Review
Medicine, Research & Experimental
Chun-Lin Xiao, Wen-Chao Yin, Yan-Chun Zhong, Jia-Quan Luo, Lu-Lin Liu, Wu-Yang Liu, Kai Zhao
Summary: Spinal cord injury is a severe central nervous system injury that leads to sensory and motor dysfunction. The PI3K/Akt signaling pathway plays a key role in the pathological processes and neuronal recovery of spinal cord injury, and its activation can promote neurological function recovery by reducing cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Shun Xu, Jin Wang, Junjie Zhong, Minghao Shao, Jianyuan Jiang, Jian Song, Wei Zhu, Fan Zhang, Haocheng Xu, Guangyu Xu, Yuxuan Zhang, Xiaosheng Ma, Feizhou Lyu
Summary: The study demonstrates that CD73 inhibits microglial pyroptosis by suppressing the activation of NLRP3 inflammasome complexes and reducing GSDMD maturation. CD73 regulates GSDMD expression at the transcriptional level through Foxo1, and forms a positive feedback loop with HIF-1 alpha.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Zhenxin Hu, Lina Xuan, Tingting Wu, Nizhou Jiang, Xiangjun Liu, Jiazhen Chang, Te Wang, Nan Han, Xiliang Tian
Summary: Taxifolin reduces neuroinflammation and microglial pyroptosis after spinal cord injury by inhibiting oxidative stress and regulating the PI3K/AKT signaling pathway. It also promotes axonal regeneration and improves functional recovery. Taxifolin may be a potential therapeutic agent for spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhang
Summary: Baicalin is a natural active ingredient that can cross the blood-brain barrier and has neuroprotective effects on multiple central nervous system diseases. This study investigated the mechanism of action of Baicalin in treating spinal cord injury and found that it can inhibit blood-spinal cord barrier permeability and reduce neuronal apoptosis by activating the PI3K/Akt signaling pathway.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Zhenfei Ding, Ce Dai, Lin Zhong, Rui Liu, Weilu Gao, Hui Zhang, Zongsheng Yin
Summary: The study demonstrated that Nrg1 could effectively convert reactive astrocytes to oligodendrocytes, inhibit astrogliosis, promote remyelination, protect axons, and improve SCI symptoms, suggesting a promising therapeutic strategy for spinal cord repair.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Qinqin Xu, Xiaoling Zhang, Tao Li, Shiying Shao
Summary: This study found that exenatide can restore the Th17/Treg balance in obese diabetic mice by regulating the FoxO1 pathway, thereby improving the progression of diabetes and protecting pancreatic beta-cell function.
MOLECULAR MEDICINE
(2022)
Article
Orthopedics
Chengjun Li, Tian Qin, Yuxin Jin, Jianzhong Hu, Feifei Yuan, Yong Cao, Chunyue Duan
Summary: This study found that cerebrospinal fluid-derived extracellular vesicles (CSF-EVs) can promote vascular regeneration and improve motor function recovery after spinal cord injury (SCI) by activating the PI3K/AKT pathway. This provides a potential novel therapeutic approach for the treatment of acute SCI.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Pharmacology & Pharmacy
Renkan Zhang, Ling Xie, Fangfang Wu, Ji Xu, Leilei Lu, Lin Cao, Lei Li, Weiyang Meng, Hongyu Zhang, Chuxiao Shao, Xiaokun Li, Daqing Chen
Summary: Promoting blood-spinal cord barrier (BSCB) repair at the early stage plays a crucial role in treatment of spinal cord injury (SCI). A sustained-release system of basic fibroblast growth factor (bFGF) (called ALG-bFGF) has been developed using sodium alginate hydrogel, which shows improved therapeutic effect in promoting SCI repair and motor function recovery. The mechanism involves the inhibition of autophagy activation and maintenance of BSCB integrity through the PI3K/Akt/FOXO1/KLF4 pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaohui Wang, Chao Jiang, Yongyuan Zhang, Zhe Chen, Hong Fan, Yuyang Zhang, Zhiyuan Wang, Fang Tian, Jing Li, Hao Yang, Dingjun Hao
Summary: The present study aimed to investigate the pro-angiogenic potential of OECs activated by CCM and LPS and the underlying mechanisms. The activated OECs were found to effectively promote proliferation, migration, and vessel-like structure formation of vascular endothelial cells. Several pro-angiogenic growth factors were significantly elevated in the conditioned medium (CM), and the PI3K/Akt signaling pathway was involved in these pro-angiogenic events. Transplantation of activated OECs improved angiogenesis and the microenvironment in the injured spinal cord.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Xiaosi Hu, Shuai Zhou, Haohao Li, Zehui Wu, Ye Wang, Lei Meng, Zhangming Chen, Zhijian Wei, Qing Pang, Aman Xu
Summary: This study found that MND1 is highly expressed in gastric cancer and is associated with resistance to the chemotherapy drug oxaliplatin. Overexpression of MND1 is linked to worse prognosis and advanced pathological characteristics in gastric cancer patients. FOXA1 regulates gastric cancer progression by inhibiting the transcription of MND1. The interaction between MND1 and TKT activates the PI3K/AKT signaling pathway, promoting gastric cancer progression.
CANCER CELL INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Qianqian Zhang, Ruby Feng, Omar Chaudhary, Eitezaz Mahmood, Yanick Baribeau, Rayan Rashid, Kamal R. Khabbaz, Louis M. Chu, David C. Liu, Venkatachalam Senthilnathan, Jessica Cassavaugh, Feroze Mahmood, Simon C. Robson, Robina Matyal
Summary: This study found that compared with nondiabetic patients, there was no significant upregulation of FOXO3 alpha in diabetic patients after cardiopulmonary bypass surgery, which may explain the lack of upregulation of the autophagy process. FOXO3 alpha could potentially serve as a therapeutic target to improve cellular homeostasis.
ANNALS OF THORACIC SURGERY
(2021)
Article
Neurosciences
Sheng Fang, Hao Tang, Hai-long Li, Ti-Chao Han, Zi-Jie Li, Zong-Sheng Yin, Jian-Jun Chu
Summary: In this study, the importance of CCL2 and the PI3K/Akt signaling pathway in inflammation related to spinal cord injury (SCI) were investigated. It was found that CCL2 can regulate cellular inflammatory response through the PI3K/Akt signaling pathway, suggesting that blocking CCL2 expression may be a promising strategy for treating secondary injury after SCI.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weiguo Wang, Xinjie Jiang, Fei Xia, Xudong Chen, Guojun Li, Lizhuan Liu, Qiang Xu, Min Zhu, Cheng Chen
Summary: The study found that HYOU1 is highly expressed in BCa tissues and cells, and is associated with histological grade and pathologic stage of bladder cancer. HYOU1 promotes cell proliferation, migration, and invasion, while inhibiting apoptosis, thus playing a crucial role in BCa progression. Furthermore, the study revealed the involvement of the HYOU1/PI3K-AKT/FOXO1 negative feedback loop in BCa cell functions.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yunxiang Chen, Zijian Wei, Jun Liu, Hao Xie, Binbin Wang, Ji Wu, Zezhang Zhu, Yuejun Fan
Summary: The study demonstrated that ZFAS1 promotes SCI progression by binding with miR-1953 and regulating the PTEN/PI3K/AKT pathway, which may offer a novel insight for SCI treatment.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Sheng Fang, Hao Tang, Ming-Zhi Li, Jian-Jun Chu, Zong-Sheng Yin, Qi-Yu Jia
Summary: The authors conducted an in-depth bioinformatics analysis and found that the expression of autophagy gene CCL2 was upregulated and the PI3K/Akt/mTOR signaling pathway was activated after spinal cord injury (SCI). They verified the results through animal and cellular models and discovered that inhibiting CCL2 expression and activating the PI3K/Akt/mTOR pathway can inhibit autophagy and apoptosis, providing a promising strategy for SCI treatment.
METABOLIC BRAIN DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Ting Zhang, Xu Han, Hong Liu, Marti Biset-Peiro, Jian Li, Xuan Zhang, Pengyi Tang, Bo Yang, Lirong Zheng, Joan Ramon Morante, Jordi Arbiol
Summary: Regulating the coordination environment with heteroatoms allows the construction of metal-nitrogen-carbon catalysts for electrochemical CO2 reduction. This study presents a facile method to create axial O-coordinated FeN4 active sites using an oxygen- and nitrogen-rich metal-organic framework as the precursor. The O-coordinated active sites exhibit improved catalytic performance compared to non-O-coordinated sites.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Dawei Yang, Zhifu Liang, Pengyi Tang, Chaoqi Zhang, Mingxue Tang, Qizhen Li, Jordi Jacas Biendicho, Junshan Li, Marc Heggen, Rafal E. Dunin-Borkowski, Ming Xu, Jordi Llorca, Jordi Arbiol, Joan Ramon Morante, Shu-Lei Chou, Andreu Cabot
Summary: In this study, a 1D pi-d conjugated metal-organic framework (MOF), Ni-MOF-1D, is presented as an efficient sulfur host to overcome the shuttling behavior and sluggish conversion kinetics of intermediate lithium polysulfides (LiPS) in lithium-sulfur batteries (LSBs). Ni-MOF-1D exhibits a remarkable binding strength to trap soluble LiPS species and acts as an effective catalyst for S reduction and Li2S oxidation. The delocalization of electrons in the pi-d system of Ni-MOF-1D provides superior electrical conductivity, leading to excellent performance in LSBs.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Pengfei Cao, Pengyi Tang, Maged F. Bekheet, Hongchu Du, Luyan Yang, Leander Haug, Albert Gili, Benjamin Bischoff, Aleksander Gurlo, Martin Kunz, Rafal E. Dunin-Borkowski, Simon Penner, Marc Heggen
Summary: By using a combination of in situ characterization techniques, we investigated the surface and bulk dynamics of LaNiO3 material during heating in vacuo, revealing the Ni exsolution dynamics on both local and global scales. The remaining perovskite grains exhibited a drastic shrinkage and compression of structure after the Ni exsolution, mainly occurring at grain boundaries and stacking faults.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Anatomy & Morphology
Zhongkui Guo, Yi Li, Ming Chen, Ya Gu, Yang Chen, Yanpeng Zhao, Peifu Tang
Summary: This study found that Semaphorin3A (Sema3A) induces apoptosis of osteoclasts by promoting mitochondrial apoptosis. Sema3A inhibits the activation of the ERK/JNK/AKT pathway and significantly increases the expression levels of cleaved-caspase-3 and cleaved-caspase-9.
Article
Engineering, Biomedical
Qinyu Yue, Lele Lei, Ya Gu, Ruijin Chen, Mingming Zhang, Haikuan Yu, Shang Li, Luming Yang, Yixin Zhang, Xiaoduo Zhao, Qiangbing Wei, Shuanhong Ma, Licheng Zhang, Peifu Tang, Feng Zhou
Summary: This study presents the development of highly efficient and biocompatible biomimetic lubricants for arthritis treatment and artificial joint lubrication. The use of natural polysaccharide (chitosan) and zwitterionic poly[2-(methacryloyloxy) ethyl phosphorylcholine] (PMPC) in the formation of brush-like Chitosan-g-PMPC copolymers is shown. These copolymers exhibit excellent lubrication properties and good biocompatibility, making them a promising solution for arthritis treatment and joint lubrication.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Physical
Yongmin He, Liren Liu, Chao Zhu, Shasha Guo, Prafful Golani, Bonhyeong Koo, Pengyi Tang, Zhiqiang Zhao, Manzhang Xu, Peng Yu, Xin Zhou, Caitian Gao, Xuewen Wang, Zude Shi, Lu Zheng, Jiefu Yang, Byungha Shin, Jordi Arbiol, Huigao Duan, Yonghua Du, Marc Heggen, Rafal E. Dunin-Borkowski, Wanlin Guo, Qi Jie Wang, Zhuhua Zhang, Zheng Liu
Summary: A wafer-size amorphous PtSex film with high atom-utilization efficiency has been fabricated through a low-temperature amorphization strategy. This film acts as a single-atom-layer catalyst for high-flux hydrogen production and can potentially be extended to other noble metals.
Article
Nanoscience & Nanotechnology
Xu Han, Ting Zhang, Marti Biset-Peiro, Xuan Zhang, Jian Li, Weiqiang Tang, Pengyi Tang, Joan Ramon Morante, Jordi Arbiol
Summary: The study successfully improved the selectivity and efficiency of CO2 reduction reaction by preparing a CO2-philic hydroxyl coordinated ZnO catalyst. The calculated and experimental results demonstrate that the coordinated surficial -OH groups can promote the adsorption and activation of CO2, as well as inhibit undesired hydrogen evolution reaction.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Lichen Zhao, Pengyi Tang, Deying Luo, M. Ibrahim Dar, Felix T. Eickemeyer, Neha Arora, Qin Hu, Jingshan Luo, Yuhang Liu, Shaik Mohammed Zakeeruddin, Anders Hagfeldt, Jordi Arbiol, Wei Huang, Qihuang Gong, Thomas P. Russell, Richard H. Friend, Michael Gratzel, Rui Zhu
Summary: Researchers have successfully mitigated grain boundaries in perovskite solar cells at both nano and submicron scales, leading to improved device efficiency and stability under various stress conditions.
