Review
Peripheral Vascular Disease
Carlos Escudero, Ellen Kupka, Belen Ibanez, Hermes Sandoval, Felipe Troncoso, Anna-Karin Wikstroem, Daniela Lopez-Espindola, Jesenia Acurio, Pablo Torres-Vergara, Lina Bergman
Summary: Preeclampsia is a maternal syndrome characterized by hypertension and proteinuria after 20 weeks of gestation with brain complications being the main cause of morbidity and mortality, especially in low- and middle-income countries. In addition to the cardiovascular effects, women with preeclampsia have higher risk of stroke, dementia, white matter lesions, epilepsy, and cognitive decline postpartum, and evidence also links preeclampsia with similar cognitive and cerebral disorders in offspring. However, the mechanistic links between these associations remain unresolved. This article summarizes the current knowledge and potential pathophysiological mechanisms of cerebrovascular complications in preeclampsia.
Article
Peripheral Vascular Disease
Anna Kivioja, Elli Toivonen, Jaakko Tyrmi, Sanni Ruotsalainen, Samuli Ripatti, Heini Huhtala, Tiina Jaaskelainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Tanja Saarela, Hannele Laivuori
Summary: The study found that the polygenic risk score for blood pressure (BP-PRS) is associated with an increased risk of preeclampsia and its severe subtypes, with women with high BP-PRS presenting higher blood pressure values during pregnancy.
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Bing He, Yu Liu, Mano R. Maurya, Paula Benny, Cameron Lassiter, Hui Li, Shankar Subramaniam, Lana X. Garmire
Summary: The study identified altered lipid profiles in severe preeclampsia patients, with increased intercorrelations and connections of oxidized phospholipids and reduced network correlations of other lipids. Certain lipid species showed significant changes uniquely associated with preeclampsia, serving as potential biomarkers for the condition. The dysregulated biological pathways enriched with these lipids, such as insulin signaling and immune response, indicate a potential role of the lipidome in the pathogenesis of severe preeclampsia.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Peripheral Vascular Disease
Kyle R. Roell, Quaker E. Harmon, Kari Klungsoyr, Anna E. Bauer, Per Magnus, Stephanie M. Engel
Summary: This study investigated changes in gestational blood pressure trajectories among preeclampsia cases, finding that individuals with a more rapid increase in blood pressure and those with a high starting blood pressure experienced worse pregnancy outcomes.
Article
Medicine, General & Internal
Hsiao-Wen Lu, Han-Shui Hsu
Summary: This study aims to use a combination of maternal-obstetrical characteristics and complete blood cell counts with different red blood cell indices to detect the severity of preeclampsia before delivery. The results show that the combined variables have satisfactory performance in distinguishing severe preeclampsia from other non-hypertensive and hypertensive groups.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Young Mi Jung, Gyu Chul Oh, Eunjin Noh, Hae-Young Lee, Min-Jeong Oh, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee, Geum Joon Cho
Summary: Hypertension before pregnancy, specifically stage I hypertension, increases the risk of obstetric complications. Lower pre-pregnancy blood pressure is associated with better maternal and neonatal outcomes. Pregnant women with stage I hypertension prior to pregnancy should be carefully monitored for adverse outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Cell Biology
Lina Bergman, Roxanne Hastie, Henrik Zetterberg, Kaj Blennow, Sonja Schell, Eduard Langenegger, Ashley Moodley, Susan Walker, Stephen Tong, Catherine Cluver
Summary: The study found evidence of neuroinflammation and an injured blood-brain barrier in women with preeclampsia and eclampsia, especially in those with eclampsia.
Article
Peripheral Vascular Disease
Sonia Johnson, Sanne Gordijn, Stefanie Damhuis, Wessel Ganzevoort, Mark Brown, Peter von Dadelszen, Laura A. Magee, Asma Khalil
Summary: This study used the Delphi procedure to reach consensus on diagnostic criteria and monitoring strategies for white coat hypertension in pregnancy.
Article
Environmental Sciences
Emma Preston, Marie-France Hivert, Abby F. Fleisch, Antonia M. Calafat, Sharon K. Sagiv, Wei Perng, Sheryl L. Rifas-Shiman, Jorge E. Chavarro, Emily Oken, Ami R. Zota, Tamarra James-Todd
Summary: This study found that exposure to certain PFAS may increase the risk of gestational hypertension during pregnancy, with potential implications for maternal and child health outcomes.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Qiuying Zhao, Weiye Dai, Hui Yu Chen, Russell E. Jacobs, Berislav V. Zlokovic, Brett T. Lund, Axel Montagne, Alexandre Bonnin
Summary: Gestational maternal immune activation in mice leads to persistent brain inflammation and neuropathological changes in adult offspring. This study reveals that the disruption of blood-brain barrier (BBB) function is involved in this process, which is caused by increased microglial activation and abnormal prenatal BBB formation driven by COX2 expression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychiatry
Margaret H. Bublitz, Elena Salmoirago-Blotcher, Laura Sanapo, Nina Ayala, Niharika Mehta, Ghada Bourjeily
Summary: This pilot randomized clinical trial suggests that prenatal mindfulness training is feasible and acceptable, and may be a useful adjunctive preventative treatment for hypertensive disorders of pregnancy among at-risk pregnant patients.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Review
Medicine, General & Internal
Elzbieta Poniedzialek-Czajkowska, Radzislaw Mierzynski, Dominik Dluski, Bozena Leszczynska-Gorzelak
Summary: Hypertensive disorders of pregnancy, such as preeclampsia, pose significant risks to both mother and fetus. Aspirin is currently the only recommended pharmacological agent for prevention in high-risk groups, while metformin shows potential as an interesting option for prophylaxis, although further research is needed to clarify its effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Janet M. Catov, Rebecca B. McNeil, Derek J. Marsh, Brian M. Mercer, C. Noel Bairey Merz, Corette B. Parker, Victoria L. Pemberton, George R. Saade, Yii-Der (Ida) Chen, Judith H. Chung, Deborah B. Ehrenthal, William A. Grobman, David M. Haas, Samuel Parry, LuAnn Polito, Uma M. Reddy, Robert M. Silver, Hyagriv N. Simhan, Ronald J. Wapner, Michelle Kominiarek, Rolf Kreutz, Lisa D. Levine, Philip Greenland
Summary: In primiparous women, APO/GDM is associated with atherosclerotic characteristics and increased risk of hypertension later. Higher glucose, high-sensitivity C-reactive protein, and triglycerides levels are linked to hypertension, while increased physical activity is protective. Nonobese individuals with higher lipid, high-sensitivity C-reactive protein, and insulin levels have increased risk of APO/GDM and hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Therese Friis, Anna-Karin Wikstrom, Jesenia Acurio, Jose Leon, Henrik Zetterberg, Kaj Blennow, Maria Nelander, Helena Akerud, Helena Kaihola, Catherine Cluver, Felipe Troncoso, Pablo Torres-Vergara, Carlos Escudero, Lina Bergman
Summary: Cerebral complications in preeclampsia are a significant threat to maternal health and survival. Currently, there is a lack of reliable and accessible predictors for preeclampsia-related cerebral complications. This study found that plasma concentrations of the cerebral biomarkers NfL, tau, NSE, and S100B were all higher in women with preeclampsia compared to women with normal pregnancies and non-pregnant women. In addition, higher plasma concentrations of NfL were associated with decreased blood-brain barrier integrity in an in vitro model.
Review
Clinical Neurology
Samir Abu-Rumeileh, Ahmed Abdelhak, Matteo Foschi, Lucio D'Anna, Michele Russo, Petra Steinacker, Jens Kuhle, Hayrettin Tumani, Kaj Blennow, Markus Otto
Summary: Abu-Rumeileh et al. provide an overview of the role of neurofilament light chain protein as a biomarker in various medical fields. Its validation and application have greatly impacted the diagnosis and prognosis of neurological diseases. Recent studies have also explored its potential applications in non-primary neurological conditions.
Review
Emergency Medicine
Jonas A. Strohm, Peter C. Strohm, Jan Kuehle, Hagen Schmal, Jorn Zwingmann
Summary: This study aimed to investigate the various management approaches for juvenile and aneurysmal bone cysts and evaluate their clinical outcomes. Surgical removal and Doxycycline injection showed excellent healing rates and low recurrence rates for aneurysmal bone cysts. Surgical interventions, especially with autologous cancellous bone graft, were superior to non-surgical approaches in managing juvenile bone cysts.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Clinical Neurology
Marta Kubacka, Annaelle Zietz, Sabine Schaedelin, Alexandros A. Polymeris, Lisa Hert, Johanna Lieb, Benjamin Wagner, David Seiffge, Christopher Traenka, Valerian L. Altersberger, Tolga Dittrich, Joachim Fladt, Urs Fisch, Sebastian Thilemann, Gian Marco De Marchis, Henrik Gensicke, Leo H. Bonati, Philippe Lyrer, Stefan T. Engelter, Nils Peters
Summary: Global cortical atrophy (GCA) is associated with the clinical prognosis of stroke patients with atrial fibrillation (AF) receiving oral anticoagulation.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Tim Spelman, Serkan Ozakbas, Raed Alroughani, Murat Terzi, Suzanne Hodgkinson, Guy Laureys, Tomas Kalincik, Anneke Van der Walt, Bassem Yamout, Jeannette Lechner-Scott, Aysun Soysal, Jens Kuhle, Jose Luis Sanchez-Menoyo, Yolanda Blanco Morgado, Daniele La Spitaleri, Vincent van Pesch, Dana Horakova, Radek Ampapa, Francesco Patti, Richard Macdonell, Abdullah Al-Asmi, Oliver Gerlach, Jiwon Oh, Ayse Altintas, Namita Tundia, Schiffon L. Wong, Helmut Butzkueven
Summary: This study compared treatment patterns and clinical outcomes of multiple sclerosis (MS) patients treated with cladribine tablets versus other oral disease-modifying treatment (DMT) using real-world data. The results demonstrated that cladribine tablets were associated with longer treatment persistence, delayed time to first relapse, and lower relapse rate compared to other oral DMTs.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Pediatrics
Cornelis Smit, Aline G. J. Engbers, Samira Samiee-Zafarghandy, Tamara van Donge, Sinno H. P. Simons, Robert B. B. Flint, Marc Pfister, Catherijne A. J. Knibbe, John N. N. van den Anker
Summary: This study explores the mechanism behind the greater effectiveness of oral ibuprofen compared to intravenous ibuprofen in closing a patent ductus arteriosus. The results show that after oral dosing, the concentration of the biologically active S-enantiomer is lower for a significant portion of the dosing interval. The study also indicates that R- to S-conversion does not exceed 45%.
Article
Surgery
Leonard Simon Brandenburg, Pit Jacob Voss, Thomas Mischkowsky, Jan Kuehle, Michael Andreas Ermer, Julia Vera Weingart, Rene Marcel Rothweiler, Marc Christian Metzger, Rainer Schmelzeisen, Philipp Poxleitner
Summary: This study investigated comorbidity of the hip following deep circumflex iliac artery (DCIA) graft raising using CAD/CAM techniques. The results showed a significant correlation between graft volume and skin incision length with postoperative donor site morbidity. The study suggests that a minimally invasive approach could help reduce postoperative symptomatology in CAD/CAM surgery.
Article
Clinical Neurology
Stephanie Meier, Eline A. J. Willemse, Sabine Schaedelin, Johanna Oechtering, Johannes Lorscheider, Lester Melie-Garcia, Alessandro Cagol, Muhamed Barakovic, Riccardo Galbusera, Suvitha Subramaniam, Christian Barro, Ahmed Abdelhak, Simon Thebault, Lutz Achtnichts, Patrice Lalive, Stefanie Muller, Caroline Pot, Anke Salmen, Giulio Disanto, Chiara Zecca, Marcus D'Souza, Annette Orleth, Michael Khalil, Arabella Buchmann, Renaud Du Pasquier, Ozgur Yaldizli, Tobias Derfuss, Klaus Berger, Marco Hermesdorf, Heinz Wiendl, Fredrik Piehl, Marco Battaglini, Urs Fischer, Ludwig Kappos, Claudio Gobbi, Cristina Granziera, Claire Bridel, David Leppert, Aleksandra Maleska Maceski, Pascal Benkert, Jens Kuhle
Summary: This study found that serum glial fibrillary acidic protein (sGFAP) and serum neurofilament light chain (sNfL) are correlated with features of disease progression in multiple sclerosis (MS) and can predict disease progression. sGFAP may serve as a useful biomarker for disease progression in MS in individual patient management and drug development.
Article
Clinical Neurology
Charidimos Tsagkas, Antal Huck-Horvath, Alessandro Cagol, Tanja Haas, Michael Amann, Muhamed Barakovic, Esther Ruberte, Lester Melie-Garcia, Matthias Weigel, Simon Pezold, Regina Schlaeger, Jens Kuhle, Till Sprenger, Ludwig Kappos, Oliver Bieri, Philippe Cattin, Cristina Granziera, Katrin Parmar
Summary: This study investigated longitudinal changes of cervical spinal cord (cSC) gray and white matter areas in multiple sclerosis (MS) patients. The results showed that patients with clinical progression had a faster reduction of cSC areas over time compared to stable patients. Additionally, compared to patients without clinical progression and healthy controls, only patients with clinical progression demonstrated a preferential reduction of cSC and white matter areas at the level of cSC enlargement.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Neurosciences
A. L. Wenger, Muhamed Barakovic, Sara Bosticardo, Sabine Schaedelin, Alessandro Daducci, Simona Schiavi, Matthias Weigel, Reza Rahmanzadeh, Po-Jui Lu, Alessandro Cagol, Ludwig Kappos, Jens Kuhle, Pasquale Calabrese, Cristina Granziera
Summary: The presence of focal cortical and white matter damage in patients with multiple sclerosis (pwMS) might lead to specific alterations in brain networks that are associated with cognitive impairment. We applied microstructure-weighted connectomes to investigate the relationship between global network metrics and information processing speed in pwMS, and whether the disruption provoked by focal lesions on global network metrics is associated to patients' information processing speed.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Verena Gotta, Sara Bachmann, Marc Pfister, Birgit Donner
Summary: An association was observed between nocturnal hypoglycemia and QT prolongation in children with type 1 diabetes. This pharmacometric analysis aimed to understand this association and determine other sources of QT variability quantitatively.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Clinical Neurology
Giulio Disanto, Michele Villa, Aleksandra Maleska Maceski, Chiara Prosperetti, Claudio Gobbi, Jens Kuhle, Tiziano Cassina, Pamela Agazzi
Summary: Serum neurofilament light (sNfL) is a promising marker for predicting the outcome of cardiac arrest. The study found that sNfL levels were similar between survivors and non-survivors upon admission, but significant differences were observed after 24 hours. sNfL concentrations showed high predictive value for death, especially when early samples were unavailable or prognosis remained uncertain.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Ilaria Callegari, Mika Schneider, Vera Aebischer, Margarete M. M. Voortman, Undine Proschmann, Tjalf Ziemssen, Raija Lindberg, Bettina Fischer-Barnicol, Michael Khalil, Ludwig Kappos, Jens Kuhle, Nicholas S. R. Sanderson, Tobias Derfuss
Summary: This study found that natalizumab can diffuse in different anatomical compartments, including cerebrospinal fluid and milk. By developing a flow-cytometry-based assay and applying it to quantify natalizumab in body fluids, including cerebrospinal fluid, breastmilk, and serum, a better understanding of the safety of therapeutic antibody administration during pregnancy and lactation can be achieved.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Neuroimaging
Xinjie Chen, Sabine Schadelin, Po-Jui Lu, Mario Ocampo-Pineda, Matthias Weigel, Muhamed Barakovic, Esther Ruberte, Alessandro Cagol, Benedicte Marechal, Tobias Kober, Jens Kuhle, Ludwig Kappos, Lester Melie-Garcia, Cristina Granziera
Summary: We developed a method to create personalized qT1 abnormality maps in MS patients and assessed their relationship with disability, demonstrating their potential value in clinical practice.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Nuria Cerda-Fuertes, Sara Nagy, Sabine Schaedelin, Tim Sinnecker, Esther Ruberte, Athina Papadopoulou, Jens Wurfel, Jens Kuhle, Ozgur Yaldizli, Ludwig Kappos, Tobias Derfuss, Bernhard F. Decard
Summary: This study aimed to describe the frequency, severity, and potential risk factors for recurring disease activity (RDA) in patients with multiple sclerosis (pwMS) after discontinuation of fingolimod (FGL). The results showed that younger age, shorter disease duration, and MRI activity during FGL treatment were independent risk factors for post-FGL RDA. Individual risk assessment and early switch to highly effective therapy can help minimize the risk of post-FGL RDA.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Clinical Neurology
Lutz Achtnichts, Chiara Zecca, Oliver Findling, Christian P. Kamm, Stefanie Mueller, Jens Kuhle, Andreas Lutterotti, Claudio Gobbi, Camille Viviani, Emanuela Villiger-Borter, Krassen Nedeltchev
Summary: In patients with multiple sclerosis (MS), relapses and disability progression are associated with decreased health-related quality of life (HRQoL). A study found that treatment with natalizumab for 1 year resulted in improved or stable EDSS status in most patients, and certain domains of HRQoL seemed to improve.
BMJ NEUROLOGY OPEN
(2023)