Do Neuroendocrine Peptides and Their Receptors Qualify as Novel Therapeutic Targets in Osteoarthritis?

Osteoblast role in osteoarthritis pathogenesis

(2017) Nicola Maruotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons

(2017) Liisa Ailanen et al.   JOURNAL OF ENDOCRINOLOGY

Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease

(2017) Dulari Jayawardena et al.   MOLECULAR PHARMACEUTICS

Differently polarized macrophages affect the viability and growth of NSPCs by regulating the expression of PACAP

(2017) Min Liu et al.   NEUROPEPTIDES

Chondroprotective activity of N-acetyl phenylalanine glucosamine derivative on knee joint structure and inflammation in a murine model of osteoarthritis

(2017) F. Veronesi et al.   OSTEOARTHRITIS AND CARTILAGE

Neuropeptide Y enhances proliferation and prevents apoptosis in rat bone marrow stromal cells in association with activation of the Wnt/β-catenin pathway in vitro

(2017) Jianqun Wu et al.   Stem Cell Research

Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy

(2017) Song Peng et al.   Stem Cells International

In-Situ-Generated Vasoactive Intestinal Peptide Loaded Microspheres in Mussel-Inspired Polycaprolactone Nanosheets Creating Spatiotemporal Releasing Microenvironment to Promote Wound Healing and Angiogenesis

(2016) Yuzhen Wang et al.   ACS Applied Materials & Interfaces

α-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients

(2016) Markus Böhm et al.   BIOCHEMICAL PHARMACOLOGY

The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay

(2016) Ee-Cheng Khor et al.   BONE

Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3

(2016) Trinidad Montero-Melendez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Decreased Synovial Fluid α-Melanocyte-Stimulating-Hormone (α-MSH) Levels Reflect Disease Severity in Patients with Posttraumatic Ankle Osteoarthritis

(2016) Guangyu Liu et al.   Clinical Laboratory

Neuropeptide Y is an angiogenic factor in cardiovascular regeneration

(2016) Rabya Saraf et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Conjugated Alpha-Alumina nanoparticle with vasoactive intestinal peptide as a Nano-drug in treatment of allergic asthma in mice

(2016) Seyyed Shamsadin Athari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection

(2016) Mila F. M. Madeira et al.   FASEB JOURNAL

Trophoblast cells inhibit neutrophil extracellular trap formation and enhance apoptosis through vasoactive intestinal peptide-mediated pathways

(2016) Guillermina Calo et al.   HUMAN REPRODUCTION

VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts

(2016) Selene Pérez-García et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

VIP impairs acquisition of the macrophage proinflammatory polarization profile

(2016) Mar Carrión et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells

(2016) Xiao-chuan Gu et al.   NEUROPEPTIDES

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts

(2016) Min Hee Park et al.   STEM CELLS

Osteoblastic Actions of the Neuropeptide Y System to Regulate Bone and Energy Homeostasis

(2016) Harry Horsnell et al.   Current Osteoporosis Reports

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor

(2016) Zhifang Xu et al.   Scientific Reports

Role of neuropeptide Y in the bone marrow hematopoietic stem cell microenvironment

(2015) Min Hee Park et al.   BMB Reports

Vasoactive intestinal peptide administration after stroke in rats enhances neurogenesis and improves neurological function

(2015) Jie Yang et al.   BRAIN RESEARCH

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures

(2015) Tamás Juhász et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ameliorative Effects of PACAP against Cartilage Degeneration. Morphological, Immunohistochemical and Biochemical Evidence from in Vivo and in Vitro Models of Rat Osteoarthritis

(2015) Salvatore Giunta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis

(2015) K.M. Beavers et al.   OSTEOARTHRITIS AND CARTILAGE

PACAP and VIP signaling in chondrogenesis and osteogenesis

(2015) Tamás Juhász et al.   PEPTIDES

Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis

(2015) Dominique Muschter et al.   PLoS One

ACTH: The forgotten therapy

(2015) Trinidad Montero-Melendez   SEMINARS IN IMMUNOLOGY

Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors

(2015) Ping Zhang et al.   PLoS One

The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases

(2014) D. Ganea et al.   Acta Physiologica

Association between Periodontal Disease and Inflammatory Arthritis Reveals Modulatory Functions by Melanocortin Receptor Type 3

(2014) Trinidad Montero-Melendez et al.   AMERICAN JOURNAL OF PATHOLOGY

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury

(2014) Magdalena K. Kaneva et al.   BIOCHEMICAL PHARMACOLOGY

Levels of neuropeptide Y in synovial fluid relate to pain in patients with knee osteoarthritis

(2014) Lei Wang et al.   BMC MUSCULOSKELETAL DISORDERS

Neuropeptide Y induces potent migration of human immature dendritic cells and promotes a Th2 polarization

(2014) Brigitta Buttari et al.   FASEB JOURNAL

Effects of Neuropeptides and Mechanical Loading on Bone Cell Resorption in Vitro

(2014) Yeong-Min Yoo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Signalling Enhances Osteogenesis in UMR-106 Cell Line

(2014) Tamás Juhász et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Signalling Exerts Chondrogenesis Promoting and Protecting Effects: Implication of Calcineurin as a Downstream Target

(2014) Tamás Juhász et al.   PLoS One

Melanocortin 1 Receptor-Signaling Deficiency Results in an Articular Cartilage Phenotype and Accelerates Pathogenesis of Surgically Induced Murine Osteoarthritis

(2014) Julia Lorenz et al.   PLoS One

Tissue-Engineering Strategies to Repair Chondral and Osteochondral Tissue in Osteoarthritis: Use of Mesenchymal Stem Cells

(2014) Susanne Grässel et al.   Current Rheumatology Reports

Differential Regulatory Role of Pituitary Adenylate Cyclase-Activating Polypeptide in the Serum-Transfer Arthritis Model

(2014) Bálint Botz et al.   Arthritis & Rheumatology

Epidemiology and burden of osteoarthritis

(2013) A. Litwic et al.   BRITISH MEDICAL BULLETIN

Expression of Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and PAC1 in the Periodontal Ligament After Tooth Luxation

(2013) Sayako Nonaka et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Disease-modifying osteoarthritis drugs:in vitroandin vivodata on the development of DMOADs under investigation

(2013) Peter SE Davies et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells

(2013) Toan A. Phan et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuropeptide Y induces secretion of high-mobility group box 1 protein in mouse macrophage via PKC/ERK dependent pathway

(2013) Jiang-Rui Zhou et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuropeptide Y modulates fracture healing through Y1receptor signaling

(2013) Daniela M. Sousa et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inflammatory Mediators Alter Interleukin-17 Receptor, Interleukin-12 and -23 Expression in Human Osteoarthritic and Rheumatoid Arthritis Synovial Fibroblasts: Immunomodulation by Vasoactive Intestinal Peptide

(2013) Mar Carrión et al.   NEUROIMMUNOMODULATION

The innervation of synovium of human osteoarthritic joints in comparison with normal rat and sheep synovium

(2013) A. Eitner et al.   OSTEOARTHRITIS AND CARTILAGE

Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?

(2013) E. Losina et al.   OSTEOARTHRITIS AND CARTILAGE

Correction: Neuropeptide Y Is Produced by Adipose Tissue Macrophages and Regulates Obesity-Induced Inflammation

(2013) Kanakadurga Singer et al.   PLoS One

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR Review 1

(2012) Anthony J Harmar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of synovial fluid and articular cartilage VIP in human osteoarthritic knee: A new indicator of disease severity?

(2012) Wei Jiang et al.   CLINICAL BIOCHEMISTRY

Osteoarthritis, inflammation and obesity

(2012) Francis Berenbaum et al.   CURRENT OPINION IN RHEUMATOLOGY

Role of Proopiomelanocortin-Derived Peptides and Their Receptors in the Osteoarticular System: From Basic to Translational Research

(2012) Markus Böhm et al.   ENDOCRINE REVIEWS

PACAP Controls Adrenomedullary Catecholamine Secretion and Expression of Catecholamine Biosynthetic Enzymes at High Splanchnic Nerve Firing Rates Characteristic of Stress Transduction in Male Mice

(2012) N. Stroth et al.   ENDOCRINOLOGY

Dose-Dependent Expression of Neuronal Injury Markers during Experimental Osteoarthritis Induced by Monoiodoacetate in the Rat

(2012) Joana Ferreira-Gomes et al.   Molecular Pain

Novel, Biocompatible, and Disease Modifying VIP Nanomedicine for Rheumatoid Arthritis

(2012) Varun Sethi et al.   MOLECULAR PHARMACEUTICS

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells

(2012) Dima Abdel-Samad et al.   NEUROPEPTIDES

Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis

(2012) Peter Holzer et al.   NEUROPEPTIDES

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Obesity and Weight Loss in the Treatment and Prevention of Osteoarthritis

(2012) Heather K. Vincent et al.   PM&R

Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies

(2012) Ingrid Langer   Frontiers in Endocrinology

The intriguing mission of neuropeptide Y in the immune system

(2011) Mirjana Dimitrijević et al.   AMINO ACIDS

Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions

(2011) Mario Delgado et al.   AMINO ACIDS

Molecular engineering of short half-life small peptides (VIP, αMSH and γ3MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics

(2011) Sandrine Vessillier et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis

(2011) Po-Chuan Shen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Neuropeptide Y stimulates proliferation and migration in the 4T1 breast cancer cell line

(2011) Philip J. Medeiros et al.   INTERNATIONAL JOURNAL OF CANCER

The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts

(2011) Emma Persson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neuropeptide Y innervation during fracture healing and remodeling

(2010) Hua Long et al.   Acta Orthopaedica

ACTH is a novel regulator of bone mass

(2010) Carlos M. Isales et al.   Annals of the New York Academy of Sciences

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis

(2010) Urška Požgan et al.   BIOLOGICAL CHEMISTRY

Development of Rat Tibia Innervation: Colocalization of Autonomic Nerve Fiber Markers with Growth-Associated Protein 43

(2010) Mariusz Gajda et al.   CELLS TISSUES ORGANS

Synovial fluid β-endorphin level in avascular necrosis, rheumatoid arthritis, and osteoarthritis of the femoral head and knee. A controlled pilot study

(2010) Kálmán Toth et al.   CLINICAL RHEUMATOLOGY

Disease Modifying Osteoarthritis Drugs: Facing Development Challenges and Choosing Molecular Targets

(2010) Marie-Pierre Hellio Le Graverand-Gastineau   CURRENT DRUG TARGETS

Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis

(2010) Hetal B. Patel et al.   FASEB JOURNAL

KDPT, a Tripeptide Derivative of  -Melanocyte-Stimulating Hormone, Suppresses IL-1 -Mediated Cytokine Expression and Signaling in Human Sebocytes

(2010) A. Mastrofrancesco et al.   JOURNAL OF IMMUNOLOGY

ACTH protects against glucocorticoid-induced osteonecrosis of bone

(2010) M. Zaidi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The melanocortin system in articular chondrocytes: Melanocortin receptors, pro-opiomelanocortin, precursor proteases, and a regulatory effect of α-melanocyte-stimulating hormone on proinflammatory cytokines and extracellular matrix components

(2009) Susanne Grässel et al.   ARTHRITIS AND RHEUMATISM

Neuropeptide Y expression and function during osteoblast differentiation - insights from transthyretin knockout mice

(2009) Ana F. Nunes et al.   FEBS Journal

Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity

(2009) John C. Igwe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells

(2009) Azusa Nagata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

(2009) D. Vaudry et al.   PHARMACOLOGICAL REVIEWS

Differential expression of vasoactive intestinal peptide and its functional receptors in human osteoarthritic and rheumatoid synovial fibroblasts

(2008) Yasmina Juarranz et al.   ARTHRITIS AND RHEUMATISM

Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: Altered expression and signal in immune cells

(2008) Mario Delgado et al.   ARTHRITIS AND RHEUMATISM

α-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effectsin Vitroandin Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases

(2008) Thomas Brzoska et al.   ENDOCRINE REVIEWS

A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B *2705 in Sardinia

(2008) F Paladini et al.   GENES AND IMMUNITY

VIP reverses the expression profiling of TLR4-stimulated signaling pathway in rheumatoid arthritis synovial fibroblasts

(2008) Alicia Arranz et al.   MOLECULAR IMMUNOLOGY

Divergent peripheral effects of pituitary adenylate cyclase-activating polypeptide-38 on nociception in rats and mice

(2008) Katalin Sándor et al.   PAIN

Multiple Ligands in Opioid Research

(2008) Steven Ballet et al.   PROTEIN AND PEPTIDE LETTERS

α-MSH inhibits TNF-α-induced matrix metalloproteinase-13 expression by modulating p38 kinase and nuclear factor κB signaling in human chondrosarcoma HTB-94 cells

(2007) S.W. Yoon et al.   OSTEOARTHRITIS AND CARTILAGE

Intrathecal neuropeptide Y reduces behavioral and molecular markers of inflammatory or neuropathic pain

(2007) A. B. Intondi et al.   PAIN