Article
Cell Biology
Ricardo J. Antonia, Eveliina Karelehto, Kan Toriguchi, Mary Matli, Robert S. Warren, Lawrence M. Pfeffer, David B. Donner
Summary: The study reveals that TNF activates STAT3, which in turn regulates the expression of inflammatory chemokines. Furthermore, Tnfaip3/A20 is identified as a downstream target of STAT3, and it functions to restrict TNF-induced inflammation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Yu Zhen Tang, Ying Liu, Ya Ping Chen, Ting Ting Feng, Ya Yi Liu, Yan Wang, Jun Ping Zhang, Wei Heng Xu
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease, and citropten, as a compound, shows potential in treating IBD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sirinada Inthanon, Pornngarm Dejkriengkraikul, Supachai Yodkeeree
Summary: This study found that notopterol can inhibit the IL-17-induced proliferation and invasion of A549 lung adenocarcinoma cells by suppressing the activation of the MAPK, Akt, STAT3, AP-1, and NF-kappa B signaling pathways, as well as modulating EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Min Deng, Xi Wu, Xiaoyue Duan, Jiuzhi Xu, Xu Yang, Xiaole Sheng, Pengbo Lou, Chunlei Shao, Cong Lv, Zhengquan Yu
Summary: The study showed that the probiotic Lactobacillus paracasei L9 can alleviate the development of DSS-induced colitis by enhancing the abundance of butyrate-producing bacterial strains. The mechanism involves butyrate suppressing the IL-6/STAT3 signaling pathway to ameliorate inflammatory responses in colitis. This provides new insight into a potential therapeutic target for IBD remission.
Article
Integrative & Complementary Medicine
Yishan Zhou, Shuangli Xiang, Haoyi Zheng, Ying Hou, Ying Wang, Chuang-Chuang Li, Qin Wu, Jingshan Shi, Xiuping Chen
Summary: The inhibitory effect of neferine on colitis-associated colorectal cancer was investigated, revealing its potential role in regulating NF-kappa B and STAT3 signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Dermatology
Mohammad Shahidi Dadras, Azadeh Rakhshan, Sahar Dadkhahfar, Tara Barat
Summary: The study compared IL-17 positive cell counts in LPP and DLE patients, finding significantly higher levels in both groups compared to controls, with LPP having higher IL-17 levels. Using immunohistochemistry to detect IL-17 positive cells can effectively distinguish between LPP and DLE.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xinyue Yang, Qing Wang, Xinghai Zhang, Lingling Li, Xingyue Cao, Li Zhou, Yefei Huang, Guixiang Sun, Yansu Chen
Summary: Purple yam polyphenol extracts (PYPE) can improve ulcerative colitis and inhibit colitis-related colorectal cancer in mice models by exerting anti-inflammatory and anticancer effects, suggesting it as a potential preventive strategy against UC and CAC.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
E. C. Mooney, S. E. Sahingur
Summary: Inflammation is triggered by innate sensors, and immune cell activation is a strictly regulated process supported by negative feedback mechanisms. Ubiquitination plays a critical role in regulating the immune system, with A20 serving as an important ubiquitin-editing enzyme in inflammation.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Cell Biology
Qi-qi Liu, Wei-wei Wu, Jian Yang, Rui-bin Wang, Ling-ling Yuan, Pei-zhao Peng, Mao-yun Zeng, Ke Yu
Summary: In this study, the GP130-targeting molecule LMT-28 was found to effectively reduce lipopolysaccharide-induced bone resorption around implants in diabetic rats. LMT-28 downregulated the expression of RANKL and decreased osteoclast activity through the JAK2/STAT3 signaling pathway. These findings highlight the potential of LMT-28 as a therapeutic agent for peri-implantitis in diabetic patients.
MEDIATORS OF INFLAMMATION
(2023)
Article
Immunology
Hong-Ji Deng, QuZhen Deji, WangDui Zhaba, Jia-Qiang Liu, Sheng-Qing Gao, Yan-Ling Han, Meng-Liang Zhou, Chun-Xi Wang
Summary: The study showed that A20 can attenuate early brain injury after SAH by suppressing the NF-kappa B pathway and reducing inflammatory responses, thereby exerting neuroprotective effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yinuo Gu, Alan Chen-Yu Hsu, Xu Zuo, Xiaoping Guo, Zhengjie Zhou, Shengyu Jiang, Zhuoer Ouyang, Fang Wang
Summary: In this study, it was found that A20 acts as a crucial molecular switch to dampen the inflammatory responses caused by IAV infection. Chronic exposure to low-dose LPS can restrict excessive inflammation by increasing A20 expression. A20 and its induced PPAR-alpha and -gamma play a key role in suppressing excessive inflammatory responses in the chronic low-dose LPS environment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Xuedi Gao, Wenfang Bao, Jin Bai, Kailing Fan, Li Li, Yandong Li
Summary: UHMK1 is frequently upregulated in colorectal cancer and its high expression predicts poor prognosis. Knockdown of UHMK1 inhibits CRC cell proliferation and increases sensitivity to oxaliplatin, while overexpression of UHMK1 promotes CRC cell growth and oxaliplatin resistance. UHMK1 interacts with STAT3 and enhances its activity in regulating gene transcription, thus affecting IL6/STAT3 signaling.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Yamin Lu, Chenhao Xing, Cuigai Zhang, Xiuqin Lv, Guangxia Liu, Fang Chen, Zhan Hou, Donghui Zhang
Summary: This study investigated the changes and correlations among IL-17, NF-kappa B, IL-6, IL-10, interferon-gamma (IFN-gamma), TNF-alpha, IL-2 and IL-4 in patients with different autoimmune thyroid diseases in order to further clarify the pathogenesis of autoimmune thyroid disease.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Cell Biology
Shasha Liu, Siya Liu, Ziding Yu, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, Jinxuan Hong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang, Ji-Long Chen
Summary: This study reveals that early-stage infection with various viruses, including influenza A virus, leads to IL-6-independent phosphorylation of STAT3 Y705, which is critical for antiviral immunity. Knockin mice with STAT3Y705F/1 mutation show suppressed antiviral response, lung tissue injury, and poor survival upon IAV infection. The phosphorylation of STAT3 Y705 restrains IAV pathogenesis by repressing excessive IFN production, and blocking the phosphorylation enhances IFN expression and potentiates IAV virulence in mice. Knockout of IFNAR1 or IFNLR1 in STAT3Y705F/1 mice protects them from lung injury and reduces viral load.
Article
Biotechnology & Applied Microbiology
Huyi Lei, Yongyong Ma, Jie Tan, Qifa Liu
Summary: HP can accelerate megakaryocyte apoptosis to promote platelet destruction in ITP mice, possibly through the activation of the NF-kappa B/IL-17 pathway.
ONCOTARGETS AND THERAPY
(2021)
Article
Polymer Science
Jewon Choi, Seyoung Kim, Huy Ju Mun, Jin Yoo, Soo-Hyung Choi, Kookheon Char
Summary: ABC triblock copolymer hydrogels with hydrophobic cores and supramolecular junctions exhibit multifunctional antifreeze properties, making them potentially valuable for cryo-preservable and bio-injectable drug storage and delivery.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Polymer Science
Sanghoon Song, Yohan Chang, Seung-Hwan Oh, Soyoon Kim, Seungsoo Choi, Seyoung Kim, Jin-Kyun Lee, Soo-Hyung Choi, Jeewoo Lim
Summary: We developed a method for the synthesis of heavily fluorinated polynorbornenes through fluoropolymer dispersion ring-opening metathesis polymerization. The use of a fluorinated block copolymer as a stabilizer enabled complete monomer conversion within minutes, resulting in fluorous polynorbornenes with predetermined molecular weights and low molecular weight distributions.
Article
Energy & Fuels
Laidong Zhou, Tong-Tong Zuo, Chun Yuen Kwok, Se Young Kim, Abdeljalil Assoud, Qiang Zhang, Juergen Janek, Linda F. Nazar
Summary: A series of new lithium mixed-metal chlorospinels are reported as solid electrolytes for all-solid-state lithium batteries, which exhibit high ionic conductivity and low electronic conductivity, showing potential for high-performance all-solid-state lithium batteries.
Article
Biochemistry & Molecular Biology
Seyoung Kim, Daniel J. Fesenmeier, Sungwan Park, Sandra E. Torregrosa-Allen, Bennett D. Elzey, You-Yeon Won
Summary: This study investigates the clearance pathways and kinetics of amphiphilic poly(styrene-block-ethylene glycol) (PS-PEG) nanoparticles in the lungs. The results demonstrate that PS-PEG nanoparticles have a prolonged retention time in the lungs and are cleared through both mucociliary escalator mechanism and alveolar clearance by macrophages. Additionally, a portion of the nanoparticles translocates directly into the circulation.
Article
Medicine, Research & Experimental
Jin-Ah Beak, Min-Jung Park, Se-Young Kim, JooYeon Jhun, Jin Seok Woo, Jeong Won Choi, Hyun Sik Na, Soon Kyu Lee, Jong Young Choi, Mi-La Cho
Summary: The combination of Lactobacillus acidophilus and FK506 has been found to effectively control graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation. It inhibits the differentiation of pro-inflammatory T cells and promotes the differentiation of regulatory T cells, as well as modulating the immune function and alleviating GvHD symptoms. This combination treatment also shows potential in regulating immune responses in healthy individuals and liver transplant patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Soon Kyu Lee, Min-Jung Park, Jeong Won Choi, Jin-Ah Baek, Se-Young Kim, Ho Joong Choi, Young Kyoung You, Jeong Won Jang, Pil Soo Sung, Si Hyun Bae, Seung Kew Yoon, Jong Young Choi, Mi-La Cho
Summary: In this study, a patient-derived avatar model was developed to predict immune homeostasis in liver transplantation patients. The model showed promise in evaluating treatment responses and reducing risks to patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Daniel J. Fesenmeier, Sungwan Park, Seyoung Kim, You-Yeon Won
Summary: This study investigates the hypothesis that the surface mechanical properties of poly(styrene)-poly(ethylene glycol) (PS-PEG) micelles are influenced by the structure of the PEG corona. Changes in micelle aggregation number and the chemistry of the PS-PEG block copolymer are expected to alter the characteristics of the PEG corona and affect the surface mechanical properties of the resulting micelle film.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Wooseok Choi, Wonjae Ji, Seongjae Heo, Donguk Lee, Kyungmi Noh, Chuljun Lee, Jiyong Woo, Seyoung Kim, Hyunsang Hwang
Summary: In this study, the read noise of RRAM is utilized for implementing probabilistic neural network, and the electrical characteristics of TiOx-based RRAM under different forming conditions are analyzed. An array mapping scheme is demonstrated to transfer weights to the 1T1R array, and through NN simulations, the promising results of the probabilistic NN over deterministic NN on nonlinear classification problem are validated.
IEEE ELECTRON DEVICE LETTERS
(2022)
Article
Biotechnology & Applied Microbiology
Sung-Goo Kang, Tae-Geun Gweon, Han Hee Lee, Kang-Moon Lee, Sung Hoon Jung, Sang-Bum Kang
Summary: This study validated the reliability and construct validity of the Korean version of CUCQ-8 in patients with IBD, indicating that it can be used to evaluate the quality of life of patients.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Physical
SeYoung Kim, Hyungyeon Cha, Robert Kostecki, Guoying Chen
Summary: All-solid-state batteries, composed of a 4 V class layered oxide cathode, an inorganic solid-state electrolyte, and a lithium metal anode, are seen as the future of energy storage technologies. However, there are challenges related to dendrite formation and cathode instabilities that hinder their development. In this study, composite cathode structures were developed to address these challenges, resulting in exceptional performance and stability in ASSB cells. The study emphasizes the importance of proper cathode composite design for better-performing ASSB cells.
ACS ENERGY LETTERS
(2023)
Article
Gastroenterology & Hepatology
Han Hee Lee, Kyu-na Lee, Jin Su Kim, Dae Young Cheung, Hyuk-Sang Kwon, Bo-In Lee, Young-Seok Cho, Soo-Heon Park, Kyungdo Han, Jin Il Kim
Summary: This study investigated the association between changes in physical activity status and the development of colorectal cancer in patients with diabetes. The results showed that patients with diabetes who remained physically active had the lowest risk of developing colorectal cancer, while those who changed from inactive to active also had a reduced risk.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Ji Hee Song, Seong Ran Jeon, Jin Su Kim, Bo-In Lee, Jin-Oh Kim, Han Hee Lee
Summary: A retrospective study showed that non-ERCP balloon-assisted enteroscopy (BAE) is an effective and safe method for patients with surgically altered gastrointestinal (GI) tract anatomy, with high technical success rate and diagnostic and therapeutic yields.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, General & Internal
Han Hee Lee, Tae-Geun Gweon, Sung-Goo Kang, Sung Hoon Jung, Kang-Moon Lee, Sang-Bum Kang
Summary: This study investigated the degree of fatigue and associated factors in patients with inflammatory bowel disease (IBD). The results showed that patients with IBD experienced moderate to severe fatigue, and factors such as disease activity, use of biologics, history of surgery for IBD, and depression were associated with fatigue.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Han Hee Lee, Jae Jun Park, Bo-In Lee, Ida Hilmi, Jose Sollano, Zhi Hua Ran
Summary: This study aimed to identify disparities in the process of the diagnosis of inflammatory bowel disease (IBD) in Asian countries/regions. A multinational web-based survey was conducted and found differences in diagnostic methods, activity assessment, and the use of markers among various countries/regions. These results can provide insights for the development of Asian guidelines.
INTESTINAL RESEARCH
(2023)
Article
Andrology
Jihye Choi, Seyoung Kim, Seung-Ju Lee, Sangrak Bae, Sooyoun Kim
Summary: This study found that Korean mothers have limited knowledge about male HPV vaccination, have low perceived risk of HPV, and remain highly hesitant about vaccinating their sons. Therefore, it is important to raise public awareness about male HPV vaccination and alleviate vaccine hesitancy.
WORLD JOURNAL OF MENS HEALTH
(2023)