid milieu in the hippocampus

(2011) L J Sittig et al.   MOLECULAR PSYCHIATRY

Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis

(2011) Sacri R. Ferrón et al.   NATURE

Genomic imprinting: the emergence of an epigenetic paradigm

(2011) Anne C. Ferguson-Smith   NATURE REVIEWS GENETICS

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

(2011) Andreas Meyer-Lindenberg et al.   NATURE REVIEWS NEUROSCIENCE

Candidate Placental Biomarkers for Intrauterine Alcohol Exposure

(2010) Pradeep K. Shukla et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

How Demography, Life History, and Kinship Shape the Evolution of Genomic Imprinting

(2010) Jeremy Van Cleve et al.   AMERICAN NATURALIST

Retrotransposon silencing by DNA methylation contributed to the evolution of placentation and genomic imprinting in mammals

(2010) Tomoko Kaneko-Ishino et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Thyroid Hormone-Regulated Mouse Cerebral Cortex Genes Are Differentially Dependent on the Source of the Hormone: A Study in Monocarboxylate Transporter-8- and Deiodinase-2-Deficient Mice

(2010) Beatriz Morte et al.   ENDOCRINOLOGY

Type 3 Deiodinase Deficiency Causes Spatial and Temporal Alterations in Brain T3Signaling that Are Dissociated from Serum Thyroid Hormone Levels

(2010) Arturo Hernandez et al.   ENDOCRINOLOGY

Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 14

(2010) Tsutomu Ogata et al.   Epigenetics

Paracrine signaling by glial cell–derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells

(2010) Beatriz C.G. Freitas et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 3 Deiodinase, a Thyroid-Hormone-Inactivating Enzyme, Controls Survival and Maturation of Cone Photoreceptors

(2010) L. Ng et al.   JOURNAL OF NEUROSCIENCE

Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns

(2010) W. Edward Visser et al.   MOLECULAR ENDOCRINOLOGY

Pathophysiological Importance of Thyroid Hormone Transporters

(2009) Heike Heuer et al.   ENDOCRINOLOGY

The Begain gene marks the centromeric boundary of the imprinted region on mouse chromosome 12

(2009) Sascha Tierling et al.   MAMMALIAN GENOME

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1

(2009) John P. Hagan et al.   PLoS One

Prenatal thyroxine treatment disparately affects peripheral and amygdala thyroid hormone levels

(2009) Pradeep K. Shukla et al.   PSYCHONEUROENDOCRINOLOGY

A Protective Role for Type 3 Deiodinase, a Thyroid Hormone-Inactivating Enzyme, in Cochlear Development and Auditory Function

(2008) Lily Ng et al.   ENDOCRINOLOGY

Epimutation (hypomethylation) affecting the chromosome 14q32.2 imprinted region in a girl with upd(14)mat-like phenotype

(2008) Kana Hosoki et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Clinical features of maternal uniparental disomy 14 in patients with an epimutation and a deletion of the imprintedDLK1/GTL2gene cluster

(2008) Karin Buiting et al.   HUMAN MUTATION

Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes

(2008) Masayo Kagami et al.   NATURE GENETICS

Genomic imprinting at the mammalian Dlk1-Dio3 domain

(2008) Simao Teixeira da Rocha et al.   TRENDS IN GENETICS

The Evolution of the DLK1-DIO3 Imprinted Domain in Mammals

(2008) Carol A Edwards et al.   PLOS BIOLOGY