Article
Oncology
Shalu Sharma Kharkwal, Christopher T. Johndrow, Natacha Veerapen, Himanshu Kharkwal, Noemi A. Saavedra-Avila, Leandro J. Carreno, Samantha Rothberg, Jinghang Zhang, Scott J. Garforth, Peter J. Jervis, Lianjun Zhang, Alena Donda, Amareeta K. Besra, Liam R. Cox, Steven C. Almo, Alan Howell, Elizabeth E. Evans, Maurice Zauderer, Gurdyal S. Besra, Steven A. Porcelli
Summary: A novel bispecific T-cell engager (BiTE) was developed to activate iNKT cells for antitumor immunity, enhancing multiple effector functions and promoting tumor-specific CD8(+) cytolytic T-cell responses. Simultaneous checkpoint blockade with anti-CTLA-4 antibodies further enhanced the antitumor effects, providing a potential approach for combination immunotherapy. Multiple injections of covalently stabilized iNKT cell-specific BiTEs led to effective and nontoxic cancer immunotherapy regimens without inducing anergy or exhaustion in responding iNKT cells.
Article
Immunology
Thibault Ghesquiere, Marion Ciudad, Andre Ramon, Helene Greigert, Claire Gerard, Claudie Cladiere, Marine Thebault, Coraline Genet, Herve Devilliers, Francois Maurier, Paul Ornetti, Valerie Quipourt, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Georges Tarris, Laurent Martin, Agnes Soudry-Faure, Philippe Saas, Sylvain Audia, Bernard Bonnotte, Maxime Samson
Summary: This study found that MAIT cells in patients with giant cell arteritis (GCA) have differences in cytokine production and proliferation, suggesting that MAIT may play a role in the pathogenesis of GCA.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Allergy
Robert Ose, Benno Weigmann, Detlef Schuppan, Ari Waisman, Joachim Saloga, Iris Bellinghausen
Summary: CD56(+)CD3(+) iNKT cells promote allergen-specific gut and lung inflammation in PBMC-engrafted humanized mice, opening up new possibilities for therapeutic intervention in allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Xiaoyan Ye, Qing Bao, Hexin Chen, Qingxiang Meng, Qianying Li, Lin Sun, Jian Li, Wenbin Lei, Weiping Wen, Wenjing He, Linyi Jiao, Bixing Fang, Yifang Gao, Chunwei Li
Summary: iNKT cells play a role in the inflammatory subtypes of CRSwNP, with type 2 and type 17 iNKT cells being involved in eosinophilic and neutrophilic inflammation, respectively.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Margaret R. Dunne, Johannes Wagener, Juergen Loeffler, Derek G. Doherty, Thomas R. Rogers
Summary: This review examines evidence on the human immune response to invasive fungal diseases, with a focus on unconventional lymphocytes such as NK cells, gamma/delta T cells, MAIT cells, iNKT cells, and ILC. Recent discoveries about the roles of these novel lymphocyte groups in antifungal immunity are discussed, and the potential for improving antifungal treatment options through a better understanding of lymphocyte actions is explored.
CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Xiang Li, Chen Jin, Qi Chen, Xihua Zheng, Di Xie, Qielan Wu, Lu Wang, Shiyu Bai, Huimin Zhang, Li Bai
Summary: Invariant NK T (iNKT) cells are enriched in the liver, where a liver-specific CD24(+) iNKT subset with high proliferation and metabolism activity is found but lower granzyme B production. The liver microenvironment also influences the differentiation of conventional T cells, leading to the generation of CD24(+) T cells with different functional characteristics. These findings suggest that the liver microenvironment may induce the generation of a liver-specific iNKT subset that plays a crucial role in maintaining liver homeostasis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Ellie-May Jarvis, Shaun Collings, Astrid Authier-Hall, Nathaniel Dasyam, Brendan Luey, John Nacey, Gavin F. Painter, Brett Delahunt, Ian F. Hermans, Robert Weinkove
Summary: Prostate cancer is associated with dysfunction of MAIT cells, which may be overcome through the application of potent MR-1 ligands with PD-1 blockade. These findings have implications for the development of cancer immunotherapies that exploit MAIT cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Takahiro Uchida, Shuhji Seki, Takashi Oda
Summary: Natural killer T (NKT) cells and NK cells have important roles in antitumor and antimicrobial functions. They are involved in various renal diseases, including acute kidney injury (AKI). NKT cells in mice are activated by specific ligands, cytokines, and bacterial components, leading to AKI. Both renal vascular endothelial cell injury (via perforin-mediated pathway) and tubular epithelial cell injury (via tumor necrosis factor-alpha/Fas ligand pathway) are independently involved in the pathogenesis of AKI. NK cells complement the functions of NKT cells in the development of infection-associated AKI. Human CD56(+) T cells, which are functional counterparts of murine NKT cells, and a subpopulation of CD56(+) NK cells damage intrinsic renal cells in vitro upon activation, possibly through mechanisms similar to those in mice. These cells are also thought to be involved in the acute exacerbation of pre-existing glomerulonephritis triggered by infection in humans, and their roles in sepsis-associated AKI are currently under investigation. In this review, we provide an overview of recent advances in the understanding of the association among infections, NKT and NK cells, and kidney injury, which is much more profound than previously considered. The important role of liver macrophages in the activation of NKT cells is also introduced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Tan-Huy Chu, Manh-Cuong Vo, Thangaraj Jaya Lakshmi, Seo-Yeon Ahn, Mihee Kim, Ga-Young Song, Deok-Hwan Yang, Jae-Sook Ahn, Hyeoung-Joon Kim, Sung-Hoon Jung, Je-Jung Lee
Summary: The study suggests that novel multipotent mDCs generated by the addition of IL-15 exhibit outstanding activation of T cells, CIK cells, and NK cells, which may facilitate cellular immunotherapy for cancer patients by inducing strong cytotoxicity against myeloma cells.
TRANSLATIONAL ONCOLOGY
(2022)
Review
Immunology
Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj
Summary: Every type of cancer tissue is more susceptible to viral infection, which has been utilized as a new anti-cancer therapy using oncolytic viruses (OVs). OVs selectively infect and destroy cancer cells while causing no harm to the host. Research focuses on the interaction between OVs and the host immune system, particularly the role of dendritic cells (DCs) and natural killer (NK) cells in the therapeutic response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Hong Zhou, Junting Xu, Ling Hong, Yanping Jia, Lilo Valerie Burk, Fengli Chi, Mei Zhao, Xiaohong Guan, Dan Liu, Xiangjie Yin, Yiqiao Zhang, Xiaoming Teng, Liyan Duan, Kunming Li
Summary: This study aimed to evaluate the correlation between characteristics of PCOS and MAIT cells as well as their impact on cytokine secretion. The results showed that the frequency of MAIT cells was significantly reduced in the blood of PCOS patients and negatively correlated with BMI, HOMA-IR index, and AMH. The cytokine IL-17 was significantly higher in PCOS patients and negatively correlated with the frequency of MAIT cells. The frequency change of MAIT cells may play a significant role in the pathogenesis of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Qibin Lin, Tong Wang, Xiaoshu Zuo, Haiyang Ni, Jieying Zhong, Liying Zhan, Hong Cheng, Yi Huang, Xuhong Ding, Hongying Yu, Hanxiang Nie
Summary: This study found that anti-CD1d treatment can suppress Th2 cell responses by inhibiting the immunogenic maturation of LDCs dependent on lung iNKT cells in asthmatic mice. The downregulation of CD40L expression on lung iNKT cells in asthmatic mice may be partially related to this mechanism.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Yan-Ruide Li, Kuangyi Zhou, Matthew Wilson, Adam Kramer, Yichen Zhu, Niels Dawson, Lili Yang
Summary: Human mucosal-associated invariant T (MAIT) cells express an invariant TCR a chain and a restricted TCR b chain, bridging the innate and acquired immune systems. MAIT cells recognize microbial peptides presented by MR1 and play a role in antitumor immunity. Activation of MAIT cells leads to proliferation, cytokine production, and efficient antitumor immune response. This review highlights the biology of MAIT cells, their importance in antitumor immunity, and potential applications in cancer treatment.