Article
Orthopedics
Xuedong Bai, Zhengguo Zhu, Zuhao Chang, Lijun Sun, Peifu Tang, Hua Chen
Summary: This study introduces a novel intramedullary support nail and plate system (ISNPs) for the internal fixation of complex proximal humeral fractures (PHF) in older adults. The clinical results confirm the advantage of using ISNPs in terms of reduction quality and patients' subjective evaluation.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Engineering, Biomedical
Zhengguo Zhu, Zuhao Chang, Wei Zhang, Shaobo Nie, Lin Qi, Peifu Tang, Hua Chen, Yujie Liu
Summary: This study aimed to compare the biomechanical properties of different lengths of fibula with or without calcar screw in osteoporotic proximal humeral fracture. The results showed that the groups with a 12-cm fibular strut had significant improvement in terms of initial stiffness, number of cycles loaded to failure, and relative displacement values compared to the groups with a 6-cm fibular strut, regardless of calcar screw implementation. Furthermore, the groups with calcar screws also demonstrated promising biomechanical stability irrespective of fibular length. Therefore, the use of lateral locking plate with longer endosteal fibular augmentation and calcar screw can significantly improve biomechanical stability for elderly proximal humeral fractures with posteromedial comminution.
CLINICAL BIOMECHANICS
(2023)
Article
Surgery
Gaoxiang Xu, Daofeng Wang, Hao Zhang, Cheng Xu, Hua Li, Wupeng Zhang, Jiantao Li, Licheng Zhang, Peifu Tang
Summary: This study aims to screen patients with osteoporosis and predict their clinical outcomes using effective parameters obtained from hip CT scans. The cortical bone thickness (CTh) of ROI 21 and Hounsfield unit (HU) values of ROI 14 were moderately correlated with hip BMD. Thresholds for osteoporosis based on CTh and HU values could accurately screen osteoporosis, and the clinical outcomes of nonosteoporotic group were better than those of osteoporotic group.
FRONTIERS IN SURGERY
(2023)
Article
Energy & Fuels
Jordi Jacas Biendicho, Pedro Mazaira, Hemesh Avireddy, Chaoqi Zhang, Pengyi Tang, Alexander Missyul, Lluis Trilla, Jordi Arbiol, Joan Ramon Morante, Andreu Cabot
Summary: A new cathode material, FeS2-decorated carbon nanofiber (CNF), has been proposed for Li-S batteries to enhance the cycling stability typically displayed by sulfur composites. The composite material shows a complex architecture with a CNF matrix hosting the sulfur and FeS2 nanoparticles acting as a catalyst. The FeS2-decorated CNF cathode delivers high discharge capacities and stable capacity retention, making it highly promising for the next generation of electrochemical energy storage devices.
Article
Chemistry, Multidisciplinary
Guangping Yi, Qiang Wang, Jordi Arbiol, Pengyi Tang
Summary: This article systematically summarizes the main strategies for enhancing the efficiency and stability of silicon photoelectrodes for photoelectrochemical catalysis. It focuses on five metal oxide/nitride protection layers, including TiO2, NiOx, CoOx, Al2O3, and GaN. The review presents the basic properties, synthesis processes, operation mechanisms, and application cases of these protective layers on silicon substrates. It concludes by highlighting the suitable application scenarios and optimization solutions based on the characteristics of each protective layer, and discusses the current challenges and future outlook for Si-based photoelectrodes.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tong Li, Qiuxia Wang, Jingjing Wu, Yanping Sui, Pengyi Tang, Haiting Liu, Wenjie Zhang, Huaming Li, Yong Wang, Andreu Cabot, Junfeng Liu
Summary: In this study, Pd3Pb@Pt core-shell nanocubes with controlled shell thickness were synthesized using Pt-seeded epitaxial growth on intermetallic Pd3Pb cores. The lattice mismatch between the Pd3Pb core and the Pt shell resulted in the expansion of the Pt lattice, leading to excellent electrocatalytic performance for both ethanol oxidation reaction (EOR) and hydrogen evolution reaction (HER).
Article
Multidisciplinary Sciences
Ru Yi Zhang, Jian Tao Li, Jing Xin Zhao, Zhe Zhao, Li Cheng Zhang, Cai Yun, Xiu Yun Su, Pei Fu Tang
Summary: This study aimed to explore a novel oblique triangle configuration (OTC) of three screws for fixing femoral neck fractures based on the morphology of the femoral neck isthmus (FNI). The OTC method provided an ideal spatial configuration for the FNA fixation with the largest area using three parallel screws. The positioning of the posterior screw also reduced the risk of vascular injury and screw penetrating.
SCIENTIFIC REPORTS
(2022)
