Article
Chemistry, Analytical
Shanshan Jia, Shao Chang, Lin Zhang, Zhengwei Gui, Linhui Liu, Zhenglan Ma, Shuyu Li, Xingchen Huang, Hongying Zhong
Summary: A photocatalytic technique has been developed for in situ mass spectrometric identification and spatial imaging of positional isomers of lipids. It involves the use of gold nanowires to transfer plasmonic hot electrons, generating hydroxyl radicals that cause bond cleavages. The technique can determine the locations of C=C bonds through diagnostic fragment ions produced by collision or auto-fragmentation.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Waseem K. Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Kenneth J. Rhodes, Vikram Khurana, Robert H. Scannevin, Chee Yeun Chung
Summary: Currently, there is no preventive or disease-modifying therapy available for Parkinson's Disease (PD). The failure of clinical trials calls for a re-evaluation of pre-clinical models that better replicate disease mechanisms and predict clinical outcomes. Patient-derived induced pluripotent stem cell (iPSC) models have recently emerged as attractive options to mimic disease-relevant neuropathology in vitro without artificially overexpressing disease-related proteins. In this study, iPSCs derived from early-onset PD patients with specific mutations were utilized to generate a three-dimensional cortical neurosphere model. The model showed alterations in fatty acid profiles and increased levels of pathogenic proteins, which could be attenuated by a small molecule inhibitor. These findings suggest that the 3D cortical neurosphere model is a useful tool for investigating PD and testing potential therapeutics.
Article
Biochemistry & Molecular Biology
Bing-Yen Wang, Yuan-Yen Chang, Li-Yen Shiu, Yi-Ju Lee, Yu-Wei Lin, Yu-Shen Hsu, Hsin-Ting Tsai, Sung-Po Hsu, Li-Jen Su, Meng-Hsiu Tsai, Jing-Hong Xiao, Jer-An Lin, Chang-Han Chen
Summary: This study systematically investigated the expression patterns and clinical outcomes of SCD1 in multiple human cancers and found that SCD1 is dysregulated in several types of cancers and acts as a diagnostic biomarker. Using ESCC as an example, it was found that SCD1 is upregulated in ESCC tumor tissues and is associated with clinicopathological characteristics and poor survival outcomes. Additionally, the study revealed the potential therapeutic target of the miR-181a-5p/SCD1 axis for ESCC treatment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Agronomy
Piera Iommelli, Federico Infascelli, Nadia Musco, Micaela Grossi, Maria Ferrara, Fiorella Sarubbi, Biagio D'Aniello, Pietro Lombardi, Raffaella Tudisco
Summary: This study compared the effects of two different diets on buffalo meat quality and SCD gene expression in adipose tissue, revealing important differences between buffalo and bovine species, highlighting the need for specific research on buffalo.
Article
Biochemistry & Molecular Biology
Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng, Jerome Baudry
Summary: SCD1 is a key metabolic protein involved in converting saturated fatty acids to monounsaturated fatty acids, with overactivity linked to diseases. Computational molecular dynamics study reveals interactions between SCD1, substrates, and products, providing insights for drug discovery.
Article
Multidisciplinary Sciences
Reyhaneh Sefidabi, Alireza Alizadeh, Sadaf Alipour, Ramesh Omranipour, Maryam Shahhoseini, Amin Izadi, Samira Vesali, Ashraf Moini
Summary: This study compared the FA profiles, desaturase index, and SCD1 mRNA levels in the adipose tissue surrounding tumors in women with breast cancer and benign breast disease. The results showed significantly higher mRNA levels of SCD1 in the breast adipose tissue of breast cancer patients compared to benign breast disease patients.
Article
Cell Biology
Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui, Xubin Li, Maga Sanchez, Zeynep Dereli, Nermin Kahraman, Goknur Kara, Xiaohua Chen, Caishang Zheng, Daniel McGrail, Nidhi Sahni, Yiling Lu, Ozgun Babur, Murat Cokol, Bora Lim, Bulent Ozpolat, Chris Sander, Gordon B. Mills, Anil Korkut
Summary: This study suggests that targeting MCL1 and BET may have therapeutic potential for the treatment of basal-like breast cancers. BET inhibition induces an adaptive response leading to the evasion of apoptosis in breast cancer cells driven by MCL1 protein. The mechanism involves upregulation of lipid synthesis enzymes, which affects cell motility and membrane fluidity, as well as the activation of HER2/EGFR signaling. MCL1 copy-number alterations are associated with the effectiveness of BET and MCL1 co-targeting.
Article
Pharmacology & Pharmacy
Cheng Chen, Xin Xin, Qian Liu, Hua-Jie Tian, Jing-Hua Peng, Yu Zhao, Yi-Yang Hu, Qin Feng
Summary: The study demonstrates that the GC combination has a significant anti-lipogenesis effect on NAFLD, improving symptoms by inhibiting hepatic SCD-1 and the DNL process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Anna Pacwa, Joanna Machowicz, Alicja Wojtyniak, Marita Pietrucha-Dutczak, Elisa Toropainen, Ali Koskela, Ewa Mrukwa-Kominek, Joanna Lewin-Kowalik, Adrian Smedowski
Summary: The study evaluated the effect of SCD1 inhibitor MF-438 on the differentiation of monocytes exposed to eye drop detergents. The results showed a strong correlation between SCD1 concentration and macrophage count in the culture.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Oncology
M. H. Wang, Y. Ye, M. Zhang, B. R. Zhou, J. N. Wang, Y. N. Song, W. Xia
Summary: Anaplastic thyroid carcinoma (ATC) is a highly aggressive cancer, and the study shows that exosomes loaded with SCD-1 siRNA can inhibit ATC cell proliferation and promote apoptosis. This provides a promising therapeutic strategy for ATC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yueqing Xue, Liangyu Lin, Qing Li, Keli Liu, Mingyuan Hu, Jiayin Ye, Jianchang Cao, Jingjie Zhai, Fanjun Zheng, Yu Wang, Tao Zhang, Liming Du, Cheng Gao, Guan Wang, Xuefeng Wang, Jun Qin, Xinhua Liao, Xiangyin Kong, Lydia Sorokin, Yufang Shi, Ying Wang
Summary: The role of fatty acid desaturation catabolized by SCD1 in regulating hair follicle stem cells and hair growth has been discovered. The absence of SCD1 leads to abnormal hair growth, affecting the appearance and quality of hair.
Article
Biochemistry & Molecular Biology
Richard W. J. Helder, Jannik Rousel, Walter A. Boiten, Gerrit S. Gooris, Andreea Nadaban, Abdoelwaheb El Ghalbzouri, Joke A. Bouwstra
Summary: Full thickness models (FTM) closely resemble native human skin (NHS) but have reduced barrier function due to deviations in lipid composition, particularly an increase in monounsaturated lipids. In this study, inhibiting stearoyl-CoA desaturase-1 (SCD-1) successfully improved lipid composition in FTMs, leading to better mimicry of NHS lipid composition. This approach may help optimize FTMs for future studies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Acoustics
Chenchen Zhang, Jinfeng Wang, Jing Xie
Summary: This study investigated the effects of various ultrasonic treatments on the quality of large yellow croaker during cold storage at 4°C. The results showed that dual frequency ultrasound had better antibacterial effects compared to single frequency ultrasound. Group D had a significant impact on preserving the overall sample quality.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Veera Raghavan Thangapandi, Oskar Knittelfelder, Mario Brosch, Eleonora Patsenker, Olga Vvedenskaya, Stephan Buch, Sebastian Hinz, Alexander Hendricks, Marina Nati, Alexander Herrmann, Devavrat Ravindra Rekhade, Thomas Berg, Madlen Matz-Soja, Klaus Huse, Edda Klipp, Josch K. Pauling, Judith A. H. Wodke, Jacobo Miranda Ackerman, Malte von Bonin, Elmar Aigner, Christian Datz, Witigo von Schoenfels, Sophie Nehring, Sebastian Zeissig, Christoph Roecken, Andreas Dahl, Triantafyllos Chavakis, Felix Stickel, Andrej Shevchenko, Clemens Schafmayer, Jochen Hampe, Pallavi Subramanian
Summary: The rs641738C>T variant near the MBOAT7 locus is associated with liver fibrosis in various liver diseases. Mice with Mboat7 deficiency and human carriers of rs641738TT with fibrosis showed alterations in lipid signaling, suggesting a potential targetable treatment option for NAFLD.
Article
Biotechnology & Applied Microbiology
John Roger Otto, Shedrach Benjamin Pewan, Richard Crawford Edmunds, Felista Waithira Mwangi, Robert Tumwesigye Kinobe, Oyelola Abdulwasiu Adegboye, Aduli Enoch Othniel Malau-Aduli
Summary: This study investigated the expression of lipogenic genes and their correlation with fatty acids in the ribeye muscle of Tattykeel Australian White (TAW) lambs. The results showed that FABP4 and FASN genes play an important role in the biosynthesis of fatty acids in the muscle, and diet composition has an influence on their expressions.
Article
Fisheries
Baosuo Liu, Caigang Tan, Dongling Zhang, Mingqiang Chen, Zhikai Niu, Guiju Huang, Youning Li, Tianshi Zhang, Dahui Yu
AQUACULTURE RESEARCH
(2017)
Article
Fisheries
Zihao Meng, Bo Zhang, Baosuo Liu, Haimei Li, Sigang Fan, Dahui Yu
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Fisheries
Jinfen Wei, Sigang Fan, Baosuo Liu, Bo Zhang, Jiaqi Su, Dahui Yu
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Fisheries
Jinfen Wei, Baosuo Liu, Sigang Fan, Bo Zhang, Jiaqi Su, Dahui Yu
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Fisheries
Guiju Huang, Xiaomin Bi, Bo Zhang, Tao Qu, Baosuo Liu, Sigang Fan, Dahui Yu
JOURNAL OF SHELLFISH RESEARCH
(2017)
Article
Biotechnology & Applied Microbiology
Haimei Li, Bo Zhang, Sigang Fan, Baosuo Liu, Jiaqi Su, Dahui Yu
MARINE BIOTECHNOLOGY
(2017)
Article
Agriculture, Dairy & Animal Science
Sigang Fan, Zhenzhen Wang, Dahui Yu, Youhou Xu
JOURNAL OF APPLIED ANIMAL RESEARCH
(2018)
Article
Zoology
Bo Zhang, Changbo Zhu, Zihao Meng, Baosuo Liu, Lian Zhong, Guiju Huang, Jiaqi Su, Sigang Fan, Dahui Yu
PAKISTAN JOURNAL OF ZOOLOGY
(2019)
Article
Fisheries
Lirong Bai, Zihao Meng, Baosuo Liu, Deguo Yang, Dahui Yu
AQUACULTURE RESEARCH
(2020)
Article
Fisheries
Jian Chen, Zhenghua Deng, Haijun Wei, Wang Zhao, Mingqiang Chen, Gang Yu, Jing Sun, Dahui Yu, Youning Li, Yu Wang, Lirong Bai
Summary: By comparing the sperm morphology, egg size, and D-shaped larvae size of four different clam species, it was found that there are significant differences in these aspects, providing important information for the classification and breeding of these species.
TURKISH JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2021)
Article
Fisheries
Jian Chen, Hui Luo, Ziqin Zhai, Hongchen Wang, Baosuo Liu, Lirong Bai, Dahui Yu
Summary: The study explored genetic improvement strategies for pearl oysters by conducting a full 3 x 3 diallel cross of three local strains. Results showed varying additive genetic effects among the strains, significant heterotic outcomes for all growth traits, and a high correlation between strain additive performance and total performance for growth traits. These findings indicate the potential to use strain additive variation for improving P. fucata cultivation in China.
AQUACULTURE INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Jian Chen, Ziqin Zhai, Lili Lu, Suping Li, Dan Guo, Lirong Bai, Dahui Yu
Summary: In this study, the miRNA and mRNA transcriptomics of different developmental stages of the pearl oyster were analyzed using RNA sequencing. The researchers identified 329 miRNAs and 33,550 unigenes and found differentially expressed genes and miRNAs involved in larval development. Real-time PCR was used to validate the expression of some of these genes and miRNAs. This study provides valuable insights into the regulatory mechanisms of miRNA in invertebrate larval development.
MARINE BIOTECHNOLOGY
(2022)
Article
Fisheries
Lirong Bai, Suping Li, Pei Wang, Ying Guo, Yusi Zheng, Jiaqing He, Dan Li, Jicui He, Yeshao Peng, Dahui Yu
Summary: This study identified a TLR13 gene in the pearl oyster for the first time. The expression of PfTLR13 was found to be highest in the gills and was upregulated in response to exposure to Vibrio alginolyticus or pathogen-associated molecular patterns. The immune response to the first stimulation was weaker, indicating a potential immune priming mechanism in pearl oysters similar to acquired immunity in vertebrates.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sigang Fan, Daizhi Zhou, Youhou Xu, Dahui Yu
JOURNAL OF APPLIED ANIMAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Haimei Li, Deqing Wang, Zhenghua Deng, Guiju Huang, Sigang Fan, Daizhi Zhou, Baosuo Liu, Bo Zhang, Dahui Yu
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2017)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.