Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science

Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease

(2017) Charlie C. Park et al.   GASTROENTEROLOGY

Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease

(2017) Raj Vuppalanchi et al.   HEPATOLOGY

Diagnostic Performance of MR Elastography and Vibration-controlled Transient Elastography in the Detection of Hepatic Fibrosis in Patients with Severe to Morbid Obesity

(2017) Jun Chen et al.   RADIOLOGY

Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis

(2016) Stuart McPherson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

507 APRI and FIB-4 Index Scores Can Enrich for Subjects With Fibrotic Non-Alcoholic Steatohepatitis (NASH) in Clinical Trials - The CENTAUR Trial Data

(2016) Arun J. Sanyal et al.   GASTROENTEROLOGY

Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography

(2016) Kento Imajo et al.   GASTROENTEROLOGY

Performance of non-invasive models of fibrosis in predicting mild to moderate fibrosis in patients with non-alcoholic fatty liver disease

(2016) Mohammad S. Siddiqui et al.   LIVER INTERNATIONAL

Discrimination of Nonalcoholic Steatohepatitis Using Transient Elastography in Patients with Nonalcoholic Fatty Liver Disease

(2016) Hye Won Lee et al.   PLoS One

Severity of Nonalcoholic Fatty Liver Disease and Progression to Cirrhosis Are Associated With Atherogenic Lipoprotein Profile

(2015) Mohammad S. Siddiqui et al.   Clinical Gastroenterology and Hepatology

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

(2015) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Accuracy of Ultrasound and Noninvasive Markers of Fibrosis to Identify Patients with Cirrhosis

(2015) Jason Martin et al.   DIGESTIVE DISEASES AND SCIENCES

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop

(2015) Arun J. Sanyal et al.   HEPATOLOGY

Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)

(2015) Rohit Loomba et al.   HEPATOLOGY

Expanding consensus in portal hypertension

(2015) Roberto de Franchis   JOURNAL OF HEPATOLOGY

EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis

(2015)   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity

(2015) Kevin J. Fagan et al.   LIVER INTERNATIONAL

Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease

(2014) L. Fedchuk et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: A meta-analysis of diagnostic accuracy

(2014) Ke-Qing Shi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease - the role of transient elastography and plasma cytokeratin-18 fragments

(2013) R. Kwok et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

(2013) Mazen Noureddin et al.   HEPATOLOGY

Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease

(2013) Kenneth Cusi et al.   JOURNAL OF HEPATOLOGY

Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients

(2012) Pierre Bedossa et al.   HEPATOLOGY

Transient elastography: a meta-analysis of diagnostic accuracy in evaluation of portal hypertension in chronic liver disease

(2012) Ke-Qing Shi et al.   LIVER INTERNATIONAL

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality

(2011) Zobair M. Younossi et al.   HEPATOLOGY

Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis

(2011) Ruben Hernaez et al.   HEPATOLOGY

Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease

(2010) Brent A. Neuschwander-Tetri et al.   HEPATOLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

In vivo 3T spectroscopic quantification of liver fat content in nonalcoholic fatty liver disease: Correlation with biochemical method and morphometry

(2010) Ernesto Roldan-Valadez et al.   JOURNAL OF HEPATOLOGY

Non-invasive assessment of hepatic steatosis: Prospective comparison of the accuracy of imaging examinations

(2010) Seung Soo Lee et al.   JOURNAL OF HEPATOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diagnostic Value of a Computerized Hepatorenal Index for Sonographic Quantification of Liver Steatosis

(2009) Muriel Webb et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Decreased survival of subjects with elevated liver function tests during a 28-year follow-up

(2009) Cecilia Söderberg et al.   HEPATOLOGY

Validity of real time ultrasound in the diagnosis of hepatic steatosis: A prospective study

(2009) Srinivasan Dasarathy et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic Fatty Liver Disease: Diagnostic and Fat-Grading Accuracy of Low-Flip-Angle Multiecho Gradient-Recalled-Echo MR Imaging at 1.5 T

(2009) Takeshi Yokoo et al.   RADIOLOGY

Mechanisms of extrahepatic vasodilation in portal hypertension

(2008) M Hennenberg et al.   GUT

Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network

(2008) Elizabeth M. Brunt et al.   HEPATOLOGY

Liver biopsy

(2008) Don C. Rockey et al.   HEPATOLOGY