Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

(2017) Leon A Adams et al.   GUT

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

(2017) Omar A. Mesarwi et al.   PLoS One

SerpinB3 Promotes Pro-fibrogenic Responses in Activated Hepatic Stellate Cells

(2017) Erica Novo et al.   Scientific Reports

Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease

(2016) Sander Lefere et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histidine-rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease

(2016) Matthias Bartneck et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

(2015) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management

(2015) Stuart McPherson et al.   JOURNAL OF HEPATOLOGY

Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease

(2015) Sanjaya Satapathy et al.   SEMINARS IN LIVER DISEASE

SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity

(2015) Cristian Turato et al.   Scientific Reports

Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells

(2015) Stefania Cannito et al.   Oncotarget

M2 Kupffer Cells Promote Hepatocyte Senescence

(2014) Jinghong Wan et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular and molecular mechanisms in liver fibrogenesis

(2014) Erica Novo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice

(2014) Irene Locatelli et al.   HEPATOLOGY

Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions

(2014) Garrick K. Wilson et al.   JOURNAL OF HEPATOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

HCC Development Is Associated to Peripheral Insulin Resistance in a Mouse Model of NASH

(2014) Samuele De Minicis et al.   PLoS One

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH

(2013) Salvatore Sutti et al.   HEPATOLOGY

Hypoxia-inducible factors: Crosstalk between inflammation and metabolism

(2012) Jessica E.S. Shay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nonalcoholic Steatohepatitis and Noncirrhotic Hepatocellular Carcinoma: Fertile Soil

(2012) Dawn Torres et al.   SEMINARS IN LIVER DISEASE

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice

(2011) Daigo Ochiai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice

(2011) Bharath Nath et al.   HEPATOLOGY

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

(2011) Aijuan Qu et al.   HEPATOLOGY

Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

(2011) Bharath Nath et al.   HEPATOLOGY

HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice

(2011) Yasumasa Nishiyama et al.   JOURNAL OF HEPATOLOGY

Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells

(2010) Erica Novo et al.   JOURNAL OF HEPATOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

(2009) Jeon-OK Moon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism

(2009) E. B. Rankin et al.   MOLECULAR AND CELLULAR BIOLOGY

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo

(2008) Sudheer K. Mantena et al.   BIOCHEMICAL JOURNAL

Monitoring SCCA-IgM complexes in serum predicts liver disease progression in patients with chronic hepatitis

(2008) A. Biasiolo et al.   JOURNAL OF VIRAL HEPATITIS