Antibody repertoire analysis in polygenic autoimmune diseases

Direct measurement of B-cell receptor repertoire’s composition and variation in systemic lupus erythematosus

(2017) S Liu et al.   GENES AND IMMUNITY

Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

(2017) Jean-Nicolas Schickel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rituximab induces clonal expansion of IgG memory B-cells in patients with inflammatory central nervous system demyelination

(2016) Michael A. Maurer et al.   JOURNAL OF NEUROIMMUNOLOGY

IMPre: An Accurate and Efficient Software for Prediction of T- and B-Cell Receptor Germline Genes and Alleles from Rearranged Repertoire Data

(2016) Wei Zhang et al.   Frontiers in Immunology

Short-term assessment of BCR repertoires of SLE patients after high dose glucocorticoid therapy with high-throughput sequencing

(2016) Bin Shi et al.   SpringerPlus

Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

(2015) T. S. Dodev et al.   ALLERGY

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

(2015) Christopher M Tipton et al.   NATURE IMMUNOLOGY

Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences

(2015) Jacob D. Galson et al.   EBioMedicine

Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation

(2014) Eduardo Beltrán et al.   BRAIN

Heavy–light chain interrelations of MS-associated immunoglobulins probed by deep sequencing and rational variation

(2014) Yakov A. Lomakin et al.   MOLECULAR IMMUNOLOGY

Autoreactive IgE Is Prevalent in Systemic Lupus Erythematosus and Is Associated with Increased Disease Activity and Nephritis

(2014) Barbara Dema et al.   PLoS One

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

IgG, IgM, and IgA Antinuclear Antibodies in Discoid and Systemic Lupus Erythematosus Patients

(2014) Sheridan A. Jost et al.   TheScientificWorldJOURNAL

Barcode-Enabled Sequencing of Plasmablast Antibody Repertoires in Rheumatoid Arthritis

(2014) Yann-Chong Tan et al.   Arthritis & Rheumatology

Accumulation of VH Replacement Products in IgH Genes Derived from Autoimmune Diseases and Anti-Viral Responses in Human

(2014) Miles D. Lange et al.   Frontiers in Immunology

Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis

(2013) Priscilla F Kerkman et al.   ANNALS OF THE RHEUMATIC DISEASES

Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity

(2013) M E Doorenspleet et al.   ANNALS OF THE RHEUMATIC DISEASES

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-dsDNA Antibody Isotypes in Systemic Lupus Erythematosus: IgA in Addition to IgG Anti-dsDNA Help to Identify Glomerulonephritis and Active Disease

(2013) Danilo Villalta et al.   PLoS One

IgM Repertoire Biodiversity is Reduced in HIV-1 Infection and Systemic Lupus Erythematosus

(2013) Li Yin et al.   Frontiers in Immunology

The immunoglobulin heavy chain locus: genetic variation, missing data and implications for human disease

(2012) C T Watson et al.   GENES AND IMMUNITY

Variable Region Identical Immunoglobulins Differing in Isotype Express Different Paratopes

(2012) Alena Janda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of adjuvants on IgG subclasses elicited by virus-like Particles

(2012) Maria Luisa Visciano et al.   Journal of Translational Medicine

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis

(2011) Henner Morbach et al.   ARTHRITIS AND RHEUMATISM

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2011) Alessandro Michelutti et al.   MOLECULAR MEDICINE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Identification of Novel Susceptibility Loci for Kawasaki Disease in a Han Chinese Population by a Genome-Wide Association Study

(2011) Fuu-Jen Tsai et al.   PLoS One

Alternative mechanisms of receptor editing in autoreactive B cells

(2011) O. Kalinina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Plasmablast Biomarker for Nonresponse to Antibody Therapy to CD20 in Rheumatoid Arthritis

(2011) K. Owczarczyk et al.   Science Translational Medicine

High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations

(2010) Y.-C. Wu et al.   BLOOD

Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab

(2010) H. E. Mei et al.   BLOOD

Allelic exclusion of immunoglobulin genes: models and mechanisms

(2010) Christian Vettermann et al.   IMMUNOLOGICAL REVIEWS

B cells as therapeutic targets in SLE

(2010) Iñaki Sanz et al.   Nature Reviews Rheumatology

Clonal expansion of B-cells in human systemic lupus erythematosus: Evidence from studies before and after therapeutic B-cell depletion

(2009) Petros P. Sfikakis et al.   CLINICAL IMMUNOLOGY

Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases

(2009) Glinda S. Cooper et al.   JOURNAL OF AUTOIMMUNITY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals

(2009) Emmanuel Derudder et al.   NATURE IMMUNOLOGY

Class-switched B cells display response to therapeutic B cell depletion in rheumatoid arthritis

(2009) Burkhard Moller et al.   ARTHRITIS RESEARCH & THERAPY

Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor

(2009) M Margarida Souto-Carneiro et al.   ARTHRITIS RESEARCH & THERAPY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET