Regulation of T-Cell Signaling by Post-Translational Modifications in Autoimmune Disease

Acetylation regulates the MKK4-JNK pathway in T cell receptor signaling

(2018) Yukihide Matsui et al.   IMMUNOLOGY LETTERS

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model

(2017) Misato Ito et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

(2017) Peter C. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Baricitinib, Methotrexate, or Combination in Patients With Rheumatoid Arthritis and No or Limited Prior Disease-Modifying Antirheumatic Drug Treatment

(2017) Roy Fleischmann et al.   Arthritis & Rheumatology

Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study

(2016) Maxime Dougados et al.   ANNALS OF THE RHEUMATIC DISEASES

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Lymph node - an organ for T-cell activation and pathogen defense

(2016) Georg Gasteiger et al.   IMMUNOLOGICAL REVIEWS

Acetylation Modulates IL-2 Receptor Signaling in T Cells

(2016) Taku Kuwabara et al.   JOURNAL OF IMMUNOLOGY

Baricitinib in Patients with Refractory Rheumatoid Arthritis

(2016) Mark C. Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis

(2013) Joel Kremer et al.   ANNALS OF INTERNAL MEDICINE

Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study

(2013) Désirée van der Heijde et al.   ARTHRITIS AND RHEUMATISM

Structure and mechanism of non-histone protein acetyltransferase enzymes

(2013) David R. Friedmann et al.   FEBS Journal

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial

(2013) Gerd R Burmester et al.   LANCET

Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation

(2012) Hideyuki Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats

(2012) Kazuhiko Haruta et al.   INFLAMMATION RESEARCH

SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation

(2012) Thang Van Nguyen et al.   MOLECULAR CELL

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis

(2012) Ronald F. van Vollenhoven et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6

(2011) Wenda Gao et al.   CELL CYCLE

LIF in the regulation of T-cell fate and as a potential therapeutic

(2011) S M Metcalfe   GENES AND IMMUNITY

Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

(2011) Akiko Hashimoto-Tane et al.   IMMUNITY

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

(2011) Kamran Ghoreschi et al.   JOURNAL OF IMMUNOLOGY

Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

(2010) Patrick G. Hogan et al.   Annual Review of Immunology

CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment

(2010) Go Itoh et al.   EMBO JOURNAL

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

(2010) Mark E. Flanagan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of CD4+ T Lymphocyte Lineage Outcomes with Targeted, Nanoparticle-Mediated Cytokine Delivery

(2010) Jason Park et al.   MOLECULAR PHARMACEUTICS

MEC-17 is an α-tubulin acetyltransferase

(2010) Jyothi S. Akella et al.   NATURE

Acetylation modulates prolactin receptor dimerization

(2010) L. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CP-690550, a Janus Kinase Inhibitor, Suppresses CD4+ T-Cell–Mediated Acute Graft-Versus-Host Disease by Inhibiting the Interferon-γ Pathway

(2010) Hyung-Bae Park et al.   TRANSPLANTATION

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

The Cellular Context of T Cell Signaling

(2009) Michael L. Dustin   IMMUNITY

Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation

(2009) Jun O. Liu   IMMUNOLOGICAL REVIEWS

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

(2009) Douglas C. Palmer et al.   TRENDS IN IMMUNOLOGY

Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis

(2008) Sharon Veenbergen et al.   ARTHRITIS AND RHEUMATISM

Calcium signaling in lymphocytes

(2008) Masatsugu Oh-hora et al.   CURRENT OPINION IN IMMUNOLOGY

Crosstalk via the NF-κB signaling system

(2008) Soumen Basak et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

(2008) Brian T. Fife et al.   IMMUNOLOGICAL REVIEWS

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human Naturally Occurring and Adaptive Regulatory T cells Secrete High Levels of Leukaemia Inhibitory Factor upon Activation

(2008) M. Mahic et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

(2008) Anthony J Milici et al.   ARTHRITIS RESEARCH & THERAPY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology