Review
Genetics & Heredity
Francesco Manfrevola, Florian Guillou, Silvia Fasano, Riccardo Pierantoni, Rosanna Chianese
Summary: During spermatogenesis, the nuclear architecture undergoes extensive remodeling, with the LINC complex playing a key role in connecting the nucleoskeleton to the cytoskeleton and governing mechanotransduction. This complex is crucial for sperm morphological maturation and may be important in determining male fertility.
Article
Cell Biology
Rebecca M. Mcgillivary, Daniel A. Starr, G. W. Gant Luxton
Summary: This article discusses the regulation of the SUN-KASH interaction, which forms the core of the LINC complex. By regulating the assembly and disassembly of LINC complexes, cells are able to control the interaction of SUN-KASH to participate in various critical cellular processes.
CURRENT OPINION IN CELL BIOLOGY
(2023)
Review
Cell Biology
Bakhita R. M. Meqbel, Matilde Gomes, Amr Omer, Imed E. Gallouzi, Henning F. Horn
Summary: The nuclear envelope plays a crucial role in cellular organization, signaling, and survival, and is particularly important in the process of senescence. Specific proteins of the nuclear envelope, such as Lamin B1 and LINC complex proteins, have been identified as key players in senescence, and have functions beyond their role in forming the nuclear envelope. These proteins are involved in DNA repair, cell signaling, and nuclear shape regulation, all of which are important in senescence.
Article
Plant Sciences
Xinhua Zeng, Hao Li, Keqi Li, Rong Yuan, Shengbo Zhao, Jun Li, Junling Luo, Xiaofei Li, Hong Ma, Gang Wu, Xiaohong Yan
Summary: The research identified that the MS5 gene in Brassica napus is inherited from a basic diploid ancestor and it has functional differences in the plant. This gene belongs to a Brassicaceae-specific new gene family and has gained a novel function crucial for male fertility in B. napus through neofunctionalization.
Review
Cell Biology
Zeinab Jahed, Nya Domkam, Jessica Ornowski, Ghafar Yerima, Mohammad R. K. Mofrad
Summary: Large protein complexes called LINC complexes assemble at the nuclear envelope to transmit mechanical signals between the cytoskeleton and nucleoskeleton. These complexes are formed by the interaction of SUN and KASH domain proteins and can withstand and transfer forces across the nuclear envelope. Recent studies have shed light on the mechanisms of SUN-KASH interactions, their higher-order assembly, and the molecular mechanisms of force transfer across these complexes.
JOURNAL OF CELL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Fotios Dimitriadis, Hendrik Borgmann, Julian P. Struck, Johannes Salem, Timur H. Kuru
Summary: The aim of this review was to evaluate the effect of antioxidant supplementation (AS) on male fertility parameters. Numerous studies have shown a positive impact of AS on assisted reproductive therapy outcomes, semen parameters, and live birth rate. However, there is still a need for further research to determine the optimal combination of antioxidants and the influence of environmental factors.
Article
Multidisciplinary Sciences
Marika K. Kucinska, Juliette Fedry, Carmela Galli, Diego Morone, Andrea Raimondi, Tatiana Solda, Friedrich Forster, Maurizio Molinari
Summary: This study reveals that expansion of the mammalian ER leads to the disassembly of LINC complexes and swelling of ONM. Upon resolution of ER stress, the physiologic distance between ONM and INM is restored through a catabolic pathway called micro-ONM-phagy.
NATURE COMMUNICATIONS
(2023)
Review
Obstetrics & Gynecology
Patra Priyadarshini Priyanka, Suresh Yenugu
Summary: CCDC proteins with coiled-coil domains play crucial roles in various physiological and pathological processes, influencing important biological functions, cancer pathogenesis, and lifetime disease risk. Extensively studied, there is ample opportunity for further exploration of their involvement in different functions in the future.
REPRODUCTIVE SCIENCES
(2021)
Article
Cell Biology
Nanami Ueda, Masashi Maekawa, Tsubasa S. Matsui, Shinji Deguchi, Tomoyo Takata, Jun Katahira, Shigeki Higashiyama, Miki Hieda
Summary: The linker of nucleoskeleton and cytoskeleton (LINC) complex plays a critical role in regulating cellular structure and signaling during cell migration through traction force. SUN1, a component of the LINC complex, is involved in the maturation of focal adhesions and activation of integrin beta 1, which are both dependent on traction force.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
XueXia Liu, ZhiXin Wang, Fujun Liu
Summary: Mice treated with BPA exhibited decreased sperm quality, lower serum testosterone levels, and a sub-fertile phenotype, mainly due to impaired germ cell proliferation. BPA had a concentration-dependent inhibition effect on germ cell proliferation, leading to reduced male fertility.
Article
Endocrinology & Metabolism
Shun Bai, Meihong Hu, Lina Yu, Linjun Chen, Jidong Zhou, Limin Wu, Bo Xu, Xiaohua Jiang, Xindong Zhang, Xianhong Tong, Qiuling Yue
Summary: Background: DNAJB7 is a highly conserved protein involved in various biological processes. However, its function in spermatogenesis and male fertility has been unclear. Methods: Dnajb7-deficient mice were generated using CRISPR/Cas9-mediated genome editing system to investigate the role of DNAJB7 in male reproduction. Results: DNAJB7 is specifically expressed in haploid germ cells. Dnajb7 knockout mice are fertile and show no defects in Sertoli cells, spermatogonia, meiotic and postmeiotic cells, suggesting that DNAJB7 is not essential for spermatogenesis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jingjing Hou, Weiwei Fan, Ruirui Ma, Bing Li, Zhihui Yuan, Wenxuan Huang, Yueying Wu, Quan Hu, Chunjing Lin, Xingqi Zhao, Bao Peng, Limei Zhao, Chunbao Zhang, Lianjun Sun
Summary: This study identified a gene, MS3, associated with male sterility in soybean and found that its mutation affects pollen and pod formation as well as carbohydrate metabolism. Interestingly, the mutant can restore fertility under long-day conditions, which has significant implications for hybrid seed production.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mekonnen Haile-Mariam, J. E. Pryce
Summary: The study quantified variation in male and female fertility, identifying factors affecting non-return rate such as age, season of mating, and inbreeding of cows and bulls. Models were used to calculate male and female fertility, with important findings regarding the heritability of male fertility.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Malvina Hoxha, Arcangelo Barbonetti, Bruno Zappacosta
Summary: The available literature synthesis suggests an association between the arachidonic acid (AA) pathway and male fertility based on in vivo animal studies and human clinical trials. PGE is significantly reduced in the semen of infertile men, indicating the potential of PGE agonists to improve male fertility. Interestingly, ibuprofen can negatively affect male fertility by inducing alterations in sperm function and standard semen parameters. Targeting the AA pathways could be an attractive strategy for the treatment of male fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shuwen Shan, Fangzheng Xu, Marc Hirschfeld, Bertram Brenig
Summary: Sperm plasma membrane lipids play a crucial role in maintaining the function and integrity of mammalian spermatozoa. Different types of lipids are involved in key steps of fertilization in a coordinated manner, with balanced lipid metabolism being essential for physiological cellular processes, especially for sperm motility, capacitation, acrosome reaction, and fusion. Studies suggest that male reproductive function is influenced by the homeostasis of sperm lipids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kefei Yang, Marco Andreas Tylkowski, Daniela Hueber, Constanza Tapia Contreras, Sigrid Hoyer-Fender
JOURNAL OF CELL SCIENCE
(2018)
Article
Ecology
Sigrid Hoyer-Fender
Review
Cell Biology
Constanza Tapia Contreras, Sigrid Hoyer-Fender
Summary: The formation of the sperm tail is essential for the transmission of genetic material during spermatogenesis. It involves the reorganization of the male germ cell, including changes in the nucleus, formation of the acrosomal vesicle, and development of the sperm tail. The connecting piece between the sperm head and tail plays a crucial role in the overall structure of the sperm cell.
Article
Biochemistry & Molecular Biology
Sigrid Hoyer-Fender
Summary: ODF1 is a crucial protein in the accessory fibres of mammalian sperm tail and is also found in the connecting piece. Depletion of ODF1 leads to sperm decapitation, but has no effect on the development of the connecting piece.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Amir Mohammad Rahimi, Mingfang Cai, Sigrid Hoyer-Fender
Summary: In this study, the embryonic mouse fibroblast cell line NIH3T3 was utilized to establish homogeneous cell lines for research on molecular signatures and pathways associated with ciliation.