Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time

Transcriptional Control of Early T and B Cell Developmental Choices

(2014) Ellen V. Rothenberg   Annual Review of Immunology

Human innate lymphoid cells

(2014) M. D. Hazenberg et al.   BLOOD

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

NK cell development in bone marrow and liver: site matters

(2014) D Gotthardt et al.   GENES AND IMMUNITY

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells

(2014) Ryoji Yagi et al.   IMMUNITY

Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells

(2014) Jun Young Hong et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association of IL33–IL-1 receptor–like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood

(2014) Olga E. Savenije et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nfil3 is required for the development of all innate lymphoid cell subsets

(2014) Cyril Seillet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression

(2014) Victoria Male et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens

(2014) Theresa L. Geiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gata3drives development of RORγt+group 3 innate lymphoid cells

(2014) Nicolas Serafini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Requirement for Nfil3 during NK Cell Development

(2014) C. Seillet et al.   JOURNAL OF IMMUNOLOGY

Composition of Innate Lymphoid Cell Subsets in the Human Skin: Enrichment of NCR + ILC3 in Lesional Skin and Blood of Psoriasis Patients

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

Human CD117 (cKit)+ Innate Lymphoid Cells Have a Discrete Transcriptional Profile at Homeostasis and Are Expanded during Filarial Infection

(2014) Alexis Boyd et al.   PLoS One

Developmental programming of natural killer and innate lymphoid cells

(2013) Christian AJ Vosshenrich et al.   CURRENT OPINION IN IMMUNOLOGY

T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation

(2013) Qi Yang et al.   IMMUNITY

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Intestinal Lin-c-Kit+NKp46-CD4- Population Strongly Produces IL-22 upon IL-1  Stimulation

(2013) Y. Lee et al.   JOURNAL OF IMMUNOLOGY

TCF-1 Controls ILC2 and NKp46+ROR t+ Innate Lymphocyte Differentiation and Protection in Intestinal Inflammation

(2013) L. A. Mielke et al.   JOURNAL OF IMMUNOLOGY

TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers

(2013) X Yu et al.   Mucosal Immunology

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

(2013) Lucille C Rankin et al.   NATURE IMMUNOLOGY

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

Group 2 Innate Lymphoid Cell Production of IL-5 Is Regulated by NKT Cells during Influenza Virus Infection

(2013) Stacey Ann Gorski et al.   PLoS Pathogens

Transcriptional drivers of the T-cell lineage program

(2012) Ellen V Rothenberg   CURRENT OPINION IN IMMUNOLOGY

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

(2012) Nick Powell et al.   IMMUNITY

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells

(2012) Jenny Mjösberg et al.   IMMUNITY

The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

(2012) Thomas Hoyler et al.   IMMUNITY

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation

(2012) Scott M. Gordon et al.   IMMUNITY

Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells

(2012) Marie Cherrier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

(2012) A. Gladiator et al.   JOURNAL OF IMMUNOLOGY

Transcription factor RORα is critical for nuocyte development

(2012) See Heng Wong et al.   NATURE IMMUNOLOGY

Identification of the earliest NK-cell precursor in the mouse BM

(2011) S. Carotta et al.   BLOOD

Identification of the earliest natural killer cell-committed progenitor in murine bone marrow

(2011) J. W. Fathman et al.   BLOOD

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

Id2 expression delineates differential checkpoints in the genetic program of CD8α+and CD103+dendritic cell lineages

(2011) Jacob T Jackson et al.   EMBO JOURNAL

NK cells can generate from precursors in the adult human liver

(2011) Viviana Moroso et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Notch signaling is necessary for adult, but not fetal, development of RORγt+ innate lymphoid cells

(2011) Cécilie Possot et al.   NATURE IMMUNOLOGY

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

(2010) Tetsuro Takayama et al.   GASTROENTEROLOGY

Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

(2010) Cedric Vonarbourg et al.   IMMUNITY

CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut

(2010) Gregory F. Sonnenberg et al.   IMMUNITY

Human NKp44+IL-22+cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells

(2010) Natasha K. Crellin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+cell subsets from Id2-dependent precursors

(2010) Naoko Satoh-Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immature NK Cells, Capable of Producing IL-22, Are Present in Human Uterine Mucosa

(2010) V. Male et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Thymic NK Cells Develop Independently from T Cell Precursors

(2010) V. S. G. Ribeiro et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

(2010) Hergen Spits et al.   NATURE IMMUNOLOGY

Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue–inducer cell and NK cell lineages

(2010) Parinaz Aliahmad et al.   NATURE IMMUNOLOGY

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1  reveals intrinsic functional plasticity

(2010) M. Cella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion

(2010) P. Li et al.   SCIENCE

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b

(2010) L. Li et al.   SCIENCE

Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22

(2009) T. Hughes et al.   BLOOD

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

(2009) Emily A. Stevens et al.   IMMUNOLOGY

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

(2009) Shintaro Kamizono et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-7 Regulates the Peripheral Pool of Adult ROR + Lymphoid Tissue Inducer Cells

(2009) S. Schmutz et al.   JOURNAL OF IMMUNOLOGY

The development of intestinal lymphoid tissues at the interface of self and microbiota

(2009) G Eberl et al.   Mucosal Immunology

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development

(2009) Duncan M Gascoyne et al.   NATURE IMMUNOLOGY

Unique subset of natural killer cells develops from progenitors in lymph node

(2008) L. L. Veinotte et al.   BLOOD

Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut

(2008) Masayuki Tsuji et al.   IMMUNITY

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage

(2008) Adam K. Savage et al.   IMMUNITY

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

(2008) Carmelo Luci et al.   NATURE IMMUNOLOGY

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue–inducer cells with stroma of the T cell zone

(2008) Elke Scandella et al.   NATURE IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE