Review
Oncology
Guangbing Xiong, Shutao Pan, Jikuan Jin, Xiaoxiang Wang, Ruizhi He, Feng Peng, Xu Li, Min Wang, Jianwei Zheng, Feng Zhu, Renyi Qin
Summary: The study provides a comprehensive review of the role of lncRNAs and miRNAs in the initiation and progression of pancreatic cancer, highlighting the crucial function of ceRNA networks in the biological processes of pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuxi Wu, Xiaoying Wu, Jiahuan Wang, Sifan Chen, Hongxing Chen, Jing Liu, Tingting Zeng, Mengdie Hu, Ying Liang, Kan Sun, Chuan Yang, Li Yan, Meng Ren
Summary: The enrichment of long noncoding RNA upregulated in diabetic skin (lnc-URIDS) in fibroblast-derived extracellular vesicles (Fib-EVs) was induced by high glucose, facilitating the transfer of lnc-URIDS to primary rat epidermal keratinocytes and increasing the expression of matrix metalloproteinase-9. Mechanistically, lnc-URIDS binding to YTH domain family protein-2 enhanced its degradation in the lysosomes, resulting in increased translational activity of matrix metalloproteinase-9 mRNA and ultimately leading to collagen degradation for diabetic wound healing.
LABORATORY INVESTIGATION
(2023)
Article
Dermatology
Yizhao Ma, Zhifang Liu, LinLin Miao, Xinyu Jiang, Hongyu Ruan, Rongrong Xuan, Suling Xu
Summary: Pathological scarring is caused by excessive proliferation and transdifferentiation of fibroblasts, as well as excessive deposition of extracellular matrix during wound healing. Factors that promote pathological scar formation affect the proliferation and function of fibroblasts. This study explores the microenvironment, signaling pathways, epigenetics, and autophagy related to the abnormal formation of fibroblasts in pathological scarring. Understanding the causes of abnormal fibroblast formation may lead to improved prevention and treatment strategies for pathological scarring and enhance patients' quality of life.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Engineering, Biomedical
Yueming Xue, Chunxiao Qi, Yunsheng Dong, Lin Zhang, Xiangsheng Liu, Yufei Liu, Shufang Wang
Summary: The new hydrogel developed in this project shows potential in inhibiting overgrowth of scars and promoting cell adhesion, providing a new treatment option for treating serious skin disorders.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Genetics & Heredity
Zifan Yue, Pei Mou, Sainan Chen, Fei Tong, Ruili Wei
Summary: A study investigated the lncRNA/circRNA-miRNA-mRNA network in Graves' ophthalmopathy (GO) patients, revealing significant differences in RNA expression levels compared to control patients. Through high-throughput sequencing and qPCR validation, the study identified key genes and constructed ceRNA networks. This innovative study identified two important ceRNA pathways that may impact autoimmune response and inflammation in GO patients.
FRONTIERS IN GENETICS
(2021)
Review
Engineering, Chemical
Fernanda Costa Brandao Berti, Sara Cristina Lobo-Alves, Camila de Freitas Oliveira-Tore, Amanda Salviano-Silva, Karen Brajao de Oliveira, Patricia Savio de Araujo-Souza, Jong Kook Park, Gabriel Adelman Cipolla, Danielle Malheiros
Summary: MicroRNAs regulate gene expression by binding to target mRNAs, while interacting in competitive ceRNA networks. Long noncoding RNAs play essential roles in cervical cancer, impacting cell processes by modulating miRNA sponging. This dynamic molecular interaction affects cell growth, proliferation, apoptosis, and adhesion in CC.
Review
Cell & Tissue Engineering
Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang
Summary: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar-free wound repair has been greatly expanded. This paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on scar prevention and strategies for scar-free wound repair.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Immunology
Jiayi Yin, Shiming Zhang, Chao Yang, Yan Wang, Bing Shi, Qian Zheng, Ni Zeng, Hanyao Huang
Summary: Mechanical forces play a significant role in scar formation and skin regeneration, understanding these mechanisms is crucial for the development of effective scar therapies. This review provides an overview of the current understanding of mechanotransduction signaling pathways and strategies for reducing mechanical forces in the injured area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Li-Wei Meng, Guo-Rui Yuan, Meng-Ling Chen, Li-Sha Zheng, Wei Dou, Yu Peng, Wen-Jie Bai, Zhen-Yu Li, John Vontas, Jin-Jun Wang
Summary: The insect cuticle contributes over 40.0% to insecticide resistance, and miR-994 and CPCFC play key roles in regulating cuticle thickness and insecticide penetration.
Article
Oncology
Ke-zhi Li, Yi-xin Yin, Yan-ping Tang, Long Long, Ming-zhi Xie, Ji-lin Li, Ke Ding, Bang-li Hu
Summary: Right-sided and left-sided colon cancers have distinct clinical and molecular characteristics. This study identified location-specific lncRNAs as ceRNAs in colon cancer and established a DEL-based prognostic signature. These differences can be used to assess prognosis and determine treatment strategies for patients with colon cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiao-Feng Cui, Si-Lin Zhang, Wei-Ping Wang, Xiao-Wu Huang, Xiang-Jun Chen
Summary: In this study, key long noncoding RNAs (lncRNAs) involved in the competitive endogenous RNA (ceRNA) network associated with laryngeal squamous cell carcinoma (LSCC) were investigated. Through functional enrichment analysis and construction of the ceRNA regulatory network, the functions of these lncRNAs and their importance in LSCC were determined. The results were further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis.
Article
Biochemistry & Molecular Biology
Bo Li, Yue Zhou, Jing Chen, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong Bi
Summary: Aberrant expressions of lncRNA H19 and miR-29b have been implicated in the complications of diabetes mellitus, specifically in diabetic foot ulcer (DFU). Upregulation of lncRNA H19 in DFU tissues competitively binds to miR-29b, leading to increased expression of FBN1, which enhances fibroblast proliferation and migration while inhibiting apoptosis, ultimately facilitating wound healing in DFU.
Article
Immunology
Hani Sabaie, Zoha Salkhordeh, Mohammad Reza Asadi, Soudeh Ghafouri-Fard, Nazanin Amirinejad, Mahla Askarinejad Behzadi, Bashdar Mahmud Hussen, Mohammad Taheri, Maryam Rezazadeh
Summary: This study aimed to clarify the molecular regulatory mechanisms involved in T-cells responses in MS by exploring the lncRNA-associated ceRNA axes. The research identified a ceRNA regulatory relationship among SNHG1, hsa-miR-197-3p, YOD1, ZNF101 and downstream connected genes, potentially playing a role in the pathogenesis of MS. Pathway enrichment analysis showed that differentially expressed mRNAs were enriched in Protein processing in endoplasmic reticulum and Herpes simplex virus 1 infection pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Sen Ren, Hewei Xiong, Jing Chen, Xiaofan Yang, Yutian Liu, Jiahe Guo, Tao Jiang, Zhao Xu, Meng Yuan, Yang Liu, Nan Zhou, Hongrui Chen, Wenqing Li, Hans-Gunther Machens, Zhenbing Chen
Summary: Our research identified differentially expressed RNAs in ASCs from diabetic, old, and young donors, revealing that ASCs from diabetic and old donors exhibit impaired functionality compared to those from young donors. Furthermore, it was found that overexpression of miR-145-5p could rejuvenate the phenotype of old ASCs and enhance their functionality, providing potential targets for restoring therapeutic properties in ASCs.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cardiac & Cardiovascular Systems
Wei Xiong, Shiyan Feng, Yanhua Zhao, Xinquan Liu, Jian Gong
Summary: Cardiovascular dysfunction induced by sepsis is a common and urgent health problem worldwide, but the exact pathogenesis and pathophysiology are still unclear. Recent research has focused on competing endogenous RNA (ceRNA) networks, which play a role in the progression of sepsis-related cardiovascular diseases. This review explores the potential regulatory mechanism of ceRNA networks in sepsis-induced cardiovascular toxicity, in hopes of providing new therapeutic strategies and monitoring targets for sepsis-related CVDs.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)