Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking

PTEN Level in Tumor Suppression: How Much Is Too Little?

(2011) A. Carracedo et al.   CANCER RESEARCH

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

(2011) Xuxiao Zhang et al.   MOLECULAR CELL

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions

(2011) Carlotta Costa et al.   TheScientificWorldJOURNAL

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

(2011) Lydia W.T. Cheung et al.   Cancer Discovery

The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

(2010) C. M. Taniguchi et al.   CANCER RESEARCH

p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN

(2010) Deborah H. Anderson   CELL CYCLE

Rab protein evolution and the history of the eukaryotic endomembrane system

(2010) Andrew Brighouse et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking

(2010) M. Dean Chamberlain et al.   CELLULAR SIGNALLING

Actin dynamics and endocytosis in yeast and mammals

(2010) Brian J Galletta et al.   CURRENT OPINION IN BIOTECHNOLOGY

Rab GEFs and GAPs

(2010) Francis Barr et al.   CURRENT OPINION IN CELL BIOLOGY

PI3KC2 , a class II PI3K, is required for dynamin-independent internalization pathways

(2010) C. Krag et al.   JOURNAL OF CELL SCIENCE

Haplo-insufficiency: a driving force in cancer

(2010) Alice H Berger et al.   JOURNAL OF PATHOLOGY

Integrin-mediated function of Rab GTPases in cancer progression

(2010) Dhatchayini Subramani et al.   Molecular Cancer

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

A biochemical mechanism for the oncogenic potential of the p110  catalytic subunit of phosphoinositide 3-kinase

(2010) H. A. Dbouk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-derived mutations in the regulatory subunit p85  of phosphoinositide 3-kinase function through the catalytic subunit p110 

(2010) M. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

(2010) R. B. Chagpar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab GTPases implicated in inherited and acquired disorders

(2010) Shreya Mitra et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cdc42 and Vesicle Trafficking in Polarized Cells

(2010) Kathryn P. Harris et al.   TRAFFIC

Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases

(2009) Jasmine V. Abella et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Structural studies of the phosphatidylinositol 3-kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding

(2009) Renu Batra-Safferling et al.   BIOLOGICAL CHEMISTRY

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

(2009) Bijay S. Jaiswal et al.   CANCER CELL

A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway

(2009) Christina Ehrhardt et al.   CELLULAR MICROBIOLOGY

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The PKB/AKT Pathway in Cancer

(2009) Amancio Carnero   CURRENT PHARMACEUTICAL DESIGN

p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex

(2009) R. Rabinovsky et al.   MOLECULAR AND CELLULAR BIOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Defining the boundaries: Rab GEFs and GAPs

(2009) R. M. Nottingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A frequent kinase domain mutation that changes the interaction between PI3K  and the membrane

(2009) D. Mandelker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of phosphoinositide 3-kinase expression in health and disease

(2009) Klaartje Kok et al.   TRENDS IN BIOCHEMICAL SCIENCES

Twice upon a time: PI3K's secret double life exposed

(2009) Emilio Hirsch et al.   TRENDS IN BIOCHEMICAL SCIENCES

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase

(2008) Nobuo Tsuboi et al.   BIOCHEMICAL JOURNAL

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

Caspase 8 Promotes Peripheral Localization and Activation of Rab5

(2008) Vicente A. Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupted RabGAP Function of the p85 Subunit of Phosphatidylinositol 3-Kinase Results in Cell Transformation

(2008) M. Dean Chamberlain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear affairs of PTEN

(2008) S. M. Planchon et al.   JOURNAL OF CELL SCIENCE

SNX9 - a prelude to vesicle release

(2008) R. Lundmark et al.   JOURNAL OF CELL SCIENCE

In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation

(2008) Jason G. Weinger et al.   JOURNAL OF NEUROCHEMISTRY

Ca2+-regulated Pool of Phosphatidylinositol-3-phosphate Produced by Phosphatidylinositol 3-Kinase C2α on Neurosecretory Vesicles

(2008) Peter J. Wen et al.   MOLECULAR BIOLOGY OF THE CELL

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE

Class I PI3K in oncogenic cellular transformation

(2008) L Zhao et al.   ONCOGENE

The Pace of Prostatic Intraepithelial Neoplasia Development Is Determined by the Timing of Pten Tumor Suppressor Gene Excision

(2008) H. Artee Luchman et al.   PLoS One

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

(2008) M. Rahdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma

(2008) C. K. Ratnacaram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling