Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization

UsingDrosophilato discover mechanisms underlying type 2 diabetes

(2016) Ronald W. Alfa et al.   Disease Models & Mechanisms

Browning of White Fat: Novel Insight Into Factors, Mechanisms, and Therapeutics

(2016) Nevena Jeremic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling

(2016) Joo Yeun Lee et al.   PLoS Genetics

A genetically encoded biosensor for visualising hypoxia responsesin vivo

(2016) Tvisha Misra et al.   Biology Open

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

The extracellular matrix and insulin resistance

(2015) Ashley S. Williams et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3

(2015) Jung Kim et al.   Nature Communications

Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

(2015) Joanna P Rys et al.   eLife

Obesity, insulin resistance and comorbidities ? Mechanisms of association

(2014) Ana Valeria B. Castro et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications

(2014) A. Dawydow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Talin Autoinhibition Is Required for Morphogenesis

(2013) Stephanie J. Ellis et al.   CURRENT BIOLOGY

The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting

(2013) Brittany L. Jacobs et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Development of diet-induced insulin resistance in adult Drosophila melanogaster

(2012) Siti Nur Sarah Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

High Sugar-Induced Insulin Resistance in Drosophila Relies on the Lipocalin Neural Lazarillo

(2012) Matthieu Y. Pasco et al.   PLoS One

Shaping Cells and Organs in Drosophila by Opposing Roles of Fat Body-Secreted Collagen IV and Perlecan

(2011) José Carlos Pastor-Pareja et al.   DEVELOPMENTAL CELL

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

(2011) L. Palanker Musselman et al.   Disease Models & Mechanisms

PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

(2010) Kathrin S. Zeller et al.   CELLULAR SIGNALLING

Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology

(2010) James Beattie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States

(2009) Maija Slaidina et al.   DEVELOPMENTAL CELL

A Fat Body-Derived IGF-like Peptide Regulates Postfeeding Growth in Drosophila

(2009) Naoki Okamoto et al.   DEVELOPMENTAL CELL

Insulin Resistance in Striated Muscle-specific Integrin Receptor β1-deficient Mice

(2008) Haihong Zong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY