Review
Oncology
Guangbing Xiong, Shutao Pan, Jikuan Jin, Xiaoxiang Wang, Ruizhi He, Feng Peng, Xu Li, Min Wang, Jianwei Zheng, Feng Zhu, Renyi Qin
Summary: The study provides a comprehensive review of the role of lncRNAs and miRNAs in the initiation and progression of pancreatic cancer, highlighting the crucial function of ceRNA networks in the biological processes of pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiao-Feng Cui, Si-Lin Zhang, Wei-Ping Wang, Xiao-Wu Huang, Xiang-Jun Chen
Summary: In this study, key long noncoding RNAs (lncRNAs) involved in the competitive endogenous RNA (ceRNA) network associated with laryngeal squamous cell carcinoma (LSCC) were investigated. Through functional enrichment analysis and construction of the ceRNA regulatory network, the functions of these lncRNAs and their importance in LSCC were determined. The results were further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis.
Article
Genetics & Heredity
Zifan Yue, Pei Mou, Sainan Chen, Fei Tong, Ruili Wei
Summary: A study investigated the lncRNA/circRNA-miRNA-mRNA network in Graves' ophthalmopathy (GO) patients, revealing significant differences in RNA expression levels compared to control patients. Through high-throughput sequencing and qPCR validation, the study identified key genes and constructed ceRNA networks. This innovative study identified two important ceRNA pathways that may impact autoimmune response and inflammation in GO patients.
FRONTIERS IN GENETICS
(2021)
Review
Engineering, Chemical
Fernanda Costa Brandao Berti, Sara Cristina Lobo-Alves, Camila de Freitas Oliveira-Tore, Amanda Salviano-Silva, Karen Brajao de Oliveira, Patricia Savio de Araujo-Souza, Jong Kook Park, Gabriel Adelman Cipolla, Danielle Malheiros
Summary: MicroRNAs regulate gene expression by binding to target mRNAs, while interacting in competitive ceRNA networks. Long noncoding RNAs play essential roles in cervical cancer, impacting cell processes by modulating miRNA sponging. This dynamic molecular interaction affects cell growth, proliferation, apoptosis, and adhesion in CC.
Article
Oncology
Guiwen Ye, Peng Wang, Zhongyu Xie, Jinteng Li, Guan Zheng, Wenjie Liu, Qian Cao, Ming Li, Shuizhong Cen, Zhaofeng Li, Wenhui Yu, Yanfeng Wu, Huiyong Shen
Summary: This study identified a novel long noncoding RNA, HHAS1, that facilitates bone marrow-derived mesenchymal stem cell osteogenic differentiation, and proposed a role for the IRF2/HHAS1/miR-204-5p/RUNX2 axis in the regulation of BMSC osteogenesis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Neda Mokhberian, Kazem Sharifi, Ehsan Soleimaninejadian, Mohamad Eftekhary, Seyed Mahmoud Hashemi, Shohreh Farhadi, Satomi Miwa, Hossein Ghanbarian
Summary: This study demonstrates that upregulation of SIRT1 can be achieved by knocking down the natural antisense transcript SIRT1-NAT, leading to improved therapeutic potentials of human MSCs. Knockdown of SIRT1-NAT enhances the proliferation and differentiation abilities of MSCs, reduces senescence-associated activity, and reverses senescence-associated molecular changes.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Li-Wei Meng, Guo-Rui Yuan, Meng-Ling Chen, Li-Sha Zheng, Wei Dou, Yu Peng, Wen-Jie Bai, Zhen-Yu Li, John Vontas, Jin-Jun Wang
Summary: The insect cuticle contributes over 40.0% to insecticide resistance, and miR-994 and CPCFC play key roles in regulating cuticle thickness and insecticide penetration.
Review
Oncology
Marco De Martino, Francesco Esposito, Maria Capone, Pierlorenzo Pallante, Alfredo Fusco
Summary: Thyroid tumors are the most common neoplastic pathology of the endocrine system, with mutations in oncogenes and tumor suppressor genes playing a role in their development. Noncoding RNAs have been found to be crucial in regulating gene expression and tumor progression in thyroid cancer. Evaluating the noncoding RNA network could lead to a more personalized approach in the diagnosis, prognosis, and treatment of thyroid cancer.
Review
Cell Biology
Talan Tran, Claudia Cruz, Anthony Chan, Salma Awad, Johnson Rajasingh, Richard Deth, Narasimman Gurusamy
Summary: This review focuses on the importance and potential roles of MSC-derived lncRNAs in cardiac regeneration. Understanding the molecular mechanisms of lncRNAs involved in cardiac repair and regeneration may contribute to the development of novel therapeutic strategies for cardiovascular diseases.
Article
Genetics & Heredity
Gui Wan, Zhao Xu, Xuejiao Xiang, Maojie Zhang, Tao Jiang, Jing Chen, Shengbo Li, Cheng Wang, Chengqi Yan, Xiaofan Yang, Zhenbing Chen
Summary: This study aims to elucidate the mechanism of endothelial progenitor cell (EPC) dysfunction in diabetes. Transcriptome analysis revealed that EPCs derived from diabetic rats displayed suppressed proliferation, migration, and tube formation ability. Differential gene expression analysis identified genes related to EPC function and wound healing. Protein-protein interaction networks and lncRNA-miRNA-mRNA ceRNA network further confirmed key regulatory genes. The findings shed light on the understanding of EPC dysfunction in diabetes and provided potential targets for accelerating wound healing.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemistry & Molecular Biology
Qiwei Liu, Yu Zhao, Qian Wang, Li Yan, Xin Fu, Ran Xiao
Summary: Through analyzing single-cell RNA sequencing data of adipose-derived stem cells (ASCs) from different age groups, it was found that ASCs showed a loss of heterogeneity with aging, and the subtype ASC-4 became dominant. ASC-4 displayed increased adipogenic ability with age persistently. In addition, age-associated upregulation of inflammatory factors including CCL2 and CCL7 was identified, which could promote adipogenesis and enhance inflammatory responses in ASCs.
Article
Biochemistry & Molecular Biology
Qiwei Liu, Yu Zhao, Qian Wang, Li Yan, Xin Fu, Ran Xiao
Summary: This study analyzed single-cell transcriptomic data of adipose-derived stem cells (ASCs) from different age groups and found that aging led to a decrease in ASC heterogeneity, with subtype 4 (ASC-4) becoming the dominant population in aged ASCs. The study also identified the transcription factor Cebpb as specific to ASC-4 and observed an upregulation of age-associated inflammatory response factors CCL2 and CCL7. The findings have implications for regenerative and therapeutic applications of ASCs.
Article
Oncology
Xiao-Jun Wang, Jing Gao, Qin Yu, Min Zhang, Wei-Dong Hu
Summary: This study integrated multi-omics profiles to elucidate ceRNA characteristics, pathways, and drug candidates in SCLC, identifying downregulated mRNAs (CSF3R/GAA), lncRNAs (AC005005.4-201/DLX6-AS1-201/NEAT1-203), circRNAs (hsa_HLA-B_1/hsa_VEGFC_8), and upregulated miRNAs (hsa-miR-4525/hsa-miR-6747-3p) as part of the ceRNA regulatory networks. Further analysis revealed potential therapeutic targets like CSF3R and GAA, involved in autophagy and glucose metabolism pathways, respectively.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Wei Xiong, Shiyan Feng, Yanhua Zhao, Xinquan Liu, Jian Gong
Summary: Cardiovascular dysfunction induced by sepsis is a common and urgent health problem worldwide, but the exact pathogenesis and pathophysiology are still unclear. Recent research has focused on competing endogenous RNA (ceRNA) networks, which play a role in the progression of sepsis-related cardiovascular diseases. This review explores the potential regulatory mechanism of ceRNA networks in sepsis-induced cardiovascular toxicity, in hopes of providing new therapeutic strategies and monitoring targets for sepsis-related CVDs.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Litao Yan, Gejun Liu, Xing Wu
Summary: This study found that exosomal lncRNA H19 derived from UMSCs acts as a competing endogenous RNA to enhance osteochondral activity in chondrocytes by sequestering miR-29b-3p. Injection of exosomes overexpressing H19 promoted sustained cartilage repair, highlighting its potential for developing strategies against cartilage defects.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Guojun Guo, Yutian Liu, Sen Ren, Yu Kang, Dominik Duscher, Hans-Guenther Machens, Zhenbing Chen
Article
Cell & Tissue Engineering
Sen Ren, Jing Chen, Dominik Duscher, Yutian Liu, Guojun Guo, Yu Kang, Hewei Xiong, Peng Zhan, Yang Wang, Cheng Wang, Hans-Guenther Machens, Zhenbing Chen
STEM CELL RESEARCH & THERAPY
(2019)
Article
Cell Biology
Jing Chen, Sen Ren, Dominik Duscher, Yu Kang, Yutian Liu, Cheng Wang, Meng Yuan, Guojun Guo, Hewei Xiong, Peng Zhan, Yang Wang, Hans-Guenther Machens, Zhenbing Chen
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell & Tissue Engineering
Yu Kang, Yutian Liu, Zhenyu Liu, Sen Ren, Hewei Xiong, Jing Chen, Dominik Duscher, Hans-Guenther Machens, Wei Liu, Guojun Guo, Peng Zhan, Hongrui Chen, Zhenbing Chen
Article
Biochemistry & Molecular Biology
Guojun Guo, Sen Ren, Yu Kang, Yutian Liu, Dominik Duscher, Hans-Guenther Machens, Zhenbing Chen
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
Cheng Wang, Xiang Xu, Jing Chen, Yu Kang, Jiahe Guo, Dominik Duscher, Xiaofan Yang, Guojun Guo, Sen Ren, Hewei Xiong, Meng Yuan, Tao Jiang, Hans-Guenther Machens, Zhenbing Chen, Yanhua Chen
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Review
Cell Biology
Yang Liu, Xiaofan Yang, Yutian Liu, Tao Jiang, Sen Ren, Jing Chen, Hewei Xiong, Meng Yuan, Wenqing Li, Hans-Gunther Machens, Zhenbing Chen
Summary: The NRF2 signaling pathway plays a crucial role in wound healing by regulating anti-inflammatory and antioxidant effects, and it has important clinical significance in this process.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Boping Jing, Ruijie Qian, Dawei Jiang, Yongkang Gai, Zhen Liu, Feng Guo, Sen Ren, Yu Gao, Xiaoli Lan, Rui An
Summary: In this study, an extracellular vesicles-based nanoprobe was synthesized for visualizing colon cancer with PET/CT and NIRF imaging, showing promising results in preoperative evaluation and image-guided surgery in animal models. The nanoprobe showed a strong binding ability to tumor cells and achieved clear imaging results using PET/CT and NIRF imaging techniques. This study suggests the potential clinical application of extracellular vesicles as nanocarriers for multi-modal imaging and image-guided surgery of colon cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Qianyun Li, Kun Liu, Tao Jiang, Sen Ren, Yu Kang, Wenqing Li, Haibo Yao, Xiaofan Yang, Honglian Dai, Zhenbing Chen
Summary: An injectable self-healing hydrogel based on chitosan and hyaluronic acid was developed for wound healing in diabetic animals, showing significant promotion in the wound healing process. The hydrogel displayed properties of promoting cell proliferation and migration, as well as antioxidant and antibacterial effects.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Nan Zhou, Zhao Xu, Xiang Li, Sen Ren, Jing Chen, Hewei Xiong, Cheng Wang, Jiahe Guo, Yu Kang, Zhenbing Chen, Wenqing Li, Xiaofan Yang, Xing Zhang, Xiang Xu
Summary: This study aimed to induce the differentiation of ADSCs into SCs using SC-Exos and investigate the mechanisms involved through miRNA sequencing. The results showed that SC-Exos were effective in inducing ADSCs differentiation, with differentially expressed miRNAs playing a vital role.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Genetics & Heredity
Xiling Xiao, Xiaofan Yang, Sen Ren, Chunqing Meng, Zhaohui Yang
Summary: This study investigates the synovial tissue profiles following ACL and meniscus injuries to understand the contributing factors of posttraumatic osteoarthritis (PTOA). The results reveal the differential gene expression and immune cell infiltration patterns in the synovium, providing insights into the underlying mechanisms of PTOA. The study identifies potential immune-related biomarkers for PTOA treatment.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Sen Ren, Jing Chen, Jiahe Guo, Yutian Liu, Hewei Xiong, Boping Jing, Xiaofan Yang, Gongchi Li, Yu Kang, Cheng Wang, Xiang Xu, Zhenyu Liu, Maojie Zhang, Kaituo Xiang, Chengcheng Li, Qianyun Li, Hans-Gunther Machens, Zhenbing Chen
Summary: Exosomes derived from adipose-derived stem cells (ADSC-EXOs) can promote diabetic wound healing by modulating oxidative stress. ADSC-EXOs enhance cell proliferation, migration, and angiogenesis, reduce reactive oxygen species levels, and protect cells against hypoxic and oxidative stress damage. The mechanism involves exosomal HSP90 binding to LRP1 on recipient cells, activating the downstream AKT signaling pathway. Knockdown of LRP1 and inhibition of the AKT signaling pathway impair the beneficial effect of ADSC-EXOs, indicating the significance of the exosomal HSP90/LRP1/AKT signaling pathway in diabetic wound closure.
Article
Cell Biology
Yu-Tian Liu, Zhao Xu, Wei Liu, Sen Ren, He-Wei Xiong, Tao Jiang, Jing Chen, Yu Kang, Qian-Yun Li, Zi-Han Wu, Hans-GuNther Machens, Xiao-Fan Yang, Zhen-Bing Chen
Summary: The study found that circRNAs and differentially expressed proteins are involved in diabetic peripheral neuropathy, with circ_0002538 downregulated in patients and promoting the migration of Schwann cells. Overexpressing circ_0002538 improved demyelination and nerve function in a mouse model. The circ_0002538/miR-138-5p/PLLP axis may be a potential therapeutic target for diabetic peripheral neuropathy.
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Biomedical
Tao Jiang, Siju Liu, Zihan Wu, Qianyun Li, Sen Ren, Jing Chen, Xiang Xu, Cheng Wang, Cuifen Lu, Xiaofan Yang, Zhenbing Chen
Summary: The smart hydrogel loaded with ADSC-exo showed promising results in enhancing cell function and accelerating wound healing in diabetic patients.
MATERIALS TODAY BIO
(2022)