Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia

Targeting potassium channels to treat cerebellar ataxia

(2018) David D. Bushart et al.   Annals of Clinical and Translational Neurology

Potassium channel dysfunction underlies Purkinje neuron spiking abnormalities in spinocerebellar ataxia type 2

(2017) James M Dell’Orco et al.   HUMAN MOLECULAR GENETICS

Long-Term Depression of Intrinsic Excitability Accompanied by Synaptic Depression in Cerebellar Purkinje Cells

(2017) Hyun Geun Shim et al.   JOURNAL OF NEUROSCIENCE

Polyglutamine spinocerebellar ataxias — from genes to potential treatments

(2017) Henry L. Paulson et al.   NATURE REVIEWS NEUROSCIENCE

In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model

(2016) Polina A. Egorova et al.   JOURNAL OF NEUROPHYSIOLOGY

Prolonged Type 1 Metabotropic Glutamate Receptor Dependent Synaptic Signaling Contributes to Spino-Cerebellar Ataxia Type 1

(2016) Emmet M. Power et al.   JOURNAL OF NEUROSCIENCE

Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice

(2016) Anton N. Shuvaev et al.   JOURNAL OF PHYSIOLOGY-LONDON

4-aminopyridine reverses ataxia and cerebellar firing deficiency in a mouse model of spinocerebellar ataxia type 6

(2016) Sriram Jayabal et al.   Scientific Reports

Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability

(2015) J. M. Dell'Orco et al.   JOURNAL OF NEUROSCIENCE

Protein kinase C bidirectionally modulatesIhand hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression in hippocampal pyramidal neurons

(2015) Aaron D. Williams et al.   JOURNAL OF PHYSIOLOGY-LONDON

Kv3.3 potassium channels and spinocerebellar ataxia

(2015) Yalan Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

“Slow” Voltage-Dependent Inactivation of CaV2.2 Calcium Channels Is Modulated by the PKC Activator Phorbol 12-Myristate 13-Acetate (PMA)

(2015) Lei Zhu et al.   PLoS One

Tuning the signalling output of protein kinase C

(2014) Corina E. Antal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14

(2014) Jingmin Ji et al.   NEUROBIOLOGY OF DISEASE

Insights From Cerebellar Transcriptomic Analysis Into the Pathogenesis of Ataxia

(2014) Conceição Bettencourt et al.   JAMA Neurology

Clinical Neurogenetics

(2013) Vikram G. Shakkottai et al.   NEUROLOGIC CLINICS

Selective Positive Modulator of Calcium-Activated Potassium Channels Exerts Beneficial Effects in a Mouse Model of Spinocerebellar Ataxia Type 2

(2012) Adebimpe W. Kasumu et al.   CHEMISTRY & BIOLOGY

Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2

(2012) S. T. Hansen et al.   HUMAN MOLECULAR GENETICS

Cerebellar Ataxia by Enhanced CaV2.1 Currents Is Alleviated by Ca2+-Dependent K+-Channel Activators in Cacna1aS218L Mutant Mice

(2012) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

Aminopyridines Correct Early Dysfunction and Delay Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia Type 1

(2011) R. Hourez et al.   JOURNAL OF NEUROSCIENCE

Mutant PKC  in Spinocerebellar Ataxia Type 14 Disrupts Synapse Elimination and Long-Term Depression in Purkinje Cells In Vivo

(2011) A. N. Shuvaev et al.   JOURNAL OF NEUROSCIENCE

Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3

(2011) V. G. Shakkottai et al.   JOURNAL OF NEUROSCIENCE

Spatiotemporal firing patterns in the cerebellum

(2011) Chris I. De Zeeuw et al.   NATURE REVIEWS NEUROSCIENCE

Dendritic Kv3.3 Potassium Channels in Cerebellar Purkinje Cells Regulate Generation and Spatial Dynamics of Dendritic Ca2+ Spikes

(2010) Edward Zagha et al.   JOURNAL OF NEUROPHYSIOLOGY

KCa Channels as Therapeutic Targets in Episodic Ataxia Type-2

(2010) K. Alvina et al.   JOURNAL OF NEUROSCIENCE

Autosomal dominant cerebellar ataxias: polyglutamine expansions and beyond

(2010) Alexandra Durr   LANCET NEUROLOGY

PKC and the control of localized signal dynamics

(2010) Carine Rosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stereological quantification of the cerebellum in patients with Alzheimer's disease

(2010) Kjeld Andersen et al.   NEUROBIOLOGY OF AGING

Regulation of sodium channel activity by phosphorylation

(2010) Todd Scheuer   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Physiologic Alterations in Ataxia

(2009) Vikram G. Shakkottai et al.   ARCHIVES OF NEUROLOGY

Phosphorylation of ATXN1 at Ser776 in the cerebellum

(2009) Nathan D. Jorgensen et al.   JOURNAL OF NEUROCHEMISTRY

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Protein Kinase C Modulates Inactivation of Kv3.3 Channels

(2008) Rooma Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymological Analysis of Mutant Protein Kinase Cγ Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+Homeostasis

(2008) Naoko Adachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY