The lasting impact of early-life adversity on individuals and their descendants: potential mechanisms and hope for intervention

Altered stress responses in children exposed to early adversity: A systematic review of salivary cortisol studies

(2016) Ann Louise Hunter et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience

(2015) Ali B. Rodgers et al.   BIOLOGICAL PSYCHIATRY

Gut microbiome composition is associated with temperament during early childhood

(2015) Lisa M. Christian et al.   BRAIN BEHAVIOR AND IMMUNITY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Efficacy of Atomoxetine for Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with a History of Child Abuse

(2015) Atsunori Sugimoto et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

The intergenerational impact of war: longitudinal relationships between caregiver and child mental health in postconflict Sierra Leone

(2015) Theresa S. Betancourt et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Clinical Predictors of Response to Cognitive-Behavioral Therapy in Pediatric Anxiety Disorders: The Genes for Treatment (GxT) Study

(2015) Jennifer L. Hudson et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Why Microbiome Treatments Could Pay Off Soon

(2015) Rob Knight   NATURE

Epigenetic and transgenerational reprogramming of brain development

(2015) Tracy L. Bale   NATURE REVIEWS NEUROSCIENCE

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health

(2015) Olena Babenko et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

An international approach to research on brain development

(2015) Charles A. Nelson   TRENDS IN COGNITIVE SCIENCES

Nongenetic inheritance and transgenerational epigenetics

(2015) Moshe Szyf   TRENDS IN MOLECULAR MEDICINE

Epigenetic mechanisms underlying learning and the inheritance of learned behaviors

(2015) Brian G. Dias et al.   TRENDS IN NEUROSCIENCES

Microbiota and host determinants of behavioural phenotype in maternally separated mice

(2015) G. De Palma et al.   Nature Communications

The Intergenerational Effect of War

(2015) Theresa S. Betancourt   JAMA Psychiatry

Effects of prenatal and postnatal depression and maternal stroking, at the glucocorticoid receptor gene

(2015) C Murgatroyd et al.   Translational Psychiatry

Intervention programs for children whose parents have a mental illness: a review

(2015) Andrea E Reupert et al.   MEDICAL JOURNAL OF AUSTRALIA

Influences of Maternal and Paternal PTSD on Epigenetic Regulation of the Glucocorticoid Receptor Gene in Holocaust Survivor Offspring

(2014) Rachel Yehuda et al.   AMERICAN JOURNAL OF PSYCHIATRY

The NIMH Research Domain Criteria (RDoC) Project: Precision Medicine for Psychiatry

(2014) Thomas R. Insel   AMERICAN JOURNAL OF PSYCHIATRY

Early emergence of adult-like fear renewal in the developing rat after chronic corticosterone treatment of the dam or the pups.

(2014) Bridget L. Callaghan et al.   BEHAVIORAL NEUROSCIENCE

Psychological functioning 1 year after a brief intervention using micronutrients to treat stress and anxiety related to the 2011 Christchurch earthquakes: a naturalistic follow-up

(2014) Julia J. Rucklidge et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Models of Stress in Nonhuman Primates and Their Relevance for Human Psychopathology and Endocrine Dysfunction

(2014) J. S. Meyer et al.   ILAR JOURNAL

Epigenetic Signaling in Psychiatric Disorders

(2014) Catherine J. Peña et al.   JOURNAL OF MOLECULAR BIOLOGY

The Consequences of Early-Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations

(2014) S. Maccari et al.   JOURNAL OF NEUROENDOCRINOLOGY

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Early-Life Experience, Epigenetics and the Developing Brain

(2014) Marija Kundakovic et al.   NEUROPSYCHOPHARMACOLOGY

Adolescent mental health--Opportunity and obligation

(2014) F. S. Lee et al.   SCIENCE

Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene

(2014) Jeremy D. Coplan et al.   Frontiers in Behavioral Neuroscience

Modulation of early stress-induced neurobiological changes: a review of behavioural and pharmacological interventions in animal models

(2014) E L Harrison et al.   Translational Psychiatry

Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: systematic review of contributing factors

(2014) Nikolaos P. Daskalakis et al.   Frontiers in Neuroscience

Effects of early life adverse experiences on the brain: implications from maternal separation models in rodents

(2014) Mayumi Nishi et al.   Frontiers in Neuroscience

The neurobiological correlates of childhood adversity and implications for treatment

(2013) A. R. Tyrka et al.   ACTA PSYCHIATRICA SCANDINAVICA

Parental styles in the intergenerational transmission of trauma stemming from the Khmer Rouge regime in Cambodia.

(2013) Nigel P. Field et al.   AMERICAN JOURNAL OF ORTHOPSYCHIATRY

Transgenerational Effects of Variable Foraging Demand Stress in Female Bonnet Macaques

(2013) ERIN L. KINNALLY et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Acute early-life stress results in premature emergence of adult-like fear retention and extinction relapse in infant rats.

(2013) Caitlin S. M. Cowan et al.   BEHAVIORAL NEUROSCIENCE

Psychobiotics: A Novel Class of Psychotropic

(2013) Timothy G. Dinan et al.   BIOLOGICAL PSYCHIATRY

Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine

(2013) MVE Veenendaal et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Adult mental health disorders and their age at onset

(2013) P. B. Jones   BRITISH JOURNAL OF PSYCHIATRY

You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring

(2013) Kimberly Vanhees et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CHILDHOOD MALTREATMENT AND RESPONSE TO COGNITIVE BEHAVIORAL THERAPY AMONG INDIVIDUALS WITH SOCIAL ANXIETY DISORDER

(2013) Laura C. Bruce et al.   DEPRESSION AND ANXIETY

Consumption of Fermented Milk Product With Probiotic Modulates Brain Activity

(2013) Kirsten Tillisch et al.   GASTROENTEROLOGY

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

DNA methylation and childhood maltreatment: From animal models to human studies

(2013) P.-E. Lutz et al.   NEUROSCIENCE

Early developmental emergence of human amygdala-prefrontal connectivity after maternal deprivation

(2013) D. G. Gee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics

(2013) Paul J. Lucassen et al.   TRENDS IN NEUROSCIENCES

Posttraumatic Stress Disorder Across Two Generations: Concordance and Mechanisms in a Population-Based Sample

(2012) Andrea L. Roberts et al.   BIOLOGICAL PSYCHIATRY

Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients

(2012) Maaike H Nauta et al.   BMC Psychiatry

The Role of Life Events and HPA Axis in Anxiety Disorders: A Review

(2012) Carlo Faravelli et al.   CURRENT PHARMACEUTICAL DESIGN

Methylation changes atNR3C1in newborns associate with maternal prenatal stress exposure and newborn birth weight

(2012) Connie Mulligan et al.   Epigenetics

Neonatal isolation decreases cued fear conditioning and frontal cortical histone 3 lysine 9 methylation in adult female rats

(2012) Gour-Shenq Kao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses

(2012) Julia J Rucklidge et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults

(2012) Audrey R. Tyrka et al.   PLoS One

Paternal social enrichment effects on maternal behavior and offspring growth

(2012) R. Mashoodh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus

(2012) M. Suderman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of adverse rearing environments on persistent memories in young rats: removing the brakes on infant fear memories

(2012) B L Callaghan et al.   Translational Psychiatry

Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression: A Meta-Analysis

(2011) Valentina Nanni et al.   AMERICAN JOURNAL OF PSYCHIATRY

Maternal separation results in early emergence of adult-like fear and extinction learning in infant rats.

(2011) Bridget L. Callaghan et al.   BEHAVIORAL NEUROSCIENCE

Adverse Rearing Environments and Neural Development in Children: The Development of Frontal Electroencephalogram Asymmetry

(2011) Katie A. McLaughlin et al.   BIOLOGICAL PSYCHIATRY

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Effect of Preventive Interventions in Mentally Ill Parents on the Mental Health of the Offspring: Systematic Review and Meta-Analysis

(2011) Eliane Siegenthaler et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heritability and genetic correlation of hair cortisol in vervet monkeys in low and higher stress environments

(2011) Lynn A. Fairbanks et al.   PSYCHONEUROENDOCRINOLOGY

Epigenome targeting by probiotic metabolites

(2011) Paul V Licciardi et al.   Gut Pathogens

Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma

(2011) N Perroud et al.   Translational Psychiatry

Childhood Adversities and Adult Psychiatric Disorders in the National Comorbidity Survey Replication I

(2010) Jennifer Greif Green et al.   ARCHIVES OF GENERAL PSYCHIATRY

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

(2010) Michaël Messaoudi et al.   BRITISH JOURNAL OF NUTRITION

Maternal Exposure to the Dutch Famine Before Conception and During Pregnancy

(2010) Aryeh D. Stein et al.   EPIDEMIOLOGY

Epigenetics and the origins of paternal effects

(2010) James P. Curley et al.   HORMONES AND BEHAVIOR

Epigenetic marking of the BDNF gene by early-life adverse experiences

(2010) Tania L. Roth et al.   HORMONES AND BEHAVIOR

The Clinical-Basic Interface in Defining Pathogenesis in Disorders of Neurodevelopmental Origin

(2010) Barbara L. Thompson et al.   NEURON

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

(2010) L. Desbonnet et al.   NEUROSCIENCE

Critical Age Windows for Neurodevelopmental Psychiatric Disorders: Evidence from Animal Models

(2010) Eva M. Marco et al.   NEUROTOXICITY RESEARCH

Methylation at 5HTT Mediates the Impact of Child Sex Abuse on Womenʼs Antisocial Behavior: An Examination of the Iowa Adoptee Sample

(2010) Steven R. H. Beach et al.   PSYCHOSOMATIC MEDICINE

Is there intergenerational transmission of trauma? The case of combat veterans' children.

(2009) Rachel Dekel et al.   AMERICAN JOURNAL OF ORTHOPSYCHIATRY

Long-term effectiveness of a parenting intervention for children at risk of developing conduct disorder

(2009) Tracey Bywater et al.   BRITISH JOURNAL OF PSYCHIATRY

Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques

(2009) E. L. Kinnally et al.   GENES BRAIN AND BEHAVIOR

Early-Life Stress Disrupts Attachment Learning: The Role of Amygdala Corticosterone, Locus Ceruleus Corticotropin Releasing Hormone, and Olfactory Bulb Norepinephrine

(2009) S. Moriceau et al.   JOURNAL OF NEUROSCIENCE

Childhood separation experience predicts HPA axis hormonal responses in late adulthood: A natural experiment of World War II

(2009) Anu-Katriina Pesonen et al.   PSYCHONEUROENDOCRINOLOGY

A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome

(2009) A Venket Rao et al.   Gut Pathogens

Effects of Parent Skills Training with Behavioral Couples Therapy for alcoholism on children: A randomized clinical pilot trial

(2008) Wendy K. Lam et al.   ADDICTIVE BEHAVIORS

Maternal, not paternal, PTSD is related to increased risk for PTSD in offspring of Holocaust survivors

(2008) Rachel Yehuda et al.   JOURNAL OF PSYCHIATRIC RESEARCH