Cellular target engagement: a new paradigm in drug discovery

Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay

(2018) Joseph Shaw et al.   Scientific Reports

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

(2016) Daniel Martinez Molina et al.   Annual Review of Pharmacology and Toxicology

CETSA: a target engagement assay with potential to transform drug discovery

(2015) Annika Jenmalm Jensen et al.   Future Medicinal Chemistry

Discovery of Innovative Therapeutics: Today’s Realities and Tomorrow’s Vision. 2. Pharma’s Challenges and Their Commitment to Innovation

(2014) Magid Abou-Gharbia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replicated, replicable and relevant–target engagement and pharmacological experimentation in the 21st century

(2013) Terry Kenakin et al.   BIOCHEMICAL PHARMACOLOGY

Asymmetry in pay-off predicts how familiar individuals respond to one another

(2013) H. M. V. Granroth-Wilding et al.   Biology Letters

Determining target engagement in living systems

(2013) Gabriel M Simon et al.   Nature Chemical Biology

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

(2012) Swen Hoelder et al.   Molecular Oncology

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

(2011) Paul G. Wyatt et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Getting pharmaceutical R&D back on target

(2011) Mark E Bunnage   Nature Chemical Biology

The influence of the 'organizational factor' on compound quality in drug discovery

(2011) Paul D. Leeson et al.   NATURE REVIEWS DRUG DISCOVERY

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology