Article
Computer Science, Information Systems
Ya-Han Liu, Hsin-Yi Su, Hsiao-Chi Lin, Chih-Ying Li, Yeong-Her Wang, Chih-Hsien Huang
Summary: This study proposes a small-sized and low-power piezoelectric micromachined ultrasonic transducer (pMUT) to replace traditional transducers for ultrasound haptics applications. The optimized design procedures and fabrication process of the pMUT platform are successfully demonstrated, showing its potential.
Article
Materials Science, Multidisciplinary
Jenna M. Shapiro, Bruce W. Drinkwater, Adam W. Perriman, Mike Fraser
Summary: Sonolithography is a material handling technique that uses acoustic fields to manipulate particles in fluids. It relies on the interference of ultrasonic standing waves to pattern materials onto substrates for biofabrication and tissue engineering applications. This cost-effective method is capable of rapidly patterning materials over a macroscale surface area for direct and indirect cell patterning.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Chemistry, Multidisciplinary
Boguslaw Szlachetko
Summary: This paper presents a simplified implementation of a QPSK-based underwater communication system using an ultrasound modem. The aim is to develop inexpensive and compact modems that can be used on underwater robots. The experiments conducted with the prototype modems achieved a data rate of 4 kbps at a distance of approximately 18 m.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Physical
Zhengxin Guan, Liqiang Liu, Xiyan Xu, Acan Liu, Han Wu, Jun Li, Ou-Yang Wei
Summary: In this study, an easy-fabricated and compact-structured ultrasound-driven TENG (UD-TENG) is proposed to harvest ultrasonic energy. The coupling mechanism between weak adhesion of the polymer film and ultra-high ultrasonic pressure is investigated. The UD-TENG exhibits high charging rate, stability, and can be applied in underwater ultrasonic wave detection and sound source location.
Article
Chemistry, Analytical
Jian-Chiun Liou, Chih-Wei Peng, Zhen-Xi Chen
Summary: The study explored the use of ultrasonic energy generation and ablation. Ultrasound thermal therapy has potential for treating deep hyperplastic tissues and tumors. High-intensity ultrasound has been gradually applied in clinical treatment.
Article
Chemistry, Analytical
Hayong Jung, K. Kirk Shung, Hae Gyun Lim
Summary: Ultrasound imaging is a valuable tool in imaging human tissues, but conventional transducers face limitations in resolution for cellular applications. By using ultrahigh frequency (UHF) transducers, we achieved high-resolution cell imaging and acoustic tweezers. The results showed successful imaging of single cells and manipulation of cells and beads using the UHF transducers.
Article
Acoustics
Vladimir Nikolaevich Khmelev, Andrey Victorovich Shalunov, Viktor Aleksandrovich Nesterov
Summary: This article presents the development and study of an ultrasonic radiator of increased power for control, location, cavitation processing of liquids, and coagulation of foreign particles in a gaseous media at frequencies from 30 to 90 kHz. Through a method of vibration summing and optimal dimension selection, real designs of US radiators with operating frequencies up to 90 kHz have been successfully created. The US radiator can generate exposure intensity ranging from 34.6 to 45 W/cm2, depending on the power and operating frequency, for cavitation processing of liquids.
Article
Engineering, Biomedical
Chunkyun Seok, Oluwafemi Joel Adelegan, Ali Onder Biliroglu, Feysel Yalcin Yamaner, Omer Oralkan
Summary: An A2D ultrasonic array is the ultimate form of a focused ultrasonic system, enabling beam focusing in a 3D space. Building this system involves complex technologies such as fabricating an array, developing a pitch-matched ASIC, and connecting them. The study presented a novel 32x32 CMUT array system, showcasing the capabilities of a 2D ultrasonic system.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2021)
Article
Chemistry, Analytical
Jinhyuk Kim, Jungwoo Lee
Summary: This study investigates the functionality of Langevin type transducers by applying pulsed waves and compares their thermal effects with continuous waves. The results show that pulsed excitation reduces the thermal influence on the transducer compared to continuous excitation.
Review
Crystallography
Qiongyuan Li, Lifeng Yang, Shengjian Zhang, Fen Wang, Yu Gu, Xiaochun Deng, Yingguo Yang
Summary: This article firstly introduces the research progress of commonly used piezoelectric materials in the field of ultrasound medicine, as well as the potential application of organic and inorganic halide perovskite materials in piezoelectric-effect devices. Then, the design and application of perovskite materials in ultrasonic transducers are discussed. Finally, the future development of organic and inorganic halide perovskite materials in the field of ultrasound medicine is outlooked.
Article
Acoustics
Yizhe Sun, Laiming Jiang, Ruimin Chen, Runze Li, Haochen Kang, Yushun Zeng, Yongke Yan, Shashank Priya, Qifa Zhou
Summary: This study successfully developed a highly textured piezoelectric ceramic material and fabricated a 15 MHz ultrasound transducer based on this material. The experimental results showed that the fabricated transducer performed well in terms of image quality and has the potential for application in biomedical imaging.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Chemistry, Multidisciplinary
Qiongfeng Shi, Zhongda Sun, Xianhao Le, Jin Xie, Chengkuo Lee
Summary: A soft robotic perception system with remote object positioning and multimodal cognitive capability is developed by integrating an ultrasonic sensor with flexible triboelectric sensors. The system allows for accurate object positioning and identification, expanding the adaptability of current soft robotic systems in various applications.
Article
Optics
Afshin Kashani Ilkhechi, Christopher Ceroici, Eric Dew, Roger Zemp
Summary: Transparent ultrasound transducers, such as capacitive micromachined ultrasound transducers (CMUTs), have been developed for combined ultrasound imaging and through-array white-light imaging. These devices provide high transparency and sensitivity, with excellent lateral and axial resolutions. The technology enables real-time optical and ultrasonic imaging with potential applications in interventional and surgical procedures.
Article
Chemistry, Analytical
Ke Zhu, Jinpeng Ma, Xudong Qi, Bingzhong Shen, Yang Liu, Enwei Sun, Rui Zhang
Summary: This work presents the design and fabrication of an anisotropic gradient acoustic impedance composite material as a matching layer for ultrasonic transducers, which achieves almost perfect sound energy transfer efficiency by gradually decreasing the acoustic impedance along the direction of ultrasonic propagation. By using this new material as a matching layer, it has the potential to significantly improve the resolution and imaging quality of biomedical ultrasound imaging systems.
Article
Physics, Applied
Andrew Feeney, Lei Kang, Steve Dixon
Summary: This study investigates the higher order modal dynamics of the flexural ultrasonic transducer (FUT) through experimental measurement and theoretical analysis, expanding the potential industrial applications of FUT.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Chikahiro Imashiro, Yuta Ida, Shogo Miyata, Jun Komotori
Summary: Surgery, radiation therapy, and chemical therapy are the main treatments for cancer, but hyperthermia has been studied as a non-invasive treatment due to its high invasiveness. Hyperthermia uses the difference in thermal tolerance between normal and cancer cells to selectively kill cancer cells through thermal stimulation. To develop effective conditions for hyperthermia, an in vitro study is needed to evaluate the thermal tolerance of cells. However, existing cell culture vessels cannot control the culture temperature properly, making it difficult to investigate the genuine thermal tolerance of cells. Therefore, the development of a culture device that can control culture temperature is crucial.
MATERIALS TRANSACTIONS
(2022)
Article
Automation & Control Systems
Henrik Krauss, Kenjiro Takemura
Summary: This study presents a highly stretchable optical waveguide sensor that extends existing solutions to two degrees of freedom while maintaining low manufacturing complexity and part count. Experimental comparison verifies the effective application of the proposed sensor in four different strain scenarios.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Pharmacology & Pharmacy
Xue Xie, Yuta Kurashina, Makoto Matsui, Takahiro Nomoto, Munenari Itoh, Hirotaka J. Okano, Kentaro Nakamura, Nobuhiro Nishiyama, Yoshitaka Kitamoto
Summary: The study proposed a transdermal delivery system using sonophoresis with carboxymethyl chitosan nanocarriers to administer bFGF over a wide area of skin. Through ex vivo experiments, the effectiveness of the delivery system was demonstrated, showing that the penetration of bFGF-loaded carboxymethyl chitosan nanocarriers with ultrasound was significantly higher than ultrasound irradiation alone. This research paves the way for future use of polymeric nanocarriers using sonophoresis for biomacromolecule administration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Momoko Sagara, Lisako Nobuyama, Kenjiro Takemura
Summary: Tactile sensing has attracted significant attention as a method for evaluating consumer products. This study proposes a nonlinear tactile estimation model that can estimate sensory evaluation scores from physical measurements. The results suggest that nonlinear regression models can provide more accurate results.
Article
Acoustics
Chikahiro Imashiro, Jiyang Mei, James Friend, Kenjiro Takemura
Summary: The strength of cell adhesion is crucial for understanding cell health and culturing cells. This study introduces a system that uses acoustic streaming induced by Lamb waves to measure cell adhesion strength. By exposing cells to shear flows, cells are detached, and the corresponding detachment force is determined to be in the range of several nN. The system offers a wide range of quantifying cell adhesion strength, making it a fundamental tool for cell-based bioengineering.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Motoki Hirabayashi, Sho Kurihara, Ryuya Ito, Yuta Kurashina, Masaomi Motegi, Hirotaka James Okano, Yutaka Yamamoto, Hiromi Kojima, Takumi Asakura
Summary: Acoustic analysis using finite element models can simulate audiograms for different ossicular chain defects and provide insights into the pathogenesis of conductive hearing loss.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chikahiro Imashiro, Takashi Morikura, Motoaki Hayama, Atsushi Ezura, Jun Komotori, Shogo Miyata, Katsuhisa Sakaguchi, Tatsuya Shimizu
Summary: This article introduces the method of using 3D printing of metal to manufacture culture devices and its potential and application in bioengineering research. By creating mesh structures on the culture surfaces, the culture environment of tissues can be improved, leading to enhanced nutrient supply. The technology of manufacturing culture devices using metal 3D printing demonstrates good biocompatibility and reusability.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Shuhei Takatsuka, Takeshi Kubota, Yuta Kurashina, Hiroaki Onoe
Summary: This study proposes a gene therapy method using alginate hydrogel microbeads and a heat transducer for near-infrared (NIR)-triggered on-demand release of adeno-associated virus (AAV). The Fe3O4 microparticles (Fe3O4-MPs) in the microbeads generate heat by NIR, increasing the diffusion speed of AAV and releasing it. The system is confirmed to release virus with a diameter of several tens of nanometers. This research expands the options for drug release methods in gene therapy.
Editorial Material
Biotechnology & Applied Microbiology
Filippo Rossi, Yuta Kurashina, Hiroaki Onoe
Article
Acoustics
Yasuhiko Orita, Susumu Shimanuki, Satoshi Okada, Kentaro Nakamura, Hiroyuki Nakamura, Yoshitaka Kitamoto, Yusuke Shimoyama, Yuta Kurashina
Summary: This study demonstrated the superior acoustic responsiveness of liposomes synthesized under high pressure from supercritical CO2 and irradiated with ultrasound at 237 kHz. The release efficiency of CO2-loaded liposomes was 17.1 times higher than liposomes synthesized using the conventional Bangham method. Liposomes synthesized using supercritical CO2 and mono-ethanolamine had a release efficiency that was 19.8 times higher than the conventional Bangham method. These findings suggest a new liposome synthesis strategy for on-demand drug release using ultrasound irradiation in future therapies.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Clinical Neurology
Teppei Komatsu, Hiroki Ohta, Naoki Takakura, Junichi Hata, Tomomichi Kitagawa, Yuta Kurashina, Hiroaki Onoe, Hirotaka James Okano, Yasuyuki Iguchi
Summary: This study developed a stem cell-implantable radiopaque hydrogel microfiber that can survive in vivo for a long time, aiming to establish a novel stroke model and determine the efficacy of cell transplantation in treating stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hiroaki Takeya, Shun Itai, Hiroo Kimura, Yuta Kurashina, Tsuyoshi Amemiya, Narihito Nagoshi, Takuji Iwamoto, Kazuki Sato, Shinsuke Shibata, Morio Matsumoto, Hiroaki Onoe, Masaya Nakamura
Summary: This study investigated the nerve regeneration effect of a Schwann cell-encapsulated chitosan-collagen hydrogel nerve conduit (CCN) in a rat model of sciatic nerve defect. The results showed that the CCN group with Schwann cell encapsulation had better motor functional recovery, axonal regrowth, and myelination compared to the CCN group without Schwann cells and the silicone tube group. Therefore, the Schwann cell-encapsulated CCN is a promising approach for peripheral nerve regeneration.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Keitaro Kasahara, Jumpei Muramatsu, Yuta Kurashina, Shigenori Miura, Shogo Miyata, Hiroaki Onoe
Summary: This study utilizes a novel stretch and optical imaging system to conduct spatiotemporal single-cell tracking analysis of cellular behavior in vitro 3D tissues under mechanical stretch. It reveals the heterogeneous and spatiotemporally dynamic cellular response in tissue.
Article
Computer Science, Information Systems
Koki Hatori, Kenjiro Takemura
Summary: Tactile rendering is a promising technology that needs to be integrated into various virtual reality environments. This study developed a model that generates appropriate input signals for an ultrasonic tactile display using a conditional generative adversarial network. The models were trained using sensory evaluation scores and vibration data. Different cluster analysis conditions were used to create the input information, and the accuracy of the models was evaluated through sensory evaluation experiments. The results showed improved accuracy and reproducibility of tactile sensation using the developed models.
Proceedings Paper
Engineering, Electrical & Electronic
Akari Masuda, Keisuke Fukada, Shun Itai, Yuta Kurashina, Shuichi Akizuki, Shugo Tohyama, Jun Fujita, Hiroaki Onoe
Summary: The study introduced a novel cardiac tissue drug screening model using core-shell microfiber-shaped design and a fixation-free contractile force measurement system, which can evaluate the response of cardiac tissue to different drugs, providing a new approach for research on unexplained cardiac diseases and pharmacokinetic testing.
2022 IEEE 35TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE (MEMS)
(2022)