Review
Immunology
Xue Wen, Xingli Zhang, Siji Nian, Gang Wei, Xiyuan Guo, Hong Yu, Xiang Xie, Yingchun Ye, Qing Yuan
Summary: MAIT cells, a subset of unconventional T cells, play an important role in immune surveillance and lung diseases. Despite their small proportion in lung immune cells, evidence suggests they can mediate immune response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Yiqiu Wei, Jinli Ding, Jianan Li, Songchen Cai, Su Liu, Ling Hong, Tailang Yin, Yan Zhang, Lianghui Diao
Summary: This review emphasizes the importance of immunometabolism in tumor immunology research and the groundbreaking changes it has achieved in recent years, while pointing out the lag in research on immunometabolism in the field of maternal-fetal medicine. It discusses the roles of immunometabolism in the endometrial microenvironment and its regulation of maternal-fetal immune tolerance, proposes some new research directions and perspectives.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Gerhard Wingender
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2016)
Article
Immunology
Alysia M. Birkholz, Enrico Girardi, Gerhard Wingender, Archana Khurana, Jing Wang, Meng Zhao, Sonja Zahner, Petr A. Illarionov, Xiangshu Wen, Michelle Li, Weiming Yuan, Steven A. Porcelli, Gurdyal S. Besra, Dirk M. Zajonc, Mitchell Kronenberg
JOURNAL OF IMMUNOLOGY
(2015)
Review
Biochemistry & Molecular Biology
Mustafa Gokhan Ertosun, Fatma Zehra Hapil, Osman Nidai Ozes
CYTOKINE & GROWTH FACTOR REVIEWS
(2016)
Letter
Immunology
Shilpi Chandra, Gerhard Wingender, Jason A. Greenbaum, Mitchell Kronenberg
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Shilpi Chandra, Gerhard Wingender, Jason A. Greenbaum, Archana Khurana, Amin M. Gholami, Anusha-Preethi Ganesan, Michael Rosenbach, Katy Jaffee, James E. Gern, Robert Wood, George O'Connor, Megan Sandel, Meyer Kattan, Leonard Bacharier, Alkis Togias, Anthony A. Horner, Mitchell Kronenberg
JOURNAL OF IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Duygu Sag, Muge Ozkan, Mitchell Kronenberg, Gerhard Wingender
SCIENTIFIC REPORTS
(2017)
Review
Oncology
Duygu Sag, Zeynep Ozge Ayyildiz, Sinem Gunalp, Gerhard Wingender
Article
Biochemistry & Molecular Biology
Fatma Zehra Hapil, Fatma Ece Copuroglu, Mustafa Gokhan Ertosun, Ufuk Mert, Derya Ozes, Osman Nidai Ozes
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2020)
Article
Multidisciplinary Sciences
Muge Ozkan, Yusuf Cem Eskiocak, Gerhard Wingender
Summary: The identification of immune effector functions, particularly those involving IL-10 production, is crucial for understanding immune responses. While IL-10(GFP) reporter lines can accurately report on IL-10 production by lymphoid cells, they may not be suitable for analyzing myeloid cell IL-10 production, as autofluorescence can interfere with GFP signals. This highlights a potential technical limitation when using GFP-reporter lines for studying myeloid cells in inflammation.
Article
Multidisciplinary Sciences
Muge Ozkan, Yusuf Cem Eskiocak, Gerhard Wingender
Summary: Asthma is a heterogeneous disease that can be classified into eosinophilic asthma and neutrophilic asthma. Eosinophilic asthma is treatment-responsive and associated with allergic asthma, while neutrophilic asthma is treatment-resistant. Understanding the differences between these endotypes is crucial for developing effective diagnosis and treatment strategies.
Article
Multidisciplinary Sciences
Yusuf Cem Eskiocak, Zeynep Ozge Ayyildiz, Sinem Gunalp, Asli Korkmaz, Derya Goksu Helvaci, Yavuz Dogan, Duygu Sag, Gerhard Wingender
Summary: Various aspects of in vitro culture conditions, including elevated Ca2+ concentrations, can impact the functional response of immune cells. The presence of elevated Ca2+ concentrations during in vitro stimulation can increase cytokine production in both conventional and unconventional T cells, as well as B cells. However, primary human monocyte-derived macrophages showed increased cell death in the presence of elevated Ca2+ concentrations. Furthermore, elevated Ca2+ levels promoted M1 differentiation in macrophages. This study highlights the importance of considering the Ca2+ concentration in in vitro cultures for functional experiments and the potential of elevated Ca2+ levels to boost cytokine production in lymphoid cells.
Article
Biology
Fatma Ece Copuroglu, Fatma Zehra Hapil, Sukran Burcak Yoldas, Osman Nidai Ozes
Summary: The study revealed that mutations in the SH3 domain of TNFR1 affect the activation of ERK, AKT, JNK, and p38 mediated by TNF alpha, providing further insight into the TNFR1 signaling pathway.
TURKISH JOURNAL OF BIOLOGY
(2021)
Article
Biology
Mustafa Gokhan Ertosun, Sayra Dilmac, Fatma Zehra Hapil, Gamze Tanriover, Sadi Koksoy, Osman Nidai Ozes
TURKISH JOURNAL OF BIOLOGY
(2020)