The hematopoietic stem cell diet

Glutaminolysis is a metabolic dependency in FLT3ITDacute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

(2018) Paolo Gallipoli et al.   BLOOD

Branched-chain amino acid metabolism in cancer

(2018) Elitsa A. Ananieva et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

mTOR signaling in stem and progenitor cells

(2018) Delong Meng et al.   DEVELOPMENT

High fat diet-induced obesity exacerbates hematopoiesis deficiency and cytopenia caused by 5-fluorouracil via peroxisome proliferator-activated receptor γ

(2018) Yanhong Li et al.   EXPERIMENTAL HEMATOLOGY

Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

(2018) Bin Guo et al.   NATURE MEDICINE

Lifelong dietary intervention does not affect hematopoietic stem cell function

(2017) Seka Lazare et al.   EXPERIMENTAL HEMATOLOGY

Role of mTORC1–S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia

(2017) Joydeep Ghosh et al.   EXPERIMENTAL HEMATOLOGY

Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions

(2017) Daiki Karigane et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy

(2017) Hideyuki Oguro et al.   JOURNAL OF CLINICAL INVESTIGATION

Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells

(2017) Demetrios Kalaitzidis et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

(2017) Elena Ansó et al.   NATURE CELL BIOLOGY

Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche

(2017) Allison L. Boyd et al.   NATURE CELL BIOLOGY

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

HSC Niche Biology and HSC Expansion Ex Vivo

(2017) Sachin Kumar et al.   TRENDS IN MOLECULAR MEDICINE

Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity

(2017) Adam C. Wilkinson et al.   Cell Systems

Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis

(2016) Chiaki Iwamura et al.   BLOOD

Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

(2016) Kamilla S. Josefsdottir et al.   BLOOD

Enhancing Stem Cell Transplantation with “Nutri-technology”

(2016) Valter D. Longo et al.   Cell Stem Cell

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow

(2016) Susan M. van den Berg et al.   FASEB JOURNAL

New agents in HSC mobilization

(2016) Mélanie J. Domingues et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

(2016) Larry L. Luchsinger et al.   NATURE

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation

(2016) Zhigang Lu et al.   NATURE MEDICINE

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

(2016) K. Ito et al.   SCIENCE

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

(2016) Y. Taya et al.   SCIENCE

Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production

(2016) Mauricio Cortes et al.   Cell Reports

The healthy human microbiome

(2016) Jason Lloyd-Price et al.   Genome Medicine

Making sense of hematopoietic stem cell niches

(2015) P. E. Boulais et al.   BLOOD

Hematopoietic stem cells: concepts, definitions, and the new reality

(2015) C. J. Eaves   BLOOD

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche

(2015) Yubin Luo et al.   Cell Metabolism

Autophagy regulates the cell cycle of murine HSPCs in a nutrient-dependent manner

(2015) Yan Cao et al.   EXPERIMENTAL HEMATOLOGY

Vitamin D Control of Hematopoietic Cell Differentiation and Leukemia

(2015) George P. Studzinski et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

(2014) Chia-Wei Cheng et al.   Cell Stem Cell

Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification

(2014) Leal Oburoglu et al.   Cell Stem Cell

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

(2014) Kanakadurga Singer et al.   Molecular Metabolism

Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells

(2013) Ryo Yamamoto et al.   CELL

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Cell cycle regulation in hematopoietic stem cells

(2011) Eric M. Pietras et al.   JOURNAL OF CELL BIOLOGY

Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function

(2011) F. Ferraro et al.   Science Translational Medicine

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE