Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice

Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability

(2015) J. M. Dell'Orco et al.   JOURNAL OF NEUROSCIENCE

Neuronal calcium signaling: function and dysfunction

(2014) Marisa Brini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Moonwalker Mouse: New Insights into TRPC3 Function, Cerebellar Development, and Ataxia

(2014) Esther B. E. Becker   CEREBELLUM

Mutant  -III Spectrin Causes mGluR1  Mislocalization and Functional Deficits in a Mouse Model of Spinocerebellar Ataxia Type 5

(2014) K. R. Armbrust et al.   JOURNAL OF NEUROSCIENCE

Do mutations in the murine ataxia geneTRPC3cause cerebellar ataxia in humans?

(2014) Brent L. Fogel et al.   MOVEMENT DISORDERS

Neuronal morphometry directly from bitmap images

(2014) Tiago A Ferreira et al.   NATURE METHODS

Cerebellar modules operate at different frequencies

(2014) Haibo Zhou et al.   eLife

Insights From Cerebellar Transcriptomic Analysis Into the Pathogenesis of Ataxia

(2014) Conceição Bettencourt et al.   JAMA Neurology

Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor

(2014) Chanjuan Xu et al.   Frontiers in Pharmacology

Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells

(2013) Ayumu Konno et al.   CEREBELLUM

Functional Cooperation of Metabotropic Adenosine and Glutamate Receptors Regulates Postsynaptic Plasticity in the Cerebellum

(2013) Y. Kamikubo et al.   JOURNAL OF NEUROSCIENCE

Activation of Cerebellar B-type ^|^gamma;-aminobutyric Acid Receptor Modulates Optokinetic Reflex Adaptation

(2013) Yoshihiro Shirai et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1

(2013) Serena Notartomaso et al.   Molecular Brain

Autosomal-Recessive Congenital Cerebellar Ataxia Is Caused by Mutations in Metabotropic Glutamate Receptor 1

(2012) Velina Guergueltcheva et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia

(2012) Sherry-Ann Brown et al.   BMC Systems Biology

Distributed synergistic plasticity and cerebellar learning

(2012) Zhenyu Gao et al.   NATURE REVIEWS NEUROSCIENCE

SCA1—Phosphorylation, a regulator of Ataxin-1 function and pathogenesis

(2012) Harry T. Orr   PROGRESS IN NEUROBIOLOGY

Group 1 Metabotropic Glutamate Receptor Function and Its Regulation of Learning and Memory in the Aging Brain

(2012) Caroline Ménard et al.   Frontiers in Pharmacology

Calcium as a Trigger for Cerebellar Long-Term Synaptic Depression

(2011) Elizabeth A. Finch et al.   CEREBELLUM

Aminopyridines Correct Early Dysfunction and Delay Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia Type 1

(2011) R. Hourez et al.   JOURNAL OF NEUROSCIENCE

Abnormalities in the Climbing Fiber-Purkinje Cell Circuitry Contribute to Neuronal Dysfunction in ATXN1[82Q] Mice

(2011) J. A. Barnes et al.   JOURNAL OF NEUROSCIENCE

Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses instaggerermutant mice

(2011) Kazuhiro Mitsumura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Spatiotemporal firing patterns in the cerebellum

(2011) Chris I. De Zeeuw et al.   NATURE REVIEWS NEUROSCIENCE

Role of Inositol 1,4,5-Trishosphate Receptors in Pathogenesis of Huntington’s Disease and Spinocerebellar Ataxias

(2011) Ilya Bezprozvanny   NEUROCHEMICAL RESEARCH

Post-training cerebellar cortical activity plays an important role for consolidation of memory of cerebellum-dependent motor learning

(2011) Takehito Okamoto et al.   NEUROSCIENCE LETTERS

Exercise and Genetic Rescue of SCA1 via the Transcriptional Repressor Capicua

(2011) J. D. Fryer et al.   SCIENCE

mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons

(2011) J. Hartmann et al.   Cold Spring Harbor Perspectives in Biology

Contributions of T-Type Voltage-Gated Calcium Channels to Postsynaptic Calcium Signaling within Purkinje Neurons

(2010) Philippe Isope et al.   CEREBELLUM

SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells

(2010) Constance Smith-Hicks et al.   NATURE NEUROSCIENCE

Fluorescent pipettes for optically targeted patch-clamp recordings

(2010) Daisuke Ishikawa et al.   NEURAL NETWORKS

Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling

(2010) Stephanie Schorge et al.   TRENDS IN NEUROSCIENCES

Protein translation in synaptic plasticity: mGluR-LTD, Fragile X

(2009) Maggie W Waung et al.   CURRENT OPINION IN NEUROBIOLOGY

Functional crosstalk between GPCRs: with or without oligomerization

(2009) Laurent Prezeau et al.   CURRENT OPINION IN PHARMACOLOGY

Rescue of abnormal phenotypes in δ2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the δ2 glutamate receptor

(2009) Takashi Torashima et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Dual involvement of G-substrate in motor learning revealed by gene deletion

(2009) S. Endo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Phosphatidylinositol-4,5-Bisphosphate Signaling in Cerebellar Purkinje Spines

(2008) Sherry-Ann Brown et al.   BIOPHYSICAL JOURNAL

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 3

(2008) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Chemical calcium indicators

(2008) R. Madelaine Paredes et al.   METHODS

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

(2008) Jana Hartmann et al.   NEURON

Purkinje-cell-preferential transduction by lentiviral vectors with the murine stem cell virus promoter

(2008) Kiyohiko Takayama et al.   NEUROSCIENCE LETTERS

Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives

(2008) F. Ferraguti et al.   PHARMACOLOGICAL REVIEWS

Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination

(2008) M. Kano et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES