Article
Genetics & Heredity
Yuanxue Yang, Yun Zhang, Aiyu Wang, Ailing Duan, Chao Xue, Kaiyun Wang, Ming Zhao, Jianhua Zhang
Summary: This study investigated the resistance of Spodoptera frugiperda to insecticides and the regulatory roles of miRNAs. RNA-Seq analysis revealed that differentially expressed miRNAs play an important role in the insecticide resistance of S. frugiperda. Overexpression of specific miRNAs significantly increased the mortality of S. frugiperda to insecticides.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
Article
Genetics & Heredity
Oyvind P. Haugena, Cuong M. Khuu, Hanne M. Weidemann, Tor Paaske Utheim, Linda Hildegard Bergersen
Summary: In pancreatic ductal adenocarcinoma (PDAC), the lactate receptor HCAR1 is highly expressed and regulated by miRNA miR-431-5p. Overexpression of miR-431-5p inhibits cell proliferation, induces cell cycle progression changes and apoptosis in PDAC cells. Transcriptomic analysis reveals that numerous differentially expressed genes (DEGs), especially ATP6V0E1, are involved in cancer-related processes and signaling pathways. Knockdown of ATP6V0E1, instead of HCAR1, mimics the effects of miR-431-5p overexpression on cell viability in PDAC cells.
Article
Biochemistry & Molecular Biology
Chiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barilla, Francesco Romeo, Giuseppe Novelli, Francesca Amati
Summary: Coronary heart disease (CHD) is a leading cause of disability and death globally, and its early diagnosis is challenging. A pilot study on peripheral blood cells revealed potential biomarkers, including hsa-miR-200c-3p, for the diagnosis and clinical progression of CHD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Omayma O. Abdelaleem, Shereen Rashad Mohammed, Hassan S. El Sayed, Sherin Khamis Hussein, Doaa Y. Ali, Mostafa Y. Abdelwahed, Sylvana N. Gaber, Nada F. Hemeda, Rehab G. Abd El-Hmid
Summary: This study found that serum levels of miR-34a-5p and miR-199a-3p were significantly reduced in neonates with sepsis, and they were associated with the severity of sepsis.
Article
Genetics & Heredity
Linxiang Feng, Zian Feng, Jie Hu, Jiahui Gao, Ang Li, Xiaodong He, Liu Liu, Zuojun Shen
Summary: In this study, high-throughput sequencing of miRNAs in plasma exosomes from lung adenocarcinoma patients and healthy individuals was performed. The results identified hsa-miR-4454 and hsa-miR-619-5p as potential biomarkers for the early diagnosis of lung adenocarcinoma.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A. Shaheen, Areej Rushdi, Reem M. Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I. Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert
Summary: Early HCC diagnosis is challenging, especially for AFP-negative cases. miRNA profiles may serve as potential molecular markers for HCC. This study aimed to evaluate the expression levels of four miRNAs (hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p) as biomarkers for HCC in CHCV patients with liver cirrhosis, particularly AFP-negative HCC cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Liping Zou, Qiwen Feng, Wei Xia, Changhong Zhu
Summary: This study aimed to identify common targets of miR-223-3p, miR-122-5p, and miR-93-5p in PCOS and assess their transcript levels in PCOS rat ovaries. Transcriptome profiles of granulosa cells from PCOS patients were analyzed to identify DEGs, followed by miRNA target prediction and functional analysis. The study identified several potential genes, including JMJD1C, PLCG2, SMAD3, FOSL2, TGFB1, TRIB1, GAS7, TRIM25, NFYA, and CALCRL, which may play a role in the development of PCOS. These findings contribute to the identification of potential biomarkers for the prevention and treatment of PCOS in the future.
FRONTIERS IN GENETICS
(2023)
Article
Clinical Neurology
Michela Ferraldeschi, Silvia Romano, Simona Giglio, Carmela Romano, Emanuele Morena, Rosella Mechelli, Viviana Annibali, Martina Ubaldi, Maria Chiara Buscarinu, Renato Umeton, Gabriele Sani, Andrea Vecchione, Marco Salvetti, Giovanni Ristori
Summary: The study identified specific plasma miRNA markers in HD patients, suggesting their potential role in characterizing the disease and determining therapeutic targets. Molecular and bioinformatic analyses revealed an interaction between these miRNAs and the HTT protein, indicating their biological plausibility in HD pathophysiology.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Patricia de la Cruz-Ojeda, Tobias Schmid, Loreto Boix, Manuela Moreno, Victor Sapena, Juan M. Praena-Fernandez, Francisco J. Castell, Juan Manuel Falcon-Perez, Maria Reig, Bernhard Bruene, Miguel A. Gomez-Bravo, Alvaro Giraldez, Jordi Bruix, Maria T. Ferrer, Jordi Muntane
Summary: The study reveals that Sorafenib regulates a specific miRNA signature, where miR-200c-3p, miR-222-5p, and miR-512-3p have prognostic value and contribute to treatment response.
Article
Oncology
Aliza Mohd Yacob, Nor Asiah Muhamad, Kian Meng Chang, Hamidah Akmal Hisham, Yuslina Mat Yusoff, Latifah Ibrahim
Summary: The study used Next Generation Sequencing (NGS) to identify microRNAs (miRNAs) at the molecular response in CML adult patients receiving TKIs treatment. Specific miRNAs showed significant expression in the treatment response of CML patients and may serve as new therapeutic biomarkers.
Article
Oncology
Wenyan Liao, Jun He, Cyrollah Disoma, Yi Hu, Junhua Li, Guodong Chen, Ying Sheng, Xinyu Cai, Chuanfu Li, Kai Cheng, Chunfen Yang, Yongxi Qin, Dong Han, Wu Wen, Chengming Ding, Mujun Li
Summary: This study demonstrated that hsa_circ_0107593 has low expression in cervical cancer tissues and cell lines, negatively correlated with tumor characteristics, and inhibits cell proliferation, migration, and invasion. It may serve as a diagnostic biomarker due to its tumor-suppressing activity by sponging hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p in cervical cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Fengping Yan, Yuanyuan Chen, Xing Ye, Fu Zhang, Shiquan Wang, Le Zhang, Xiaoting Luo
Summary: Sudden cardiac death (SCD) is a major health threat and diagnostic challenges persist, especially in cases without positive autopsy findings. In this study, specific cardio-miRNAs were investigated as potential biomarkers for SCD diagnosis. The results showed that four cardio-miRNAs were significantly up-regulated in SCD samples, suggesting their potential as independent diagnostic biomarkers, with a combination of two miRNAs aiding in discriminating detailed causes of SCD.
DIAGNOSTIC PATHOLOGY
(2021)
Article
Health Care Sciences & Services
Paola Fuso, Mariantonietta Di Salvatore, Concetta Santonocito, Donatella Guarino, Chiara Autilio, Antonino Mule, Damiano Arciuolo, Antonina Rinninella, Flavio Mignone, Matteo Ramundo, Brunella Di Stefano, Armando Orlandi, Ettore Capoluongo, Nicola Nicolotti, Gianluca Franceschini, Alejandro Martin Sanchez, Giampaolo Tortora, Giovanni Scambia, Carlo Barone, Alessandra Cassano
Summary: The up-regulation of miRNAs let-7a-5p, mirR-100-5p, miR-101-3p, and miR-199a-3p is associated with better event-free survival and overall survival in breast cancer patients, regardless of breast cancer subtypes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Elisa De Tomi, Rachele Campagnari, Elisa Orlandi, Alessia Cardile, Valentina Zanre, Marta Menegazzi, Macarena Gomez-Lira, Giovanni Gotte
Summary: ONC exhibits cytostatic and cytotoxic activities against melanoma by upregulating onco-suppressor microRNAs such as miR-20a-3p, miR-29a-3p, and miR-34a-5p. It also inhibits the expression of proteins involved in cell survival pathways and metastasis. These findings suggest that the anti-tumor effects of ONC in melanoma cells may be mediated by the regulation of miRNAs expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lina Quan, Xue Chen, Aichun Liu, Yan Zhang, Xiuchen Guo, Shujie Yan, Yue Liu
Article
Biochemistry & Molecular Biology
Xiuwen Lan, Jun Xing, Hongyu Gao, Sen Li, Lina Quan, Yang Jiang, Shaohua Ding, Yingwei Xue
BIOLOGICAL TRACE ELEMENT RESEARCH
(2017)
Article
Oncology
Wen Xu, Xiaoxia Li, Lina Quan, Jiying Yao, Guannan Mu, Jingjie Guo, Yitong Wang
LEUKEMIA & LYMPHOMA
(2018)
Article
Biotechnology & Applied Microbiology
Xiuwen Lan, Sen Li, Hongyu Gao, Abiyasi Nanding, Lina Quan, Chunyan Yang, Shaohua Ding, Yingwei Xue
ONCOTARGETS AND THERAPY
(2017)
Article
Oncology
Juan Liu, Lina Quan, Chunhui Zhang, Aichun Liu, Dongxia Tong, Jinghua Wang
Article
Hematology
Lina Quan, Xiuwen Lan, Yuanyuan Meng, Xiuchen Guo, Yiwei Guo, Lina Zhao, Xue Chen, Aichun Liu
EXPERIMENTAL HEMATOLOGY
(2018)
Article
Pathology
Chui-Ming Jia, Yu-Yang Tian, Li-Na Quan, Li Jiang, Ai-Chun Liu
PATHOLOGY RESEARCH AND PRACTICE
(2018)
Article
Oncology
Yuguang Yang, Hongfeng Zhou, Wenming Liu, Jin Wu, Xiaolong Yue, Jincai Wang, Lina Quan, Hang Liu, Li Guo, Zhipeng Wang, Xin Lian, Qingyuan Zhang
Article
Oncology
Shujie Yan, Chuiming Jia, Lina Quan, Lina Zhao, Yuyang Tian, Aichun Liu
MOLECULAR MEDICINE REPORTS
(2019)
Article
Biochemical Research Methods
Yao Chen, Lina Quan, Chuiming Jia, Yiwei Guo, Xinya Wang, Yu Zhang, Yan Jin, Aichun Liu
Summary: This study utilized a quantitative proteomics approach to investigate the mechanisms of bortezomib-resistant recurrent multiple myeloma (RRMM), identifying differentially expressed proteins that may be involved in regulating various biological processes in RRMM. The top candidate for a promising therapeutic target was identified as SERPINB9.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Medicine, Research & Experimental
Lina Quan, Chuiming Jia, Yiwei Guo, Yao Chen, Xinya Wang, Qiuting Xu, Yu Zhang
Summary: This study investigates the methylation pattern of multiple myeloma and its effect on the expression of HNRNPA2B1 and downstream targets. The findings suggest that HNRNPA2B1 increases cell proliferation and deregulates cell apoptosis in multiple myeloma through TLR4 signaling.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.