Are systematic reviews and meta-analyses still useful research? We are not sure

The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta-analyses

(2016) JOHN P.A. IOANNIDIS   MILBANK QUARTERLY

Registration and design alterations of clinical trials in critical care: a cross-sectional observational study

(2014) Vijay Anand et al.   INTENSIVE CARE MEDICINE

How to Read a Systematic Review and Meta-analysis and Apply the Results to Patient Care

(2014) Mohammad Hassan Murad et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Accumulating Research: A Systematic Account of How Cumulative Meta-Analyses Would Have Provided Knowledge, Improved Health, Reduced Harm and Saved Resources

(2014) Mike Clarke et al.   PLoS One

Establishing a Successful Clinical Research Program

(2014) Daniele Scoglio et al.   Clinics in Colon and Rectal Surgery

Influence of Reported Study Design Characteristics on Intervention Effect Estimates From Randomized, Controlled Trials

(2013) Jelena Savović et al.   ANNALS OF INTERNAL MEDICINE

Demystifying trial networks and network meta-analysis

(2013) E. J. Mills et al.   BMJ-British Medical Journal

GRADE guidelines: 3. Rating the quality of evidence

(2011) Howard Balshem et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study

(2011) Kristian Thorlund et al.   PLoS One

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

(2008) Gordon H Guyatt et al.   BMJ-British Medical Journal

Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis

(2007) Jørn Wetterslev et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY