Review
Pharmacology & Pharmacy
Huanhuan Pang, Zeping Hu
Summary: Emerging evidence has shown the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of metabolism in biological systems. With advanced analytical techniques, metabolomics has significant value in basic drug research, including understanding disease mechanisms and identifying drug targets.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Pharmacology & Pharmacy
Komal Sharma, Krishna K. Sharma, Anku Sharma, Rahul Jain
Summary: The development of peptide therapeutics from reaction vessels to life-saving drugs has been fascinating. Advances in peptide chemistry techniques have contributed to the progress, including microwave irradiation, ligation chemistry, recombinant synthesis, and integration with metal catalysis. Emerging technologies, such as DNA-encoded libraries and display techniques, are changing the landscape of peptide drug discovery. This review analyzes FDA-approved peptide drugs and those in clinical trials, highlighting recent advances in peptide-based drug discovery.
DRUG DISCOVERY TODAY
(2023)
Review
Chemistry, Analytical
Kwang-Ho Lee, Tae-Hyung Kim
Summary: The article discusses the widespread use of multicellular tumor spheroids (MCTs) in the biomedical field and their connection to drug screening, emphasizing the importance of mimicking the tumor microenvironment for understanding cell-cell and cell-matrix interactions.
Review
Pharmacology & Pharmacy
Juan Carlos Alarcon-Barrera, Sarantos Kostidis, Alejandro Ondo-Mendez, Martin Giera
Summary: Metabolomics has now become an accepted and widely applied approach in early drug development in the pharmaceutical industry. It has evolved from a pure exploratory tool to a more mature and quantitative biochemical technology. Metabolomics analysis helps in defining physiological response, target engagement markers, and elucidating the mode of action of drug candidates under investigation.
DRUG DISCOVERY TODAY
(2022)
Article
Oncology
Sergey G. Klochkov, Margarita E. Neganova, Vladimir N. Nikolenko, Kuo Chen, Siva G. Somasundaram, Cecil E. Kirkland, Gjumrakch Aliev
Summary: The use of nanoparticles in anticancer drugs improves safety and efficacy, with advantages such as effective targeting, delayed release, increased half-life, and reduced systemic toxicity. Nano-carriers have shown significant improvements in drug delivery compared to traditional administration, but there are still limitations in their clinical use.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Samuel Herianto, Boopathi Subramani, Bo-Ruei Chen, Chien-Sheng Chen
Summary: Protein-lipid interactions are crucial in various cellular processes. Liposomes are widely used to study these interactions, but their applications in high-throughput methods need further exploration. This article summarizes the development of liposomes in low and high-throughput methods and provides constructive comments for future advancements.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2022)
Review
Chemistry, Medicinal
Jian Song, Mingzheng Hu, Jun Zhou, Songbo Xie, Tianliang Li, Yan Li
Summary: Targeted protein degradation (TPD) is a promising therapeutic approach that offers advantages over traditional inhibitors. This method relies on cell self-degradation mechanisms and can be used to target dysregulated proteins. Various TPD strategies have been developed and show potential for drug discovery.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Yurong Lai, Xiaoyan Chu, Li Di, Wei Gao, Yingying Guo, Xingrong Liu, Chuang Lu, Jialin Mao, Hong Shen, Huaping Tang, Cindy Q. Xia, Lei Zhang, Xinxin Ding
Summary: Drug metabolism and pharmacokinetics is an important branch of pharmaceutical sciences that has evolved from descriptive to quantitative and mechanistic understanding of drug candidates. Progress has been made in characterizing physiochemical properties of drugs, minimizing drug-drug interaction potentials and recognizing the importance of membrane transporters. Investments in new modalities have led to further innovations in bioanalytical tools.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Biochemistry & Molecular Biology
Lin He, Chuxia Deng
Summary: Organotypic tissue slice culture has numerous advantages in anticancer drug development, including the preservation of cell repertoire, quick assessment of therapeutic efficacy, and the ability to select personalized treatment regimens. It is expected to become a potent platform for individualized drug screening.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Mina Shahmohammadi, Rajib Mukherjee, Cortino Sukotjo, Urmila M. Diwekar, Christos G. Takoudis
Summary: This review presents the recent computational advances in thermal ALD and discusses how theoretical methods can enhance the efficiency of experiments.
Review
Green & Sustainable Science & Technology
Henna Mohi ud din Wani, Chiu-Wen Chen, Chun-Yung Huang, Reeta Rani Singhania, Young Joon Sung, Cheng-Di Dong, Anil Kumar Patel
Summary: Bioactive peptides derived from proteinaceous red algae biomass have attracted significant attention for their varied structures and potential applications. However, there is a lack of research on feasible approaches for producing and purifying bioactive peptides. This article explores the latest trends in easily applicable approaches for extracting bioactive peptides for cutaneous applications. It also emphasizes the importance of peptide purity and bioactivity, and suggests future research directions to increase yield and improve separation methods, as well as conducting human clinical trials to validate their health benefits.
Review
Energy & Fuels
Sigeng Chen, Haixia Zhang, Chuangang Yao, Hao Lou, Mingcun Chen, Xiaoshi Lang, Kedi Cai
Summary: Surface modification techniques, such as solution infiltration, atomic layer deposition (ALD), and one-pot method, have been employed to improve the catalytic activity and durability of solid oxide fuel cell (SOFC) cathodes. These techniques have shown significant achievements in enhancing performance. This review provides an overview of the principles, recent progress, advantages, disadvantages, challenges, and prospects of these advanced surface modification technologies, offering valuable guidance and potential directions for the commercialization of SOFC technology.
Review
Chemistry, Analytical
Yufeng Jiao, Liyang Gao, Yaru Ji, Wu Liu
Summary: Single-cell analysis (SCA) is a powerful tool in drug development, allowing the detection of cellular heterogeneity and providing unique insights into complex biological processes. It has been widely used to uncover the origin of drug resistance, identify new drug targets, accelerate drug screening, and predict drug response.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Cheng Shi, Ziting Zhou, Xiaowei Chi, Siyu Xiu, Chuxiao Yi, Ziqiong Jiang, Ruyi Chen, Liangren Zhang, Zhenming Liu
Summary: Gout is an autoinflammatory disease caused by the deposition of urate crystals. There is currently no effective cure method for gout, but research on gout treatment drugs is progressing. This review provides a landscape view of the current state of research on gout treatment drugs, including anti-inflammatory and analgesic drugs, drugs that promote uric acid excretion, and drugs that inhibit uric acid production.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Alexandra Pusta, Mihaela Tertis, Izabell Craciunescu, Rodica Turcu, Simona Mirel, Cecilia Cristea
Summary: This review provides a critical overview of recent advancements in the use of magnetic nanoparticles in drug delivery, including their classification, characteristics, synthesis and functionalization methods, limitations, and examples of magnetic drug delivery systems incorporating chemotherapeutics or RNA.
Review
Instruments & Instrumentation
Nidhi Aggarwal, Sachin, Bushra Nabi, Sumit Aggarwal, Sanjula Baboota, Javed Ali
Summary: Despite the benefits of HAART for AIDS patients, managing HIV infections remains a global health challenge. The inability of ARV drugs to cross the BBB has limited their effectiveness, but nano-based drug delivery strategies have shown promise in improving drug penetration and targeting viral reservoirs in the brain, offering a potential solution for treating NeuroAIDS.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Polymer Science
Annu, Sanjula Baboota, Javed Ali
Summary: The study successfully optimized chitosan nanoparticles for nasal delivery to enhance the bioavailability of lurasidone hydrochloride, showing potential in improving drug release and nasal permeation.
Article
Instruments & Instrumentation
Tausif Alam, Mohd Asif Ansari, Sanjula Baboota, Javed Ali
Summary: The study successfully improved the oral bioavailability of isradipine through optimizing the formulation of nanostructured lipid carriers, presenting a promising strategy for long-term management of hypertension. Additionally, the nanostructured lipid carrier of isradipine demonstrated effective cardioprotection in a rat model of myocardial infarction.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Ajay Singh, Zeba Maqsood, Mohammad Kashif Iqubal, Javed Ali, Sanjula Baboota
Summary: Wound healing is a complex process that involves the restoration of injured tissue. Nanocarriers have shown promising results in accelerating wound healing.
CURRENT DRUG DELIVERY
(2022)
Article
Biochemical Research Methods
Dheeraj Kataria, Ameeduzzafar Zafar, Javed Ali, Karishma Khatoon, Saba Khan, Syed Sarim Imam, Mohd Yasir, Asgar Ali
Summary: The optimized nanostructured lipid carriers (NLCs) of the antihypertensive drug lacidipine (LAC) showed nanometric size, high entrapment efficiency, and drug loading, leading to significantly improved drug release and intestinal permeation, ultimately resulting in higher oral bioavailability and antihypertensive effect compared to LAC-dispersion.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
(2022)
Review
Pharmacology & Pharmacy
Shaheen Parveen, Musheer Ahmed, Sanjula Baboota, Javed Ali
Summary: This review provides a comprehensive overview of the pathophysiology, epidemiology, types, causes, diagnosis, and topical treatment options for psoriasis, as well as the role of nanotechnology-based delivery systems in psoriasis management.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Chemistry, Inorganic & Nuclear
Happy Garg, Saurabh Mittal, Muhammad Usama Ashhar, Shobhit Kumar, Shweta Dang, Kuldeep Nigam, Javed Ali, Sanjula Baboota
Summary: The study developed paroxetine-loaded SNEDDS to increase oral bioavailability. Optimized SNEDDS exhibited good particle morphology and transmittance. Results from permeability and behavioral studies demonstrated the enhanced therapeutic effects of paroxetine-loaded SNEDDS. Pharmacokinetic studies showed higher oral bioavailability of paroxetine SNEDDS.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Sabna Kotta, Abdul Wadood Khan, Shahid H. Ansari, Rakesh Kumar Sharma, Y. T. Kamal, Hibah Mubarak Aldawsari, Nabil Abdulhafiz Alhakamy, Sanjula Baboota, Javed Ali
Summary: The development of a nanoemulsion formulation of efavirenz has shown promising results in improving drug permeability and bioavailability, addressing the challenges of inaccurate dosing in pediatric antiretroviral therapy for HIV infection. The formulation has demonstrated an effective dose adjustable formulation for HIV therapy, especially in pediatric population.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Saurabh Mittal, Javed Ali, Sanjula Baboota
Summary: Temozolomide and resveratrol have synergistic effects in treating glioblastoma, and a newly developed HPLC method allows for simultaneous assessment of both compounds with high precision and accuracy.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Farheen Fatima Qizilbash, Muhammad Usama Ashhar, Ameeduzzafar Zafar, Zufika Qamar, Annu, Javed Ali, Sanjula Baboota, Mohammed M. Ghoneim, Sultan Alshehri, Asgar Ali
Summary: In this study, a thymoquinone-enriched naringenin-loaded nanostructured lipid carrier was developed for nasal delivery in the treatment of depression. The optimized carrier exhibited excellent drug release and permeation properties, leading to improved therapeutic effect compared to traditional suspension and marketed formulation.
Article
Pharmacology & Pharmacy
Ali Sartaj, Annu, Meraj Alam, Largee Biswas, Mohammad Shahar Yar, Showkat Rasool Mir, Anita Kamra Verma, Sanjula Baboota, Javed Ali
Summary: This research investigated the potential of dual drug-loaded nanostructure lipidic carriers (NLCs) of green tea extract and Ribociclib in the treatment of breast cancer. In vitro and in vivo studies were conducted to evaluate the drug release, bioavailability, and therapeutic efficacy of the prepared NLCs. The results demonstrated controlled drug release, increased bioavailability, and promising therapeutic potential.
JOURNAL OF DRUG TARGETING
(2022)
Editorial Material
Pharmacology & Pharmacy
Marcio Rodrigues, Javed Ali, Gilberto Alves
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nupur Shrivastava, Ankit Parikh, Rikeshwer Prasad Dewangan, Largee Biswas, Anita Kamra Verma, Saurabh Mittal, Javed Ali, Sanjay Garg, Sanjula Baboota
Summary: The optimized solid self-nanoemulsifying drug delivery system shows promising anti-cancer effects and significantly improves drug bioavailability and therapeutic efficacy.
Review
Psychology, Multidisciplinary
Syed Hamid Hussain Madni, Javed Ali, Hafiz Ali Husnain, Maidul Hasan Masum, Saad Mustafa, Junaid Shuja, Mohammed Maray, Samira Hosseini
Summary: This research investigates the factors influencing the adoption of IoT in E-Learning in higher educational institutes in developing countries. A proposed adoption model categorizes the influencing factors into four groups: individual, organizational, environmental, and technological. The significant factors identified include privacy, infrastructure readiness, financial constraints, ease of use, support of faculty, interaction, attitude, and network and data security.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohammad Kashif Iqubal, Harsimran Kaur, Shadab Md, Nabil A. Alhakamy, Ashif Iqubal, Javed Ali, Sanjula Baboota
Summary: This article discusses the importance and advantages of using nanocarrier fabricated combinatorial drug delivery systems in different types of cancer as a future anticancer treatment approach. It highlights the potential of personalized combinatorial theranostic medicine in improving clinical outcomes.